ID   PLS2_PITOR              Reviewed;          19 AA.
AC   P84570;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Phylloseptin-O2 {ECO:0000303|PubMed:18644413};
DE            Short=PLS-O2 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=Phylloseptin-5 {ECO:0000303|PubMed:15752569};
DE            Short=PS-5 {ECO:0000303|PubMed:15752569};
GN   Name=psn5; Synonyms=psn-5;
OS   Pithecopus oreades (Orange-legged leaf frog) (Phyllomedusa oreades).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=239355;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT SER-19.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:15752569};
RX   PubMed=15752569; DOI=10.1016/j.peptides.2004.11.002;
RA   Leite J.R.S.A., Silva L.P., Rodrigues M.I.S., Prates M.V., Brand G.D.,
RA   Lacava B.M., Azevedo R.B., Bocca A.L., Albuquerque S., Bloch C. Jr.;
RT   "Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides
RT   from the Phyllomedusa genus.";
RL   Peptides 26:565-573(2005).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Has antiprotozoal activity against T.cruzi.
CC       {ECO:0000269|PubMed:15752569}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15752569}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:15752569}.
CC   -!- MASS SPECTROMETRY: Mass=1988.15; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:15752569};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Phylloseptin subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=00760";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P84570; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..19
FT                   /note="Phylloseptin-O2"
FT                   /id="PRO_0000043826"
FT   MOD_RES         19
FT                   /note="Serine amide"
FT                   /evidence="ECO:0000269|PubMed:15752569"
SQ   SEQUENCE   19 AA;  1989 MW;  E8D1C707AE708FD1 CRC64;
     FLSLIPHAIN AVSAIAKHS