ID   PLRP2_BOVIN             Reviewed;         267 AA.
AC   P12401;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Placental prolactin-related protein 2;
DE            Short=PRC-II;
DE   AltName: Full=bPRCII;
DE   Flags: Precursor;
GN   Name=PRP2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RX   PubMed=2765528; DOI=10.1021/bi00438a036;
RA   Kessler M.A., Milosavljevic M., Zieler C.G., Schuler L.A.;
RT   "A subfamily of bovine prolactin-related transcripts distinct from
RT   placental lactogen in the fetal placenta.";
RL   Biochemistry 28:5154-5161(1989).
CC   -!- FUNCTION: Placental prolactin-related proteins may play a specific role
CC       during gestation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; M27239; AAA30728.1; -; mRNA.
DR   PIR; A34078; A34078.
DR   AlphaFoldDB; P12401; -.
DR   SMR; P12401; -.
DR   InParanoid; P12401; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0009893; P:positive regulation of metabolic process; IEA:UniProt.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..?
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..267
FT                   /note="Placental prolactin-related protein 2"
FT                   /id="PRO_0000032950"
FT   CARBOHYD        99
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000250|UniProtKB:P05402"
FT   CARBOHYD        121
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000250|UniProtKB:P05402"
FT   DISULFID        126..244
FT                   /evidence="ECO:0000250"
FT   DISULFID        261..267
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   267 AA;  30322 MW;  FA02B405E2C4E8B8 CRC64;
     MVETRLGWEA GGGLGAPGGP GGKLGGLGLA VGGTHSWSGL LKRVDRREAR AQPRLLVLGC
     LLCQGISCPS CGPDMFVSLQ KSLIDVFINA ASLSHDFHNL STIMFNEFDE KYAQGKLYYI
     NATKSCHTNS FHTPEERDKA QQMNNEDLSK WTLVLLYSWN NPLYYLLLEL RNMKNLSEAV
     ISSAMEIENM SEKLQAFIES QFRKIIVPVL KMIHEVSNTW SRFSSMTFSD EDRSISEYYN
     LFYCLRRDSR KVDMYIKILT CRTRKTC