ID   ASURF_HUMAN             Reviewed;          96 AA.
AC   L0R819;
DT   22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2013, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=ASNSD1 upstream open reading frame protein {ECO:0000312|HGNC:HGNC:53619};
DE   AltName: Full=ASNSD1 small/short open reading frame-encoded polypeptide {ECO:0000303|PubMed:23160002, ECO:0000303|PubMed:25857697};
DE            Short=ASNSD1-SEP {ECO:0000303|PubMed:23160002, ECO:0000303|PubMed:25857697};
GN   Name=ASDURF {ECO:0000312|HGNC:HGNC:53619};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000312|EMBL:CCO13681.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE INITIATION (ISOFORM 2).
RX   PubMed=23950983; DOI=10.1371/journal.pone.0070698;
RA   Vanderperre B., Lucier J.-F., Motard J., Tremblay G., Vanderperre S.,
RA   Wisztorski M., Salzet M., Boisvert F.-M., Roucou X.;
RT   "Direct detection of alternative open reading frames translation products
RT   in human significantly expands the proteome.";
RL   PLoS ONE 8:E70698-E70698(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   ALTERNATIVE INITIATION (ISOFORM 2), SUBCELLULAR LOCATION (ISOFORM 2), AND
RP   IDENTIFICATION BY MASS SPECTROMETRY (ISOFORM 2).
RX   PubMed=23160002; DOI=10.1038/nchembio.1120;
RA   Slavoff S.A., Mitchell A.J., Schwaid A.G., Cabili M.N., Ma J., Levin J.Z.,
RA   Karger A.D., Budnik B.A., Rinn J.L., Saghatelian A.;
RT   "Peptidomic discovery of short open reading frame-encoded peptides in human
RT   cells.";
RL   Nat. Chem. Biol. 9:59-64(2013).
RN   [4]
RP   ALTERNATIVE INITIATION (ISOFORM 2).
RX   PubMed=25857697; DOI=10.3109/10409238.2015.1016215;
RA   Chu Q., Ma J., Saghatelian A.;
RT   "Identification and characterization of sORF-encoded polypeptides.";
RL   Crit. Rev. Biochem. Mol. Biol. 50:134-141(2015).
RN   [5]
RP   IDENTIFICATION IN THE PAQOSOME COMPLEX, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=31738558; DOI=10.1021/acs.jproteome.9b00599;
RA   Cloutier P., Poitras C., Faubert D., Bouchard A., Blanchette M.,
RA   Gauthier M.S., Coulombe B.;
RT   "Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the
RT   PAQosome.";
RL   J. Proteome Res. 19:18-27(2020).
CC   -!- SUBUNIT: Component of the PAQosome complex which is responsible for the
CC       biogenesis of several protein complexes and which consists of R2TP
CC       complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members
CC       PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and
CC       DNAAF10/WDR92. {ECO:0000269|PubMed:31738558}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23160002}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=2; Synonyms=uORF {ECO:0000303|PubMed:23160002};
CC         IsoId=L0R819-1; Sequence=Displayed;
CC       Name=1;
CC         IsoId=Q9NWL6-1; Sequence=External;
CC   -!- MISCELLANEOUS: [Isoform 2]: Product of the upstream open reading frame
CC       of this bicistronic gene. {ECO:0000303|PubMed:23160002,
CC       ECO:0000303|PubMed:23950983, ECO:0000303|PubMed:25857697}.
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DR   EMBL; HF547970; CCO13681.1; -; Genomic_DNA.
DR   EMBL; AC012488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS86901.1; -. [L0R819-1]
DR   AlphaFoldDB; L0R819; -.
DR   SMR; L0R819; -.
DR   ComplexPortal; CPX-6145; PAQosome co-chaperone complex.
DR   IntAct; L0R819; 1.
DR   BioMuta; HGNC:53619; -.
DR   EPD; L0R819; -.
DR   jPOST; L0R819; -.
DR   MassIVE; L0R819; -.
DR   PeptideAtlas; L0R819; -.
DR   PRIDE; L0R819; -.
DR   Ensembl; ENST00000607829.6; ENSP00000475224.1; ENSG00000286053.2. [L0R819-1]
DR   MANE-Select; ENST00000607829.6; ENSP00000475224.1; NM_001353493.2; NP_001340422.1.
DR   UCSC; uc061qov.1; human. [L0R819-1]
DR   GeneCards; ASDURF; -.
DR   HGNC; HGNC:53619; ASDURF.
DR   HPA; ENSG00000286053; Low tissue specificity.
DR   MIM; 619740; gene.
DR   neXtProt; NX_L0R819; -.
DR   VEuPathDB; HostDB:ENSG00000286053; -.
DR   GeneTree; ENSGT01030000234770; -.
DR   HOGENOM; CLU_2359108_0_0_1; -.
DR   OMA; LSQCKNT; -.
DR   SignaLink; L0R819; -.
DR   Pharos; L0R819; Tdark.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000286053; Expressed in calcaneal tendon and 97 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:1990062; C:RPAP3/R2TP/prefoldin-like complex; IPI:ComplexPortal.
DR   GO; GO:0050821; P:protein stabilization; IC:ComplexPortal.
DR   Gene3D; 1.10.287.370; -; 1.
DR   InterPro; IPR009053; Prefoldin.
PE   1: Evidence at protein level;
KW   Alternative initiation; Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..96
FT                   /note="ASNSD1 upstream open reading frame protein"
FT                   /id="PRO_0000442240"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          23..96
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   96 AA;  11250 MW;  87905E0870BB4731 CRC64;
     MPSRGTRPED SSVLIPTDNS TPHKEDLSSK IKEQKIVVDE LSNLKKNRKV YRQQQNSNIF
     FLADRTEMLS ESKNILDELK KEYQEIENLD KTKIKK