ID   PLRP3_BOVIN             Reviewed;         213 AA.
AC   P12402;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Placental prolactin-related protein 3;
DE   AltName: Full=PRC-III;
DE   AltName: Full=bPRCIII;
DE   Flags: Precursor;
GN   Name=PRP3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RX   PubMed=2765528; DOI=10.1021/bi00438a036;
RA   Kessler M.A., Milosavljevic M., Zieler C.G., Schuler L.A.;
RT   "A subfamily of bovine prolactin-related transcripts distinct from
RT   placental lactogen in the fetal placenta.";
RL   Biochemistry 28:5154-5161(1989).
CC   -!- FUNCTION: Placental prolactin-related proteins may play a specific role
CC       during gestation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M27240; AAA30729.1; -; mRNA.
DR   PIR; B34078; B34078.
DR   RefSeq; NP_776585.1; NM_174160.2.
DR   AlphaFoldDB; P12402; -.
DR   SMR; P12402; -.
DR   STRING; 9913.ENSBTAP00000017916; -.
DR   PaxDb; P12402; -.
DR   GeneID; 281430; -.
DR   KEGG; bta:281430; -.
DR   CTD; 40172; -.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   InParanoid; P12402; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR   GO; GO:0009893; P:positive regulation of metabolic process; IEA:UniProt.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..13
FT                   /evidence="ECO:0000255"
FT   CHAIN           14..213
FT                   /note="Placental prolactin-related protein 3"
FT                   /id="PRO_0000032951"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000250|UniProtKB:P05402"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000250|UniProtKB:P05402"
FT   DISULFID        72..190
FT                   /evidence="ECO:0000250"
FT   DISULFID        207..213
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   213 AA;  25016 MW;  21805D709296296A CRC64;
     MVMSNLLLCQ VNSCPSCCPD VFDIPLESLT HLFLNASRLS HDIVNHTTIM FHEFDEKYAQ
     NQPYTINATK SCHTNSLHTP QEREKALRMN NEDLSKWILM LLYSWHRPLY LLVKDLQSMK
     EVSDTILSSA KENMRKIEEL QAFIERQFSQ VIYPVIRTIF KARIYWSGLA SLVSNDEDVR
     HSAFYKLFMC LYRDSRKLDM YTEILACRIT NTC