ASY2_ARATH
ID ASY2_ARATH Reviewed; 1399 AA.
AC F4JTJ9; O49370; Q0WNG7;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Meiosis-specific protein ASY2 {ECO:0000305};
DE AltName: Full=Protein ASYNAPTIC 2 {ECO:0000305};
GN Name=ASY2 {ECO:0000305};
GN OrderedLocusNames=At4g32200 {ECO:0000312|Araport:AT4G32200};
GN ORFNames=F10M6.160 {ECO:0000312|EMBL:CAA16970.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 922-1399.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for normal meiosis. {ECO:0000250|UniProtKB:F4HRV8}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:F4HRV8}.
CC Nucleus {ECO:0000250|UniProtKB:F4HRV8}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA16970.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79938.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL021811; CAA16970.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161580; CAB79938.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86019.1; -; Genomic_DNA.
DR EMBL; AK229474; BAF01332.1; -; mRNA.
DR PIR; T05408; T05408.
DR RefSeq; NP_194947.2; NM_119372.3.
DR AlphaFoldDB; F4JTJ9; -.
DR SMR; F4JTJ9; -.
DR STRING; 3702.AT4G32200.1; -.
DR iPTMnet; F4JTJ9; -.
DR PaxDb; F4JTJ9; -.
DR PRIDE; F4JTJ9; -.
DR ProteomicsDB; 246526; -.
DR EnsemblPlants; AT4G32200.1; AT4G32200.1; AT4G32200.
DR GeneID; 829353; -.
DR Gramene; AT4G32200.1; AT4G32200.1; AT4G32200.
DR KEGG; ath:AT4G32200; -.
DR Araport; AT4G32200; -.
DR TAIR; locus:2116510; AT4G32200.
DR eggNOG; KOG4652; Eukaryota.
DR HOGENOM; CLU_254442_0_0_1; -.
DR InParanoid; F4JTJ9; -.
DR OrthoDB; 1329508at2759; -.
DR PRO; PR:F4JTJ9; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JTJ9; baseline and differential.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007130; P:synaptonemal complex assembly; TAS:TAIR.
DR Gene3D; 3.30.900.10; -; 1.
DR InterPro; IPR003511; HORMA_dom.
DR InterPro; IPR036570; HORMA_dom_sf.
DR Pfam; PF02301; HORMA; 1.
DR SUPFAM; SSF56019; SSF56019; 1.
DR PROSITE; PS50815; HORMA; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Coiled coil; Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..1399
FT /note="Meiosis-specific protein ASY2"
FT /id="PRO_0000438697"
FT DOMAIN 10..248
FT /note="HORMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00109"
FT REGION 257..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1205..1246
FT /evidence="ECO:0000255"
FT COMPBIAS 265..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..519
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..651
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1071
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1399 AA; 158526 MW; 9944F51385765A54 CRC64;
MVVVSKNNEQ QSLILTTELL RTAIFNISYI RGLFPVRYFK DMSVPALDLK MKKLMPMDAE
SRRLIGWMEK GVYDALHKKH LKKLIFYICE TVDGPLIEEY IFSFSYSDSD SQDVRMNINI
TGINTYGGTL NSTADNSTAD MTLNQMSSVD EDFGQNARRS NAFVTYQRFS VYISFHIANY
RLCYFFASVQ RTILMKLLYY EYVPPDYQPP FFRGCSEEEE AQYVWPKIPL RMEIGNVNSQ
HHVLTVKVKS VLDPYDPCED ENDNMQDDER SKGPDSLHDD QPCKVFTKPS KLILTENKDA
DHGEVNEEKL LLITPICEIL QDVKQDQVEH QLAKVKDTKG RPASIVQNPI LQSHEYDIRR
LKARLQRLER HISVPDSPQE GIRKWFAAVS SQLFYKVMEA CTRRKPILGD AILSSTVKVQ
NFNAKICSKL LKKPASIYRK KHFTLNSASL RISGLAGSIF AWAVGFCLFS AQIGHVFVQP
KTRSSESKPK VTMEELEEKL TPPSSEPKSA PPSSEPKSAP PSSEPLEKLA VIRRILPEIF
AQRCGQRNSS FEAFAQRRTT YDYYNIRLNP REIIFRRLQE ESKVALALSS ANYFVLSILY
RFFRQWSEVS LVRRNSRLTG NPSNEAQSSR SNRIEIPTLL DEPDREGSGG HLAAPEDPVD
FLAQFDPLID LEDAYNTQPQ YTEAEVNARL LHEDHVEFDL VPVVSWNTEI TAKKTLSTTE
SVAEVFALCG SGDRPLTCMI PGENERPWNP PRGYVCMYEA YFRQCHLWFP IPSLIISFLN
RRHMAFSQLT PAAICNFVAA LTFGAEEGYL VNVRCFEEMT TLKAIRSPGY WVVNNRPKHN
FLPGPKVSNF KNWEEYYFYV RVDLESYERP FSGRKRMWTE FPDRYRPSPD FPVEFEGVLE
AIFRARRRTW KDVTRSRVNR IMGKVRKSFI SFAAGLLNMP PPPAPIEEER QPLDGEAAAS
NPPVSAGPSG VDQVSHEMVN PESQDRMCLE GADVVPAQEI AECDRSQSVQ VVEPEVQNIT
DDRSVVVYAA PPAGEEVNTG LTILDQDKDE TVAEPGISRR SREEKGKGGA NQSKKRSASE
AGLDEAAAPK TFRLSRGETL NSDQFTFKYS GEKFLVRDQE AASHLWRNLM LPGTKDFPNP
DDLVLKEGYQ KFARSSLETA ALANDLIATY DRKLKLKLAD REAFDNLKKC ADQAKAIYAK
DMKEMASLRD AAEIHKAEMS SLNDEVKRLN SREADLQKEF SDLQVALVAV KEHGERECNR
LRNDRAAKVA RTTKKAQARL DRVKAYLKEQ EDLVGPKVDA ENQARGAEEI VGILMQRGAK
IAASELSGLK ELTKRATDEV NALNVIELGD DDLNMSPDQL GFSRQISQVA PVADQHGSNV
DLLAEVIRRV SVEETNQTT
