ID   PLS6_PITHY              Reviewed;          66 AA.
AC   Q0VZ41;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Phylloseptin-H6 {ECO:0000303|PubMed:18644413};
DE            Short=PLS-H6 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=Phylloseptin-8 {ECO:0000303|PubMed:16713656};
DE            Short=PS-8 {ECO:0000250|UniProtKB:P85883};
DE   Flags: Precursor;
GN   Name=psn-8 {ECO:0000312|EMBL:CAJ76135.1};
OS   Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa
OS   hypochondrialis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=317381;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAJ76135.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 47-65, SUBCELLULAR
RP   LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND AMIDATION AT PHE-65.
RC   TISSUE=Skin {ECO:0000312|EMBL:CAJ76135.1}, and
RC   Skin secretion {ECO:0000269|PubMed:16713656};
RX   PubMed=16713656; DOI=10.1016/j.peptides.2006.04.006;
RA   Chen T., Zhou M., Gagliardo R., Walker B., Shaw C.;
RT   "Elements of the granular gland peptidome and transcriptome persist in air-
RT   dried skin of the South American orange-legged leaf frog, Phyllomedusa
RT   hypocondrialis.";
RL   Peptides 27:2129-2136(2006).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Has antimicrobial activity. {ECO:0000250|UniProtKB:P84572}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16713656}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:16713656}.
CC   -!- MASS SPECTROMETRY: Mass=2013.17; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16713656};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Phylloseptin subfamily. {ECO:0000255}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=00954";
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DR   EMBL; AM229011; CAJ76135.1; -; mRNA.
DR   AlphaFoldDB; Q0VZ41; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   InterPro; IPR016322; FSAP.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
DR   PIRSF; PIRSF001822; Dermaseptin_precursor; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Cleavage on pair of basic residues; Direct protein sequencing; Secreted;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..44
FT                   /evidence="ECO:0000269|PubMed:16713656"
FT                   /id="PRO_0000372697"
FT   PEPTIDE         47..65
FT                   /note="Phylloseptin-H6"
FT                   /evidence="ECO:0000269|PubMed:16713656"
FT                   /id="PRO_0000372698"
FT   MOD_RES         65
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:16713656"
SQ   SEQUENCE   66 AA;  7552 MW;  1DB7BCC9B0104FA4 CRC64;
     MAFLKKSLFL VLFLGLVSLS ICEEEKRETE EEEYNQEDDD KSEEKRFLSL IPTAINAVSA
     LAKHFG