PLS5_HUMAN
ID PLS5_HUMAN Reviewed; 271 AA.
AC A0PG75; B2RXK5;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Phospholipid scramblase family member 5;
GN Name=PLSCR5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Li X., Xie Y., Mao Y.;
RT "Cloning and characterization of a novel putative scramblase.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A0PG75-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A0PG75-2; Sequence=VSP_054160;
CC -!- DOMAIN: The N-terminal proline-rich domain (PRD) is required for
CC phospholipid scramblase activity. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the phospholipid scramblase family.
CC {ECO:0000305}.
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DR EMBL; AY436642; AAR99737.1; -; mRNA.
DR EMBL; AC116544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC157886; AAI57887.1; -; mRNA.
DR EMBL; BC171917; AAI71917.1; -; mRNA.
DR CCDS; CCDS46931.1; -. [A0PG75-1]
DR CCDS; CCDS82853.1; -. [A0PG75-2]
DR RefSeq; NP_001078889.1; NM_001085420.1. [A0PG75-1]
DR RefSeq; NP_001308174.1; NM_001321245.1. [A0PG75-2]
DR AlphaFoldDB; A0PG75; -.
DR BioGRID; 133006; 61.
DR STRING; 9606.ENSP00000390111; -.
DR PhosphoSitePlus; A0PG75; -.
DR BioMuta; PLSCR5; -.
DR PaxDb; A0PG75; -.
DR PRIDE; A0PG75; -.
DR Antibodypedia; 62410; 29 antibodies from 12 providers.
DR DNASU; 389158; -.
DR Ensembl; ENST00000443512.2; ENSP00000390111.1; ENSG00000231213.7. [A0PG75-1]
DR Ensembl; ENST00000482567.5; ENSP00000418626.1; ENSG00000231213.7. [A0PG75-2]
DR Ensembl; ENST00000492200.5; ENSP00000417184.1; ENSG00000231213.7. [A0PG75-1]
DR GeneID; 389158; -.
DR KEGG; hsa:389158; -.
DR MANE-Select; ENST00000443512.2; ENSP00000390111.1; NM_001085420.2; NP_001078889.1.
DR UCSC; uc010hvb.4; human. [A0PG75-1]
DR CTD; 389158; -.
DR GeneCards; PLSCR5; -.
DR HGNC; HGNC:19952; PLSCR5.
DR HPA; ENSG00000231213; Not detected.
DR neXtProt; NX_A0PG75; -.
DR OpenTargets; ENSG00000231213; -.
DR PharmGKB; PA134902268; -.
DR VEuPathDB; HostDB:ENSG00000231213; -.
DR eggNOG; KOG0621; Eukaryota.
DR GeneTree; ENSGT00940000161728; -.
DR HOGENOM; CLU_053024_2_0_1; -.
DR InParanoid; A0PG75; -.
DR OMA; GNQVWQP; -.
DR OrthoDB; 1015148at2759; -.
DR PhylomeDB; A0PG75; -.
DR TreeFam; TF314939; -.
DR PathwayCommons; A0PG75; -.
DR BioGRID-ORCS; 389158; 5 hits in 1058 CRISPR screens.
DR GeneWiki; PLSCR5; -.
DR GenomeRNAi; 389158; -.
DR Pharos; A0PG75; Tdark.
DR PRO; PR:A0PG75; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; A0PG75; protein.
DR Bgee; ENSG00000231213; Expressed in caudate nucleus and 18 other tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0017128; F:phospholipid scramblase activity; IBA:GO_Central.
DR GO; GO:0017121; P:plasma membrane phospholipid scrambling; IBA:GO_Central.
DR InterPro; IPR005552; Scramblase.
DR InterPro; IPR025659; Tubby-like_C.
DR PANTHER; PTHR23248; PTHR23248; 1.
DR Pfam; PF03803; Scramblase; 1.
DR SUPFAM; SSF54518; SSF54518; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..271
FT /note="Phospholipid scramblase family member 5"
FT /id="PRO_0000293720"
FT REGION 1..45
FT /note="Proline-rich domain (PRD)"
FT /evidence="ECO:0000250"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 52..63
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054160"
FT VARIANT 110
FT /note="R -> S (in dbSNP:rs12107687)"
FT /id="VAR_057700"
FT CONFLICT 82
FT /note="T -> A (in Ref. 1; AAR99737)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 271 AA; 30027 MW; 69CBE4A4E2A6DB54 CRC64;
MASKDAQNQR RGLPGFLPGA PDPDQSLPAS SNPGNQAWQL SLPLPSSFLP TVSLPPGLEY
LSQLDLIIIH QQVELLGMIL GTETSNKYEI KNSLGQRIYF AVEESICFNR TFCSTLRSCT
LRITDNSGRE VITVNRPLRC NSCWCPCYLQ ELEIQAPPGT IVGYVTQKWD PFLPKFTIQN
ANKEDILKIV GPCVTCGCFG DVDFEVKTIN EKLTIGKISK YWSGFVNDVF TNADNFGIHV
PADLDVTVKA AMIGACFLFD FMFFEHSLAG L
