PLRKT_MOUSE
ID PLRKT_MOUSE Reviewed; 147 AA.
AC Q9D3P8; Q3TCJ3;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Plasminogen receptor (KT);
DE Short=Plg-R(KT);
GN Name=Plgrkt;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Amnion, and Intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH PLAT, AND
RP MUTAGENESIS OF LYS-147.
RX PubMed=19897580; DOI=10.1182/blood-2008-11-188938;
RA Andronicos N.M., Chen E.I., Baik N., Bai H., Parmer C.M., Kiosses W.B.,
RA Kamps M.P., Yates J.R. III, Parmer R.J., Miles L.A.;
RT "Proteomics-based discovery of a novel, structurally unique, and
RT developmentally regulated plasminogen receptor, Plg-RKT, a major regulator
RT of cell surface plasminogen activation.";
RL Blood 115:1319-1330(2010).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP FUNCTION IN INFLAMMATORY RESPONSE.
RX PubMed=21940822; DOI=10.1182/blood-2011-03-344242;
RA Lighvani S., Baik N., Diggs J.E., Khaldoyanidi S., Parmer R.J., Miles L.A.;
RT "Regulation of macrophage migration by a novel plasminogen receptor Plg-R
RT KT.";
RL Blood 118:5622-5630(2011).
RN [6]
RP FUNCTION IN NEUROENDOCRINE PROHORMONE PROCESSING, TISSUE SPECIFICITY, AND
RP SUBCELLULAR LOCATION.
RX PubMed=21795689; DOI=10.1074/jbc.m111.218693;
RA Bai H., Baik N., Kiosses W.B., Krajewski S., Miles L.A., Parmer R.J.;
RT "The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)),
RT regulates catecholamine release.";
RL J. Biol. Chem. 286:33125-33133(2011).
CC -!- FUNCTION: Receptor for plasminogen. Regulates urokinase plasminogen
CC activator-dependent and stimulates tissue-type plasminogen activator-
CC dependent cell surface plasminogen activation. Proposed to be part of a
CC local catecholaminergic cell plasminogen activation system that
CC regulates neuroendocrine prohormone processing. Involved in regulation
CC of inflammatory response; regulates monocyte chemotactic migration and
CC matrix metalloproteinase activation, such as of MMP2 and MMP9.
CC {ECO:0000269|PubMed:19897580, ECO:0000269|PubMed:21795689,
CC ECO:0000269|PubMed:21940822}.
CC -!- SUBUNIT: Interacts with PLAT. Interacts with PLAUR (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19897580,
CC ECO:0000269|PubMed:21795689}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:19897580, ECO:0000269|PubMed:21795689}.
CC Note=Colocalizes on the cell surface with urokinase plasminogen
CC activator surface receptor/Plaur.
CC -!- TISSUE SPECIFICITY: Expressed in monocytes; detected in differentiated
CC monocytes but not in progenitor cells. Expressed in adrenal medulla and
CC hippocampus. {ECO:0000269|PubMed:21795689}.
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DR EMBL; AK017215; BAB30638.1; -; mRNA.
DR EMBL; AK168454; BAE40355.1; -; mRNA.
DR EMBL; AK170700; BAE41963.1; -; mRNA.
DR EMBL; BC024953; AAH24953.1; -; mRNA.
DR CCDS; CCDS29734.1; -.
DR RefSeq; NP_080638.1; NM_026362.2.
DR RefSeq; XP_011245627.1; XM_011247325.2.
DR RefSeq; XP_011245628.1; XM_011247326.2.
DR RefSeq; XP_017173772.1; XM_017318283.1.
DR RefSeq; XP_017173773.1; XM_017318284.1.
DR RefSeq; XP_017173774.1; XM_017318285.1.
DR RefSeq; XP_017173775.1; XM_017318286.1.
DR RefSeq; XP_017173776.1; XM_017318287.1.
DR AlphaFoldDB; Q9D3P8; -.
DR BioGRID; 212423; 1.
DR IntAct; Q9D3P8; 4.
DR STRING; 10090.ENSMUSP00000120466; -.
DR iPTMnet; Q9D3P8; -.
DR PhosphoSitePlus; Q9D3P8; -.
DR EPD; Q9D3P8; -.
DR MaxQB; Q9D3P8; -.
DR PaxDb; Q9D3P8; -.
DR PeptideAtlas; Q9D3P8; -.
DR PRIDE; Q9D3P8; -.
DR ProteomicsDB; 289454; -.
DR Antibodypedia; 2322; 115 antibodies from 23 providers.
DR DNASU; 67759; -.
DR Ensembl; ENSMUST00000016639; ENSMUSP00000016639; ENSMUSG00000016495.
DR Ensembl; ENSMUST00000143467; ENSMUSP00000120466; ENSMUSG00000016495.
DR GeneID; 67759; -.
DR KEGG; mmu:67759; -.
DR UCSC; uc008hdf.1; mouse.
DR CTD; 55848; -.
DR MGI; MGI:1915009; Plgrkt.
DR VEuPathDB; HostDB:ENSMUSG00000016495; -.
DR eggNOG; KOG4544; Eukaryota.
DR GeneTree; ENSGT00390000000375; -.
DR HOGENOM; CLU_115107_1_0_1; -.
DR InParanoid; Q9D3P8; -.
DR OMA; EANMIME; -.
DR OrthoDB; 1495739at2759; -.
DR PhylomeDB; Q9D3P8; -.
DR TreeFam; TF314698; -.
DR BioGRID-ORCS; 67759; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Plgrkt; mouse.
DR PRO; PR:Q9D3P8; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9D3P8; protein.
DR Bgee; ENSMUSG00000016495; Expressed in thymus and 263 other tissues.
DR ExpressionAtlas; Q9D3P8; baseline and differential.
DR Genevisible; Q9D3P8; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0010756; P:positive regulation of plasminogen activation; IDA:MGI.
DR InterPro; IPR019319; Plg-R(KT).
DR PANTHER; PTHR13411; PTHR13411; 1.
DR Pfam; PF10166; DUF2368; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Chemotaxis; Inflammatory response; Membrane;
KW Plasminogen activation; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..147
FT /note="Plasminogen receptor (KT)"
FT /id="PRO_0000089696"
FT TOPO_DOM 1..52
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..147
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT MUTAGEN 147
FT /note="K->A: Disrupts binding to plasminogen."
FT /evidence="ECO:0000269|PubMed:19897580"
SQ SEQUENCE 147 AA; 17261 MW; 4DBF5F65C6F73C63 CRC64;
MGFIFSKSMN ENMKNQQEFM VTHARLQLER HLTMQNEMRE RQMAMQIAWS REFLKYFGTF
FGIATISLAT GALKRKKPAF LVPIVPLSFI FTYQYDLGYG TLLQRMKSEA EDILETEKTK
LELPKGLITF ESLEKARREQ SKLFSDK
