ID   PLS1_PITOR              Reviewed;          20 AA.
AC   P84569;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Phylloseptin-O1 {ECO:0000303|PubMed:18644413};
DE            Short=PLS-O1 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=Phylloseptin-4 {ECO:0000303|PubMed:15752569};
DE            Short=PS-4 {ECO:0000303|PubMed:15752569};
GN   Name=psn4; Synonyms=psn-4;
OS   Pithecopus oreades (Orange-legged leaf frog) (Phyllomedusa oreades).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=239355;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT GLY-20.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:15752569};
RX   PubMed=15752569; DOI=10.1016/j.peptides.2004.11.002;
RA   Leite J.R.S.A., Silva L.P., Rodrigues M.I.S., Prates M.V., Brand G.D.,
RA   Lacava B.M., Azevedo R.B., Bocca A.L., Albuquerque S., Bloch C. Jr.;
RT   "Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides
RT   from the Phyllomedusa genus.";
RL   Peptides 26:565-573(2005).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Has antiprotozoal activity against T.cruzi.
CC       {ECO:0000269|PubMed:15752569}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15752569}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:15752569}.
CC   -!- MASS SPECTROMETRY: Mass=2112.18; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:15752569};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Phylloseptin subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=00759";
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DR   AlphaFoldDB; P84569; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..20
FT                   /note="Phylloseptin-O1"
FT                   /id="PRO_0000043825"
FT   MOD_RES         20
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:15752569"
SQ   SEQUENCE   20 AA;  2113 MW;  C648D1C5C8B91CFF CRC64;
     FLSLIPHAIN AVSTLVHHSG