ASTN1_HUMAN
ID ASTN1_HUMAN Reviewed; 1302 AA.
AC O14525; A5PL12; B4DHI9; E9PFR8; O60799; Q5W0V7; Q5W0V8;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 3.
DT 03-AUG-2022, entry version 185.
DE RecName: Full=Astrotactin-1;
DE Flags: Precursor;
GN Name=ASTN1; Synonyms=ASTN, KIAA0289;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS ARG-932
RP AND GLN-942.
RC TISSUE=Brain;
RX PubMed=9179496; DOI=10.1093/dnares/4.1.53;
RA Ohara O., Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N.,
RA Nomura N.;
RT "Construction and characterization of human brain cDNA libraries suitable
RT for analysis of cDNA clones encoding relatively large proteins.";
RL DNA Res. 4:53-59(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANTS ARG-932
RP AND GLN-942.
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANTS ARG-932
RP AND GLN-942.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Neuronal adhesion molecule that is required for normal
CC migration of young postmitotic neuroblasts along glial fibers,
CC especially in the cerebellum. Required for normal rate of migration of
CC granule cells during brain development and for normal cerebellum
CC development. {ECO:0000250|UniProtKB:Q61137}.
CC -!- SUBUNIT: Interacts with ASTN2; the interaction is not calcium-
CC dependent. {ECO:0000250|UniProtKB:Q61137}.
CC -!- INTERACTION:
CC O14525-2; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-21977454, EBI-742054;
CC O14525-2; Q14145: KEAP1; NbExp=4; IntAct=EBI-21977454, EBI-751001;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q61137};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q61137}. Perikaryon
CC {ECO:0000250|UniProtKB:Q61137}. Endosome
CC {ECO:0000250|UniProtKB:Q61137}. Cytoplasmic vesicle, clathrin-coated
CC vesicle {ECO:0000250|UniProtKB:Q61137}. Note=Detected close to the
CC anterior pole and at the base of the leading process in migrating
CC neurons. Is internalized from the membrane via clathrin-coated vesicles
CC and endosomes, and recycled to the anterior pole of the migrating cell.
CC {ECO:0000250|UniProtKB:Q61137}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=2;
CC IsoId=O14525-1; Sequence=Displayed;
CC Name=1;
CC IsoId=O14525-2; Sequence=VSP_001371;
CC Name=3;
CC IsoId=O14525-3; Sequence=VSP_001371, VSP_045069;
CC -!- SIMILARITY: Belongs to the astrotactin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA22958.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB006627; BAA22958.1; ALT_INIT; mRNA.
DR EMBL; AK295126; BAG58151.1; -; mRNA.
DR EMBL; AL021398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL022145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL031290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL136983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471067; EAW91007.1; -; Genomic_DNA.
DR EMBL; BC142697; AAI42698.1; -; mRNA.
DR CCDS; CCDS1319.1; -. [O14525-2]
DR CCDS; CCDS44280.1; -. [O14525-3]
DR PIR; T00038; T00038.
DR RefSeq; NP_996991.1; NM_207108.2. [O14525-3]
DR RefSeq; XP_016856829.1; XM_017001340.1.
DR AlphaFoldDB; O14525; -.
DR SMR; O14525; -.
DR BioGRID; 106952; 6.
DR IntAct; O14525; 6.
DR STRING; 9606.ENSP00000354536; -.
DR TCDB; 9.B.87.2.1; the selenoprotein p receptor (selp-receptor) family.
DR GlyGen; O14525; 6 sites.
DR iPTMnet; O14525; -.
DR PhosphoSitePlus; O14525; -.
DR BioMuta; ASTN1; -.
DR EPD; O14525; -.
DR MassIVE; O14525; -.
DR PaxDb; O14525; -.
DR PeptideAtlas; O14525; -.
DR PRIDE; O14525; -.
DR ProteomicsDB; 20161; -.
DR ProteomicsDB; 48071; -. [O14525-1]
DR ProteomicsDB; 48072; -. [O14525-2]
DR Antibodypedia; 55629; 20 antibodies from 12 providers.
DR DNASU; 460; -.
DR Ensembl; ENST00000361833.7; ENSP00000354536.2; ENSG00000152092.16. [O14525-2]
DR Ensembl; ENST00000424564.2; ENSP00000395041.2; ENSG00000152092.16. [O14525-3]
DR GeneID; 460; -.
DR KEGG; hsa:460; -.
DR MANE-Select; ENST00000361833.7; ENSP00000354536.2; NM_004319.3; NP_004310.1. [O14525-2]
DR UCSC; uc001glc.5; human. [O14525-1]
DR CTD; 460; -.
DR DisGeNET; 460; -.
DR GeneCards; ASTN1; -.
DR HGNC; HGNC:773; ASTN1.
DR HPA; ENSG00000152092; Tissue enhanced (adrenal gland, brain, retina).
DR MIM; 600904; gene.
DR neXtProt; NX_O14525; -.
DR OpenTargets; ENSG00000152092; -.
DR PharmGKB; PA162376961; -.
DR VEuPathDB; HostDB:ENSG00000152092; -.
DR eggNOG; ENOG502R4QT; Eukaryota.
DR GeneTree; ENSGT00390000003140; -.
DR HOGENOM; CLU_006316_1_0_1; -.
DR InParanoid; O14525; -.
DR OMA; ISMIVRC; -.
DR OrthoDB; 39300at2759; -.
DR PhylomeDB; O14525; -.
DR TreeFam; TF332034; -.
DR PathwayCommons; O14525; -.
DR SignaLink; O14525; -.
DR BioGRID-ORCS; 460; 11 hits in 1071 CRISPR screens.
DR ChiTaRS; ASTN1; human.
DR GenomeRNAi; 460; -.
DR Pharos; O14525; Tbio.
DR PRO; PR:O14525; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O14525; protein.
DR Bgee; ENSG00000152092; Expressed in postcentral gyrus and 140 other tissues.
DR ExpressionAtlas; O14525; baseline and differential.
DR Genevisible; O14525; HS.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0007158; P:neuron cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0001764; P:neuron migration; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR InterPro; IPR040685; Annexin-like.
DR InterPro; IPR045574; ASTN1_2_EGF_Fn.
DR InterPro; IPR045575; ASTN_1_2_N.
DR InterPro; IPR026995; Astrotactin.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR020864; MACPF.
DR PANTHER; PTHR16592; PTHR16592; 1.
DR Pfam; PF18411; Annexin_like; 1.
DR Pfam; PF19743; ASTN1_2_EGF_Fn; 1.
DR Pfam; PF19441; ASTN_1_2_N; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell adhesion; Cell membrane; Cytoplasmic vesicle;
KW Disulfide bond; EGF-like domain; Endosome; Glycoprotein; Membrane;
KW Methylation; Phosphoprotein; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..1302
FT /note="Astrotactin-1"
FT /id="PRO_0000007481"
FT TOPO_DOM 22..153
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..383
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 384..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 403..1302
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:O75129"
FT DOMAIN 459..507
FT /note="EGF-like 1"
FT DOMAIN 608..652
FT /note="EGF-like 2"
FT DOMAIN 656..708
FT /note="EGF-like 3"
FT DOMAIN 1030..1145
FT /note="Fibronectin type-III"
FT REGION 340..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 227
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q61137"
FT MOD_RES 337
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q61137"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 453
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 729
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 742
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 804
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 984
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 463..475
FT /evidence="ECO:0000250"
FT DISULFID 471..490
FT /evidence="ECO:0000250"
FT DISULFID 492..506
FT /evidence="ECO:0000250"
FT DISULFID 612..625
FT /evidence="ECO:0000250"
FT DISULFID 619..636
FT /evidence="ECO:0000250"
FT DISULFID 638..651
FT /evidence="ECO:0000250"
FT DISULFID 660..672
FT /evidence="ECO:0000250"
FT DISULFID 668..692
FT /evidence="ECO:0000250"
FT DISULFID 694..707
FT /evidence="ECO:0000250"
FT DISULFID 785..951
FT /evidence="ECO:0000250|UniProtKB:O75129"
FT DISULFID 876..941
FT /evidence="ECO:0000250|UniProtKB:O75129"
FT DISULFID 947..954
FT /evidence="ECO:0000250|UniProtKB:O75129"
FT DISULFID 1000..1011
FT /evidence="ECO:0000250|UniProtKB:O75129"
FT DISULFID 1013..1026
FT /evidence="ECO:0000250|UniProtKB:O75129"
FT DISULFID 1101..1121
FT /evidence="ECO:0000250|UniProtKB:O75129"
FT DISULFID 1153..1240
FT /evidence="ECO:0000250|UniProtKB:O75129"
FT DISULFID 1261..1284
FT /evidence="ECO:0000250|UniProtKB:O75129"
FT VAR_SEQ 480..487
FT /note="Missing (in isoform 1 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:9179496"
FT /id="VSP_001371"
FT VAR_SEQ 1225..1302
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_045069"
FT VARIANT 932
FT /note="H -> R (in dbSNP:rs2228956)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9179496"
FT /id="VAR_069030"
FT VARIANT 942
FT /note="H -> Q (in dbSNP:rs2281180)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9179496"
FT /id="VAR_069031"
FT VARIANT 1270
FT /note="G -> R (in dbSNP:rs12118933)"
FT /id="VAR_036764"
FT VARIANT 1278
FT /note="R -> G (in dbSNP:rs12118933)"
FT /id="VAR_055713"
FT CONFLICT 439
FT /note="D -> E (in Ref. 2; BAG58151)"
FT /evidence="ECO:0000305"
FT CONFLICT 994
FT /note="T -> I (in Ref. 2; BAG58151)"
FT /evidence="ECO:0000305"
FT CONFLICT O14525-3:1216
FT /note="R -> RYQ (in Ref. 2; BAG58151)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1302 AA; 144913 MW; CA9EDDA6621C4F3B CRC64;
MALAGLCALL ACCWGPAAVL ATAAGDVDPS KELECKLKSI TVSALPFLRE NDLSIMHSPS
ASEPKLLFSV RNDFPGEMVV VDDLENTELP YFVLEISGNT EDIPLVRWRQ QWLENGTLLF
HIHHQDGAPS LPGQDPTEEP QHESAEEELR ILHISVMGGM IALLLSILCL VMILYTRRRW
CKRRRVPQPQ KSASAEAANE IHYIPSVLIG GHGRESLRNA RVQGHNSSGT LSIRETPILD
GYEYDITDLR HHLQRECMNG GEDFASQVTR TLDSLQGCNE KSGMDLTPGS DNAKLSLMNK
YKDNIIATSP VDSNHQQATL LSHTSSSQRK RINNKARAGS AFLNPEGDSG TEAENDPQLT
FYTDPSRSRR RSRVGSPRSP VNKTTLTLIS ITSCVIGLVC SSHVNCPLVV KITLHVPEHL
IADGSRFILL EGSQLDASDW LNPAQVVLFS QQNSSGPWAM DLCARRLLDP CEHQCDPETG
RREHRAAGEC LCYEGYMKDP VHKHLCIRNE WGTNQGPWPY TIFQRGFDLV LGEQPSDKIF
RFTYTLGEGM WLPLSKSFVI PPAELAINPS AKCKTDMTVM EDAVEVREEL MTSSSFDSLE
VLLDSFGPVR DCSKDNGGCS KNFRCISDRK LDSTGCVCPS GLSPMKDSSG CYDRHIGVDC
SDGFNGGCEQ LCLQQMAPFP DDPTLYNILM FCGCIEDYKL GVDGRSCQLI TETCPEGSDC
GESRELPMNQ TLFGEMFFGY NNHSKEVAAG QVLKGTFRQN NFARGLDQQL PDGLVVATVP
LENQCLEEIS EPTPDPDFLT GMVNFSEVSG YPVLQHWKVR SVMYHIKLNQ VAISQALSNA
LHSLDGATSR ADFVALLDQF GNHYIQEAIY GFEESCSIWY PNKQVQRRLW LEYEDISKGN
SPSDESEERE RDPKVLTFPE YITSLSDSGT KHMAAGVRME CHSKGRCPSS CPLCHVTSSP
DTPAEPVLLE VTKAAPIYEL VTNNQTQRLL QEATMSSLWC SGTGDVIEDW CRCDSTAFGA
DGLPTCAPLP QPVLRLSTVH EPSSTLVVLE WEHSEPPIGV QIVDYLLRQE KVTDRMDHSK
VETETVLSFV DDIISGAKSP CAMPSQVPDK QLTTISLIIR CLEPDTIYMF TLWGVDNTGR
RSRPSDVIVK TPCPVVDDVK AQEIADKIYN LFNGYTSGKE QQTAYNTLLD LGSPTLHRVL
YHYNQHYESF GEFTWRCEDE LGPRKAGLIL SQLGDLSSWC NGLLQEPKIS LRRSSLKYLG
CRYSEIKPYG LDWAELSRDL RKTCEEQTLS IPYNDYGDSK EI
