ASTG_PSEAE
ID ASTG_PSEAE Reviewed; 340 AA.
AC P80358;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1999, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Arginine N-succinyltransferase subunit beta;
DE EC=2.3.1.109;
DE AltName: Full=AOST;
DE Short=AST;
DE AltName: Full=ARUAII;
GN Name=aruG; OrderedLocusNames=PA0897;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=9393691; DOI=10.1128/jb.179.23.7280-7290.1997;
RA Itoh Y.;
RT "Cloning and characterization of the aru genes encoding enzymes of the
RT catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa.";
RL J. Bacteriol. 179:7280-7290(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [3]
RP PROTEIN SEQUENCE OF 1-15.
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=7523119; DOI=10.1111/j.1432-1033.1994.00853.x;
RA Tricot C., Vander Wauven C., Wattiez R., Falmagne P., Stalon V.;
RT "Purification and properties of a succinyltransferase from Pseudomonas
RT aeruginosa specific for both arginine and ornithine.";
RL Eur. J. Biochem. 224:853-861(1994).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine + succinyl-CoA = CoA + H(+) + N(2)-succinyl-L-
CC arginine; Xref=Rhea:RHEA:15185, ChEBI:CHEBI:15378, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:58241;
CC EC=2.3.1.109;
CC -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC pathway; L-glutamate and succinate from L-arginine: step 1/5.
CC -!- SUBUNIT: Heterotetramer of two alpha and two beta subunits.
CC -!- SIMILARITY: Belongs to the succinylarginine dihydrolase family.
CC {ECO:0000305}.
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DR EMBL; AF011922; AAC46011.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG04286.1; -; Genomic_DNA.
DR PIR; B83533; B83533.
DR RefSeq; NP_249588.1; NC_002516.2.
DR RefSeq; WP_003112607.1; NZ_QZGE01000007.1.
DR AlphaFoldDB; P80358; -.
DR SMR; P80358; -.
DR STRING; 287.DR97_1046; -.
DR PaxDb; P80358; -.
DR PRIDE; P80358; -.
DR EnsemblBacteria; AAG04286; AAG04286; PA0897.
DR GeneID; 883082; -.
DR KEGG; pae:PA0897; -.
DR PATRIC; fig|208964.12.peg.932; -.
DR PseudoCAP; PA0897; -.
DR HOGENOM; CLU_057655_0_0_6; -.
DR InParanoid; P80358; -.
DR OMA; RFFSMEF; -.
DR PhylomeDB; P80358; -.
DR BioCyc; MetaCyc:MON-11525; -.
DR BioCyc; PAER208964:G1FZ6-913-MON; -.
DR BRENDA; 2.3.1.109; 5087.
DR UniPathway; UPA00185; UER00279.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0008791; F:arginine N-succinyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006527; P:arginine catabolic process; IDA:PseudoCAP.
DR GO; GO:0019545; P:arginine catabolic process to succinate; IEA:UniProtKB-UniPathway.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR007041; Arg_succinylTrfase_AstA/AruG.
DR InterPro; IPR017650; Arginine_N-succinylTrfase.
DR Pfam; PF04958; AstA; 1.
DR SUPFAM; SSF55729; SSF55729; 1.
DR TIGRFAMs; TIGR03243; arg_catab_AOST; 1.
DR TIGRFAMs; TIGR03244; arg_catab_AstA; 1.
PE 1: Evidence at protein level;
KW Acyltransferase; Arginine metabolism; Direct protein sequencing;
KW Reference proteome; Transferase.
FT CHAIN 1..340
FT /note="Arginine N-succinyltransferase subunit beta"
FT /id="PRO_0000064717"
SQ SEQUENCE 340 AA; 37245 MW; B87B6626166DD49A CRC64;
MIVRPVTSAD LPALIELARS TGTGLTTLPA NEQRLQHRVS WAEKAFRGEA ERGDADYLFV
LEDDAGKVVG ISAIAGAVGL REPWYNYRVG LTVSASQELN IHREIPTLFL ANDLTGNSEL
CSLFLHADHR SGLNGKLLSR ARFLFIAEFR HLFGDKLIAE MRGMSDEEGR SPFWESLGRH
FFKMEFSQAD YLTGVGNKAF IAELMPKFPL YTCFLSEEAR GVIGRVHPNT EPALAMLKAE
GFSYQGYVDI FDAGPAIEAE TDKIRAIAES QNLVLAVGTP GDDAEPYLIH NRKREDCRIT
AAPARAAAGT LVVDPLTAKR LRLSAGASVR AVPLSAQKRG
