ID   PLS9_PITHY              Reviewed;          66 AA.
AC   Q0VZ38; P84905;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Phylloseptin-H9 {ECO:0000303|PubMed:18644413};
DE            Short=PLS-H9 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=Phylloseptin-11 {ECO:0000303|PubMed:18644413, ECO:0000312|EMBL:CAJ76138.1};
DE            Short=PLS-11 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=Phylloseptin-9 {ECO:0000303|PubMed:16713656};
DE            Short=PS-9 {ECO:0000303|PubMed:16713656};
DE   Flags: Precursor;
GN   Name=psn-11 {ECO:0000312|EMBL:CAJ76138.1};
OS   Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa
OS   hypochondrialis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=317381;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 47-65, SUBCELLULAR
RP   LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND AMIDATION AT LEU-65.
RC   TISSUE=Skin, and Skin secretion;
RX   PubMed=16713656; DOI=10.1016/j.peptides.2006.04.006;
RA   Chen T., Zhou M., Gagliardo R., Walker B., Shaw C.;
RT   "Elements of the granular gland peptidome and transcriptome persist in air-
RT   dried skin of the South American orange-legged leaf frog, Phyllomedusa
RT   hypocondrialis.";
RL   Peptides 27:2129-2136(2006).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 47-65, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT LEU-65.
RC   TISSUE=Skin secretion {ECO:0000269|Ref.2};
RA   Silva L.P., Brand G.D., Bloch C. Jr.;
RT   "High-throughput co-localization of peptides and proteins by imaging mass
RT   spectrometry.";
RL   Submitted (JUL-2006) to UniProtKB.
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Has antimicrobial activity. {ECO:0000250|UniProtKB:Q17UY9}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16713656,
CC       ECO:0000269|Ref.2}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:16713656, ECO:0000269|Ref.2}.
CC   -!- MASS SPECTROMETRY: Mass=1940.40; Mass_error=0.1; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.2};
CC   -!- MASS SPECTROMETRY: Mass=1941.16; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16713656};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Phylloseptin subfamily. {ECO:0000255}.
CC   -!- CAUTION: There is a confusion with this peptide name. In the original
CC       refence Chen et al., 2006, authors attribute this sequence to
CC       Phylloseptin-9. This sequence is erroneously reproduced as
CC       'Phylloseptin-11' in Amiche et al. 2008, in the nucleotide entry, and
CC       in the antimicrobial peptide database. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=00976";
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DR   EMBL; AM229014; CAJ76138.1; -; mRNA.
DR   AlphaFoldDB; Q0VZ38; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   InterPro; IPR016322; FSAP.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
DR   PIRSF; PIRSF001822; Dermaseptin_precursor; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antimicrobial;
KW   Cleavage on pair of basic residues; Direct protein sequencing; Secreted;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..44
FT                   /evidence="ECO:0000269|PubMed:16713656, ECO:0000269|Ref.2"
FT                   /id="PRO_0000376041"
FT   PEPTIDE         47..65
FT                   /note="Phylloseptin-H9"
FT                   /evidence="ECO:0000269|PubMed:16713656, ECO:0000269|Ref.2"
FT                   /id="PRO_5000078228"
FT   REGION          24..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         65
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:16713656, ECO:0000269|Ref.2"
SQ   SEQUENCE   66 AA;  7446 MW;  C89F0EF8073E9DCD CRC64;
     MAFLKKSLFL VLFLGLVSLS ICEEEKRETE EEENDQEEDD KSEEKRFLGL LPSIVSGAVS
     LVKKLG