ASXL3_HUMAN
ID ASXL3_HUMAN Reviewed; 2248 AA.
AC Q9C0F0; Q6ZMX6; Q96MU3; Q9UFC5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Putative Polycomb group protein ASXL3;
DE AltName: Full=Additional sex combs-like protein 3;
GN Name=ASXL3; Synonyms=KIAA1713;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1632-2248 (ISOFORM 1), AND VARIANT VAL-1708.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 597-2248, AND VARIANTS SER-954
RP AND VAL-1708.
RC TISSUE=Brain;
RX PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:347-355(2000).
RN [4]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 818-1238 (ISOFORM 1), AND VARIANT
RP SER-954.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=15138607;
RA Katoh M., Katoh M.;
RT "Identification and characterization of ASXL3 gene in silico.";
RL Int. J. Oncol. 24:1617-1622(2004).
RN [7]
RP INVOLVEMENT IN BRPS.
RX PubMed=23383720; DOI=10.1186/gm415;
RA Bainbridge M.N., Hu H., Muzny D.M., Musante L., Lupski J.R., Graham B.H.,
RA Chen W., Gripp K.W., Jenny K., Wienker T.F., Yang Y., Sutton V.R.,
RA Gibbs R.A., Ropers H.H.;
RT "De novo truncating mutations in ASXL3 are associated with a novel clinical
RT phenotype with similarities to Bohring-Opitz syndrome.";
RL Genome Med. 5:11-11(2013).
RN [8]
RP VARIANT 1109-LYS--ARG-2248 DEL.
RX PubMed=30158690; DOI=10.1038/s41436-018-0085-6;
RG DDD Study;
RA Yuan B., Neira J., Pehlivan D., Santiago-Sim T., Song X., Rosenfeld J.,
RA Posey J.E., Patel V., Jin W., Adam M.P., Baple E.L., Dean J., Fong C.T.,
RA Hickey S.E., Hudgins L., Leon E., Madan-Khetarpal S., Rawlins L.,
RA Rustad C.F., Stray-Pedersen A., Tveten K., Wenger O., Diaz J., Jenkins L.,
RA Martin L., McGuire M., Pietryga M., Ramsdell L., Slattery L., Abid F.,
RA Bertuch A.A., Grange D., Immken L., Schaaf C.P., Van Esch H., Bi W.,
RA Cheung S.W., Breman A.M., Smith J.L., Shaw C., Crosby A.H., Eng C.,
RA Yang Y., Lupski J.R., Xiao R., Liu P.;
RT "Clinical exome sequencing reveals locus heterogeneity and phenotypic
RT variability of cohesinopathies.";
RL Genet. Med. 21:663-675(2019).
CC -!- FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by
CC forming multiprotein complexes, which are required to maintain the
CC transcriptionally repressive state of homeotic genes throughout
CC development. PcG proteins are not required to initiate repression, but
CC to maintain it during later stages of development. They probably act
CC via methylation of histones, rendering chromatin heritably changed in
CC its expressibility (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9C0F0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9C0F0-2; Sequence=VSP_042433, VSP_042434;
CC -!- TISSUE SPECIFICITY: Expressed in pancreatic islets, testis,
CC neuroblastoma, head and neck tumor. {ECO:0000269|PubMed:15138607}.
CC -!- DISEASE: Bainbridge-Ropers syndrome (BRPS) [MIM:615485]: A syndrome
CC characterized by psychomotor retardation, feeding problems, severe
CC postnatal growth retardation in some patients, arched eyebrows,
CC anteverted nares, and ulnar deviation of the hands.
CC {ECO:0000269|PubMed:23383720}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Asx family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71186.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD18599.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=CAB61377.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AC023192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC010798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK056450; BAB71186.1; ALT_INIT; mRNA.
DR EMBL; AK131454; BAD18599.1; ALT_SEQ; mRNA.
DR EMBL; AB051500; BAB21804.2; -; mRNA.
DR EMBL; AL133050; CAB61377.1; ALT_SEQ; mRNA.
DR CCDS; CCDS45847.1; -. [Q9C0F0-1]
DR PIR; T42653; T42653.
DR RefSeq; NP_085135.1; NM_030632.2. [Q9C0F0-1]
DR AlphaFoldDB; Q9C0F0; -.
DR SMR; Q9C0F0; -.
DR BioGRID; 123314; 13.
DR IntAct; Q9C0F0; 4.
DR MINT; Q9C0F0; -.
DR STRING; 9606.ENSP00000269197; -.
DR iPTMnet; Q9C0F0; -.
DR PhosphoSitePlus; Q9C0F0; -.
DR BioMuta; ASXL3; -.
DR DMDM; 172046234; -.
DR EPD; Q9C0F0; -.
DR jPOST; Q9C0F0; -.
DR MassIVE; Q9C0F0; -.
DR PaxDb; Q9C0F0; -.
DR PeptideAtlas; Q9C0F0; -.
DR PRIDE; Q9C0F0; -.
DR ProteomicsDB; 80026; -. [Q9C0F0-1]
DR ProteomicsDB; 80027; -. [Q9C0F0-2]
DR Antibodypedia; 82041; 3 antibodies from 1 providers.
DR DNASU; 80816; -.
DR Ensembl; ENST00000269197.12; ENSP00000269197.4; ENSG00000141431.13. [Q9C0F0-1]
DR GeneID; 80816; -.
DR KEGG; hsa:80816; -.
DR MANE-Select; ENST00000269197.12; ENSP00000269197.4; NM_030632.3; NP_085135.1.
DR UCSC; uc010dmg.2; human. [Q9C0F0-1]
DR CTD; 80816; -.
DR DisGeNET; 80816; -.
DR GeneCards; ASXL3; -.
DR GeneReviews; ASXL3; -.
DR HGNC; HGNC:29357; ASXL3.
DR HPA; ENSG00000141431; Tissue enhanced (brain, ovary).
DR MalaCards; ASXL3; -.
DR MIM; 615115; gene.
DR MIM; 615485; phenotype.
DR neXtProt; NX_Q9C0F0; -.
DR OpenTargets; ENSG00000141431; -.
DR Orphanet; 352577; Bainbridge-Ropers syndrome.
DR PharmGKB; PA162377010; -.
DR VEuPathDB; HostDB:ENSG00000141431; -.
DR eggNOG; ENOG502QWPH; Eukaryota.
DR GeneTree; ENSGT00520000055578; -.
DR HOGENOM; CLU_001823_0_0_1; -.
DR InParanoid; Q9C0F0; -.
DR OMA; MFTGNML; -.
DR OrthoDB; 53757at2759; -.
DR PhylomeDB; Q9C0F0; -.
DR TreeFam; TF328464; -.
DR PathwayCommons; Q9C0F0; -.
DR SignaLink; Q9C0F0; -.
DR SIGNOR; Q9C0F0; -.
DR BioGRID-ORCS; 80816; 9 hits in 1066 CRISPR screens.
DR ChiTaRS; ASXL3; human.
DR GenomeRNAi; 80816; -.
DR Pharos; Q9C0F0; Tbio.
DR PRO; PR:Q9C0F0; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q9C0F0; protein.
DR Bgee; ENSG00000141431; Expressed in buccal mucosa cell and 138 other tissues.
DR ExpressionAtlas; Q9C0F0; baseline and differential.
DR Genevisible; Q9C0F0; HS.
DR GO; GO:0035517; C:PR-DUB complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042975; F:peroxisome proliferator activated receptor binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0051055; P:negative regulation of lipid biosynthetic process; IDA:CACAO.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR026905; ASX-like_PHD.
DR InterPro; IPR024811; ASX/ASX-like.
DR InterPro; IPR028020; ASX_DEUBAD_dom.
DR InterPro; IPR024818; ASXL3.
DR InterPro; IPR007759; Asxl_HARE-HTH.
DR InterPro; IPR044867; DEUBAD_dom.
DR PANTHER; PTHR13578; PTHR13578; 1.
DR PANTHER; PTHR13578:SF18; PTHR13578:SF18; 1.
DR Pfam; PF13919; ASXH; 1.
DR Pfam; PF05066; HARE-HTH; 1.
DR Pfam; PF13922; PHD_3; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51913; HTH_HARE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome;
KW Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..2248
FT /note="Putative Polycomb group protein ASXL3"
FT /id="PRO_0000320670"
FT DOMAIN 10..84
FT /note="HTH HARE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01261"
FT DOMAIN 254..363
FT /note="DEUBAD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01264"
FT ZN_FING 2210..2247
FT /note="PHD-type; atypical"
FT REGION 156..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1431..1462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1573..1596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1990..2068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..906
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..986
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1431..1452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2013..2051
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2053..2068
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 294..317
FT /note="MGSDGILRLSTSALNNEFFAYAAQ -> SRNEPFLQEAMVPISGGCHEIKMS
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042433"
FT VAR_SEQ 318..2248
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042434"
FT VARIANT 954
FT /note="N -> S (in dbSNP:rs2282632)"
FT /evidence="ECO:0000269|PubMed:11214970,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_039267"
FT VARIANT 1109..2248
FT /note="Missing (found in a patient with cohesinopathy;
FT unknown pathological significance)"
FT /evidence="ECO:0000269|PubMed:30158690"
FT /id="VAR_082310"
FT VARIANT 1415
FT /note="M -> R (in dbSNP:rs16964887)"
FT /id="VAR_039268"
FT VARIANT 1652
FT /note="V -> M (in dbSNP:rs17746949)"
FT /id="VAR_039269"
FT VARIANT 1708
FT /note="M -> V (in dbSNP:rs7232237)"
FT /evidence="ECO:0000269|PubMed:11214970,
FT ECO:0000269|PubMed:14702039"
FT /id="VAR_039270"
FT CONFLICT 46
FT /note="S -> RN (in Ref. 2; BAD18599)"
FT /evidence="ECO:0000305"
FT CONFLICT 49
FT /note="S -> P (in Ref. 2; BAD18599)"
FT /evidence="ECO:0000305"
FT CONFLICT 1079
FT /note="A -> V (in Ref. 5; CAB61377)"
FT /evidence="ECO:0000305"
FT CONFLICT 1632
FT /note="E -> K (in Ref. 2; BAB71186)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2248 AA; 241919 MW; E8BAC62B817F904D CRC64;
MKDKRKKKDR TWAEAARLAL EKHPNSPMTA KQILEVIQKE GLKETSGTSP LACLNAMLHT
NTRIGDGTFF KIPGKSGLYA LKKEESSCPA DGTLDLVCES ELDGTDMAEA NAHGEENGVC
SKQVTDEASS TRDSSLTNTA VQSKLVSSFQ QHTKKALKQA LRQQQKRRNG VSMMVNKTVP
RVVLTPLKVS DEQSDSPSGS ESKNGEADSS DKEMKHGQKS PTGKQTSQHL KRLKKSGLGH
LKWTKAEDID IETPGSILVN TNLRALINKH TFASLPQHFQ QYLLLLLPEV DRQMGSDGIL
RLSTSALNNE FFAYAAQGWK QRLAEGEFTP EMQLRIRQEI EKEKKTEPWK EKFFERFYGE
KLGMSREESV KLTTGPNNAG AQSSSSCGTS GLPVSAQTAL AEQQPKSMKS PASPEPGFCA
TLCPMVEIPP KDIMAELESE DILIPEESVI QEEIAEEVET SICECQDENH KTIPEFSEEA
ESLTNSHEEP QIAPPEDNLE SCVMMNDVLE TLPHIEVKIE GKSESPQEEM TVVIDQLEVC
DSLIPSTSSM THVSDTEHKE SETAVETSTP KIKTGSSSLE GQFPNEGIAI DMELQSDPEE
QLSENACISE TSFSSESPEG ACTSLPSPGG ETQSTSEESC TPASLETTFC SEVSSTENTD
KYNQRNSTDE NFHASLMSEI SPISTSPEIS EASLMSNLPL TSEASPVSNL PLTSETSPMS
DLPLTSETSS VSSMLLTSET TFVSSLPLPS ETSPISNSSI NERMAHQQRK SPSVSEEPLS
PQKDESSATA KPLGENLTSQ QKNLSNTPEP IIMSSSSIAP EAFPSEDLHN KTLSQQTCKS
HVDTEKPYPA SIPELASTEM IKVKNHSVLQ RTEKKVLPSP LELSVFSEGT DNKGNELPSA
KLQDKQYISS VDKAPFSEGS RNKTHKQGST QSRLETSHTS KSSEPSKSPD GIRNESRDSE
ISKRKTAEQH SFGICKEKRA RIEDDQSTRN ISSSSPPEKE QPPREEPRVP PLKIQLSKIG
PPFIIKSQPV SKPESRASTS TSVSGGRNTG ARTLADIKAR AQQARAQREA AAAAAVAAAA
SIVSGAMGSP GEGGKTRTLA HIKEQTKAKL FAKHQARAHL FQTSKETRLP PPLSSKEGPP
NLEVSSTPET KMEGSTGVII VNPNCRSPSN KSAHLRETTT VLQQSLNPSK LPETATDLSV
HSSDENIPVS HLSEKIVSST SSENSSVPML FNKNSVPVSV CSTAISGAIK EHPFVSSVDK
SSVLMSVDSA NTTISACNIS MLKTIQGTDT PCIAIIPKCI ESTPISATTE GSSISSSMDD
KQLLISSSSA SNLVSTQYTS VPTPSIGNNL PNLSTSSVLI PPMGINNRFP SEKIAIPGSE
EQATVSMGTT VRAALSCSDS VAVTDSLVAH PTVAMFTGNM LTINSYDSPP KLSAESLDKN
SGPRNRADNS GKPQQPPGGF APAAINRSIP CKVIVDHSTT LTSSLSLTVS VESSEASLDL
QGRPVRTEAS VQPVACPQVS VISRPEPVAN EGIDHSSTFI AASAAKQDSK TLPATCTSLR
ELPLVPDKLN EPTAPSHNFA EQARGPAPFK SEADTTCSNQ YNPSNRICWN DDGMRSTGQP
LVTHSGSSKQ KEYLEQSCPK AIKTEHANYL NVSELHPRNL VTNVALPVKS ELHEADKGFR
MDTEDFPGPE LPPPAAEGAS SVQQTQNMKA STSSPMEEAI SLATDALKRV PGAGSSGCRL
SSVEANNPLV TQLLQGNLPL EKVLPQPRLG AKLEINRLPL PLQTTSVGKT APERNVEIPP
SSPNPDGKGY LAGTLAPLQM RKRENHPKKR VARTVGEHTQ VKCEPGKLLV EPDVKGVPCV
ISSGISQLGH SQPFKQEWLN KHSMQNRIVH SPEVKQQKRL LPSCSFQQNL FHVDKNGGFH
TDAGTSHRQQ FYQMPVAARG PIPTAALLQA SSKTPVGCNA FAFNRHLEQK GLGEVSLSSA
PHQLRLANML SPNMPMKEGD EVGGTAHTMP NKALVHPPPP PPPPPPPPLA LPPPPPPPPP
LPPPLPNAEV PSDQKQPPVT METTKRLSWP QSTGICSNIK SEPLSFEEGL SSSCELGMKQ
VSYDQNEMKE QLKAFALKSA DFSSYLLSEP QKPFTQLAAQ KMQVQQQQQL CGNYPTIHFG
STSFKRAASA IEKSIGILGS GSNPATGLSG QNAQMPVQNF ADSSNADELE LKCSCRLKAM
IVCKGCGAFC HDDCIGPSKL CVACLVVR
