PLRKT_RAT
ID PLRKT_RAT Reviewed; 147 AA.
AC D4ACN8;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Plasminogen receptor (KT);
DE Short=Plg-R(KT);
GN Name=Plgrkt;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION IN NEUROENDOCRINE PROHORMONE PROCESSING, TISSUE SPECIFICITY,
RP SUBCELLULAR LOCATION, AND INTERACTION WITH PLAUR.
RX PubMed=21795689; DOI=10.1074/jbc.m111.218693;
RA Bai H., Baik N., Kiosses W.B., Krajewski S., Miles L.A., Parmer R.J.;
RT "The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)),
RT regulates catecholamine release.";
RL J. Biol. Chem. 286:33125-33133(2011).
CC -!- FUNCTION: Receptor for plasminogen. Regulates urokinase plasminogen
CC activator-dependent and stimulates tissue-type plasminogen activator-
CC dependent cell surface plasminogen activation. Proposed to be part of a
CC local catecholaminergic cell plasminogen activation system that
CC regulates neuroendocrine prohormone processing. Involved in regulation
CC of inflammatory response; regulates monocyte chemotactic migration and
CC matrix metalloproteinase activation, such as of MMP2 and MMP9 (By
CC similarity). {ECO:0000250, ECO:0000269|PubMed:21795689}.
CC -!- SUBUNIT: Interacts with PLAT (By similarity). Interacts with PLAUR.
CC {ECO:0000250, ECO:0000269|PubMed:21795689}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21795689};
CC Multi-pass membrane protein {ECO:0000269|PubMed:21795689}.
CC Note=Colocalizes on the cell surface with urokinase plasminogen
CC activator surface receptor/PLAUR. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in adrenal medulla (pheochromocytoma).
CC {ECO:0000269|PubMed:21795689}.
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DR EMBL; CH473953; EDM13090.1; -; Genomic_DNA.
DR EMBL; CH473953; EDM13091.1; -; Genomic_DNA.
DR EMBL; CH473953; EDM13092.1; -; Genomic_DNA.
DR RefSeq; NP_001099817.1; NM_001106347.1.
DR RefSeq; XP_006231265.1; XM_006231203.3.
DR RefSeq; XP_006231267.1; XM_006231205.2.
DR AlphaFoldDB; D4ACN8; -.
DR IntAct; D4ACN8; 1.
DR STRING; 10116.ENSRNOP00000021545; -.
DR PaxDb; D4ACN8; -.
DR PeptideAtlas; D4ACN8; -.
DR PRIDE; D4ACN8; -.
DR Ensembl; ENSRNOT00000021544; ENSRNOP00000021545; ENSRNOG00000015932.
DR GeneID; 293888; -.
DR KEGG; rno:293888; -.
DR UCSC; RGD:1306839; rat.
DR CTD; 55848; -.
DR RGD; 1306839; Plgrkt.
DR eggNOG; KOG4544; Eukaryota.
DR GeneTree; ENSGT00390000000375; -.
DR HOGENOM; CLU_115107_1_0_1; -.
DR InParanoid; D4ACN8; -.
DR OMA; EANMIME; -.
DR OrthoDB; 1495739at2759; -.
DR PhylomeDB; D4ACN8; -.
DR TreeFam; TF314698; -.
DR PRO; PR:D4ACN8; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Proteomes; UP000234681; Chromosome 1.
DR Bgee; ENSRNOG00000015932; Expressed in duodenum and 19 other tissues.
DR Genevisible; D4ACN8; RN.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:RGD.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0010756; P:positive regulation of plasminogen activation; ISO:RGD.
DR InterPro; IPR019319; Plg-R(KT).
DR PANTHER; PTHR13411; PTHR13411; 1.
DR Pfam; PF10166; DUF2368; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Chemotaxis; Inflammatory response; Membrane;
KW Plasminogen activation; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..147
FT /note="Plasminogen receptor (KT)"
FT /id="PRO_0000416055"
FT TOPO_DOM 1..52
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..147
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 147 AA; 17312 MW; 4BB77895ECB7282A CRC64;
MGFIFSKSMN ENMKNQQEFM VMHARLQLER QLIMQNEMRE RQMAMQIAWS REFLKYFGTF
FGIATISLAA GAIKRKKPAF LIPIVPLSFI FTYQYDLGYG TLLQRMKSEA EDILETEKTK
LELPKGLITF ESLEKARREQ SKFFSDK
