ID   PLS6_PITAZ              Reviewed;          19 AA.
AC   P84939;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Phylloseptin-Az6 {ECO:0000305};
DE            Short=PLS-Az6 {ECO:0000305};
DE   AltName: Full=Phylloseptin-14 {ECO:0000303|PubMed:17553595};
DE            Short=PS-14 {ECO:0000303|PubMed:17553595};
GN   Name=psn14; Synonyms=psn-14;
OS   Pithecopus azureus (Orange-legged monkey tree frog) (Phyllomedusa azurea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=2034991;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT PHE-19.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:17553595};
RX   PubMed=17553595; DOI=10.1016/j.peptides.2007.05.001;
RA   Thompson A.H., Bjourson A.J., Orr D.F., Shaw C., McClean S.;
RT   "A combined mass spectrometric and cDNA sequencing approach to the
RT   isolation and characterization of novel antimicrobial peptides from the
RT   skin secretions of Phyllomedusa hypochondrialis azurea.";
RL   Peptides 28:1331-1343(2007).
CC   -!- FUNCTION: Has antimicrobial activity. {ECO:0000250|UniProtKB:P84566}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17553595}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:17553595}.
CC   -!- MASS SPECTROMETRY: Mass=1941.21; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:17553595};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Phylloseptin subfamily. {ECO:0000255}.
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DR   AlphaFoldDB; P84939; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..19
FT                   /note="Phylloseptin-Az6"
FT                   /evidence="ECO:0000269|PubMed:17553595"
FT                   /id="PRO_0000250575"
FT   MOD_RES         19
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:17553595"
SQ   SEQUENCE   19 AA;  1943 MW;  F4BBE797A26D8FD1 CRC64;
     FLSLIPAAIS AVSALADHF