ID   PLSB1_MYCTU             Reviewed;         621 AA.
AC   P9WI59; L0T8L2; P65734; Q10775;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Putative acyltransferase plsB1;
GN   Name=plsB1; OrderedLocusNames=Rv1551; ORFNames=MTCY48.14c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- DOMAIN: The HXXXXD motif is essential for acyltransferase activity and
CC       may constitute the binding site for the phosphate moiety of the
CC       glycerol-3-phosphate. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the GPAT/DAPAT family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44315.1; -; Genomic_DNA.
DR   PIR; D70762; D70762.
DR   RefSeq; NP_216067.1; NC_000962.3.
DR   RefSeq; WP_003407762.1; NZ_NVQJ01000004.1.
DR   AlphaFoldDB; P9WI59; -.
DR   SMR; P9WI59; -.
DR   STRING; 83332.Rv1551; -.
DR   PaxDb; P9WI59; -.
DR   DNASU; 886382; -.
DR   GeneID; 886382; -.
DR   KEGG; mtu:Rv1551; -.
DR   TubercuList; Rv1551; -.
DR   eggNOG; COG2937; Bacteria.
DR   OMA; RFNLEWY; -.
DR   PhylomeDB; P9WI59; -.
DR   BRENDA; 2.3.1.15; 3445.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0004366; F:glycerol-3-phosphate O-acyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006631; P:fatty acid metabolic process; IBA:GO_Central.
DR   GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IBA:GO_Central.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IBA:GO_Central.
DR   GO; GO:0019432; P:triglyceride biosynthetic process; IBA:GO_Central.
DR   CDD; cd07993; LPLAT_DHAPAT-like; 1.
DR   InterPro; IPR022284; GPAT/DHAPAT.
DR   InterPro; IPR041728; GPAT/DHAPAT_LPLAT.
DR   InterPro; IPR045520; GPAT_C.
DR   InterPro; IPR028354; GPAT_PlsB.
DR   InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR   PANTHER; PTHR12563; PTHR12563; 1.
DR   Pfam; PF01553; Acyltransferase; 1.
DR   Pfam; PF19277; GPAT_C; 1.
DR   PIRSF; PIRSF500064; GPAT; 1.
DR   PIRSF; PIRSF000437; GPAT_DHAPAT; 1.
DR   SMART; SM00563; PlsC; 1.
PE   1: Evidence at protein level;
KW   Acyltransferase; Cell membrane; Membrane; Reference proteome; Transferase.
FT   CHAIN           1..621
FT                   /note="Putative acyltransferase plsB1"
FT                   /id="PRO_0000195244"
FT   MOTIF           123..128
FT                   /note="HXXXXD motif"
SQ   SEQUENCE   621 AA;  69224 MW;  05E005BB5B6E241D CRC64;
     MTAREVGRIG LRKLLQRIGI VAESMTPLAT DPVEVTQLLD ARWYDERLRA LADELGRDPD
     SVRAEAAGYL REMAASLDER AVQAWRGFSR WLMRAYDVLV DEDQITQLRK LDRKATLAFA
     FSHRSYLDGM LLPEAILANR LSPALTFGGA NLNFFPMGAW AKRTGAIFIR RQTKDIPVYR
     FVLRAYAAQL VQNHVNLTWS IEGGRTRTGK LRPPVFGILR YITDAVDEID GPEVYLVPTS
     IVYDQLHEVE AMTTEAYGAV KRPEDLRFLV RLARQQGERL GRAYLDFGEP LPLRKRLQEM
     RADKSGTGSE IERIALDVEH RINRATPVTP TAVVSLALLG ADRSLSISEV LATVRPLASY
     IAARNWAVAG AADLTNRSTI RWTLHQMVAS GVVSVYDAGT EAVWGIGEDQ HLVAAFYRNT
     AIHILVDRAV AELALLAAAE TTTNGSVSPA TVRDEALSLR DLLKFEFLFS GRAQFEKDLA
     NEVLLIGSVV DTSKPAAAAD VWRLLESADV LLAHLVLRPF LDAYHIVADR LAAHEDDSFD
     EEGFLAECLQ VGKQWELQRN IASAESRSME LFKTALRLAR HRELVDGADA TDIAKRRQQF
     ADEIATATRR VNTIAELARR Q