ID   A7L3B_MOUSE             Reviewed;          97 AA.
AC   Q3UD01;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Ataxin-7-like protein 3B;
GN   Name=Atxn7l3b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Bone marrow, and Muellerian duct;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=16680195; DOI=10.1371/journal.pcbi.0020046;
RA   Svensson O., Arvestad L., Lagergren J.;
RT   "Genome-wide survey for biologically functional pseudogenes.";
RL   PLoS Comput. Biol. 2:E46-E46(2006).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas, Spleen,
RC   and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: By binding to ENY2, interferes with the nuclear functions of
CC       the deubiquitinase (DUB) module of the SAGA complex which consists of
CC       ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22.
CC       Affects USP22 DUB activity toward histones indirectly by changing the
CC       subcellular distribution of ENY2 and altering ENY2 availability for
CC       ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels
CC       through cytoplasmic sequestration of ENY2 resulting in loss of nuclear
CC       ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein
CC       expression levels of ENY2 and ATXN7L3. {ECO:0000250|UniProtKB:Q96GX2}.
CC   -!- SUBUNIT: Interacts strongly with ENY2. Interacts weakly with USP22.
CC       {ECO:0000250|UniProtKB:Q96GX2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96GX2}.
CC   -!- MISCELLANEOUS: Encoded by an expressed retrotransposed copy of the
CC       Atxn7l3 locus that emerged prior to the speciation event separating
CC       primates and rodents.
CC   -!- SIMILARITY: Belongs to the SGF11 family. {ECO:0000305}.
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DR   EMBL; AK135540; BAE22575.1; -; mRNA.
DR   EMBL; AK150316; BAE29461.1; -; mRNA.
DR   CCDS; CCDS36060.1; -.
DR   RefSeq; NP_001028646.2; NM_001033474.2.
DR   AlphaFoldDB; Q3UD01; -.
DR   STRING; 10090.ENSMUSP00000096882; -.
DR   iPTMnet; Q3UD01; -.
DR   PhosphoSitePlus; Q3UD01; -.
DR   EPD; Q3UD01; -.
DR   MaxQB; Q3UD01; -.
DR   PaxDb; Q3UD01; -.
DR   PeptideAtlas; Q3UD01; -.
DR   PRIDE; Q3UD01; -.
DR   ProteomicsDB; 286035; -.
DR   Antibodypedia; 52794; 55 antibodies from 12 providers.
DR   DNASU; 382423; -.
DR   Ensembl; ENSMUST00000099276; ENSMUSP00000096882; ENSMUSG00000074748.
DR   GeneID; 382423; -.
DR   KEGG; mmu:382423; -.
DR   UCSC; uc007has.1; mouse.
DR   CTD; 552889; -.
DR   MGI; MGI:1914971; Atxn7l3b.
DR   VEuPathDB; HostDB:ENSMUSG00000074748; -.
DR   eggNOG; ENOG502TFV2; Eukaryota.
DR   GeneTree; ENSGT00940000162576; -.
DR   HOGENOM; CLU_2359075_0_0_1; -.
DR   InParanoid; Q3UD01; -.
DR   OMA; QRAPPDF; -.
DR   OrthoDB; 1244885at2759; -.
DR   PhylomeDB; Q3UD01; -.
DR   TreeFam; TF353123; -.
DR   BioGRID-ORCS; 382423; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Atxn7l3b; mouse.
DR   PRO; PR:Q3UD01; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q3UD01; protein.
DR   Bgee; ENSMUSG00000074748; Expressed in rostral migratory stream and 264 other tissues.
DR   Genevisible; Q3UD01; MM.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0010468; P:regulation of gene expression; ISS:UniProtKB.
DR   InterPro; IPR042933; ATXN7L3B.
DR   PANTHER; PTHR47733; PTHR47733; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..97
FT                   /note="Ataxin-7-like protein 3B"
FT                   /id="PRO_0000392530"
FT   REGION          76..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         92
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
SQ   SEQUENCE   97 AA;  10731 MW;  6E4A40700ECFA57D CRC64;
     MEEISLANLD TNKLEAIAQE IYVDLIEDSC LGFCFEVHRA VKCGYFYLEF ADTGSVKDFG
     IQPVEDKGAC RLPLCSLPGD PGDGPQTELQ RSPPEFQ