ID   PLS8_PHYTM              Reviewed;          19 AA.
AC   P85447;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Phylloseptin-8 {ECO:0000303|Ref.1};
DE            Short=PS-8 {ECO:0000303|Ref.1};
DE   AltName: Full=Phylloseptin-TO8 {ECO:0000305};
DE            Short=PLS-TO8 {ECO:0000305};
OS   Phyllomedusa tomopterna (Tiger-striped leaf frog) (Pithecopus tomopternus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phyllomedusa.
OX   NCBI_TaxID=248868;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT PHE-19.
RC   TISSUE=Skin secretion {ECO:0000269|Ref.1};
RA   de sa Mandel S.M., Mundim N.C.C.R., Freitas T., Silva L.P., Bloch C. Jr.;
RT   "Dermaseptins and phylloseptins of Phyllomedusa (Hylidae) secretion.";
RL   Submitted (FEB-2008) to UniProtKB.
CC   -!- FUNCTION: Has antimicrobial activity. {ECO:0000250|UniProtKB:P84572}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands. {ECO:0000269|Ref.1}.
CC   -!- MASS SPECTROMETRY: Mass=2048.17; Mass_error=0.3; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Phylloseptin subfamily. {ECO:0000255}.
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DR   AlphaFoldDB; P85447; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..19
FT                   /note="Phylloseptin-8"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000389546"
FT   MOD_RES         19
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   19 AA;  2049 MW;  F4A1C707A9008FD1 CRC64;
     FLSLIPHAIN AVSALAKHF