PLS7_PITAZ
ID PLS7_PITAZ Reviewed; 62 AA.
AC Q0VKG9; P84940;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 26.
DE RecName: Full=Phylloseptin-Az7 {ECO:0000305};
DE Short=PLS-Az7 {ECO:0000305};
DE AltName: Full=Phylloseptin-15 {ECO:0000303|PubMed:17553595};
DE Short=PS-15 {ECO:0000303|PubMed:17553595};
DE Flags: Precursor; Fragment;
GN Name=psn15; Synonyms=ppp-15, psn-15;
OS Pithecopus azureus (Orange-legged monkey tree frog) (Phyllomedusa azurea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC Pithecopus.
OX NCBI_TaxID=2034991;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAL23474.1}
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Skin secretion {ECO:0000269|PubMed:17553595};
RX PubMed=17553595; DOI=10.1016/j.peptides.2007.05.001;
RA Thompson A.H., Bjourson A.J., Orr D.F., Shaw C., McClean S.;
RT "A combined mass spectrometric and cDNA sequencing approach to the
RT isolation and characterization of novel antimicrobial peptides from the
RT skin secretions of Phyllomedusa hypochondrialis azurea.";
RL Peptides 28:1331-1343(2007).
CC -!- FUNCTION: Has antimicrobial activity. {ECO:0000250|UniProtKB:P84572}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17553595}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000269|PubMed:17553595}.
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Phylloseptin subfamily. {ECO:0000255}.
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DR EMBL; AM292541; CAL23474.1; -; mRNA.
DR AlphaFoldDB; Q0VKG9; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR Pfam; PF03032; FSAP_sig_propep; 1.
PE 2: Evidence at transcript level;
KW Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Cleavage on pair of basic residues; Secreted; Signal.
FT SIGNAL <1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..40
FT /evidence="ECO:0000250|UniProtKB:P84572"
FT /id="PRO_0000250598"
FT PEPTIDE 43..61
FT /note="Phylloseptin-Az7"
FT /evidence="ECO:0000250"
FT /id="PRO_0000250599"
FT MOD_RES 61
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250|UniProtKB:P84572"
FT NON_TER 1
FT /evidence="ECO:0000312|EMBL:CAL23474.1"
SQ SEQUENCE 62 AA; 7040 MW; 5098217B0140E60D CRC64;
LKKSLFLVLF LGLVSLSICE EEKRETEEKE NEQEDDKSEE KRLLSLVPHA INAVSAIAKH
FG
