PLS7_PITHY
ID PLS7_PITHY Reviewed; 66 AA.
AC Q0VZ40;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Phylloseptin-H7 {ECO:0000303|PubMed:18644413};
DE Short=PLS-H7 {ECO:0000303|PubMed:18644413};
DE AltName: Full=Phylloseptin-11 {ECO:0000303|PubMed:16713656};
DE Short=PS-11 {ECO:0000303|PubMed:16713656};
DE AltName: Full=Phylloseptin-9 {ECO:0000303|PubMed:18644413, ECO:0000312|EMBL:CAJ76136.1};
DE Short=PS-9 {ECO:0000303|PubMed:18644413};
DE Flags: Precursor;
GN Name=psn-9 {ECO:0000312|EMBL:CAJ76136.1};
OS Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa
OS hypochondrialis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC Pithecopus.
OX NCBI_TaxID=317381;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 47-65, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND AMIDATION AT LEU-65.
RC TISSUE=Skin, and Skin secretion;
RX PubMed=16713656; DOI=10.1016/j.peptides.2006.04.006;
RA Chen T., Zhou M., Gagliardo R., Walker B., Shaw C.;
RT "Elements of the granular gland peptidome and transcriptome persist in air-
RT dried skin of the South American orange-legged leaf frog, Phyllomedusa
RT hypocondrialis.";
RL Peptides 27:2129-2136(2006).
RN [2]
RP NOMENCLATURE.
RX PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA Amiche M., Ladram A., Nicolas P.;
RT "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT the subfamily Phyllomedusinae.";
RL Peptides 29:2074-2082(2008).
CC -!- FUNCTION: Has antimicrobial activity. {ECO:0000250|UniProtKB:Q17UY9}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16713656}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000269|PubMed:16713656}.
CC -!- MASS SPECTROMETRY: Mass=1956.13; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:16713656};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Phylloseptin subfamily. {ECO:0000255}.
CC -!- CAUTION: There is a confusion with this peptide name. In the original
CC refence Chen et al., 2006, authors attribute this sequence to
CC Phylloseptin-11. This sequence is erroneously reproduced as
CC 'Phylloseptin-9' in Amiche et al. 2008, in the nucleotide entry, and in
CC the antimicrobial peptide database. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC URL="https://wangapd3.com/database/query_output.php?ID=00974";
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DR EMBL; AM229012; CAJ76136.1; -; mRNA.
DR AlphaFoldDB; Q0VZ40; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR InterPro; IPR016322; FSAP.
DR Pfam; PF03032; FSAP_sig_propep; 1.
DR PIRSF; PIRSF001822; Dermaseptin_precursor; 1.
PE 1: Evidence at protein level;
KW Amidation; Amphibian defense peptide; Antimicrobial;
KW Cleavage on pair of basic residues; Direct protein sequencing; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..44
FT /evidence="ECO:0000269|PubMed:16713656"
FT /id="PRO_0000376043"
FT PEPTIDE 47..65
FT /note="Phylloseptin-H7"
FT /evidence="ECO:0000269|PubMed:16713656"
FT /id="PRO_5000078224"
FT REGION 25..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 65
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:16713656"
SQ SEQUENCE 66 AA; 7461 MW; C885D758036F9DCD CRC64;
MAFLKKSLFL VLFLGLVSLS ICEEEKRETE EEENDQEEDD KSEEKRFLSL LPSLVSGAVS
LVKILG
