ID   PLS_HALLA               Reviewed;          84 AA.
AC   P82595;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2001, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Perlustrin;
OS   Haliotis laevigata (Smooth Australian abalone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Vetigastropoda; Lepetellida; Haliotoidea; Haliotidae; Haliotis.
OX   NCBI_TaxID=36097;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RC   TISSUE=Shell;
RX   PubMed=11444832; DOI=10.1006/bbrc.2001.5170;
RA   Weiss I.M., Goehring W., Fritz M., Mann K.;
RT   "Perlustrin, a Haliotis laevigata (abalone) nacre protein, is homologous to
RT   the insulin-like growth factor binding protein N-terminal module of
RT   vertebrates.";
RL   Biochem. Biophys. Res. Commun. 285:244-249(2001).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-33.
RC   TISSUE=Shell;
RX   PubMed=10623567; DOI=10.1006/bbrc.1999.1907;
RA   Weiss I.M., Kaufmann S., Mann K., Fritz M.;
RT   "Purification and characterization of perlucin and perlustrin, two new
RT   proteins from the shell of the mollusc Haliotis laevigata.";
RL   Biochem. Biophys. Res. Commun. 267:17-21(2000).
CC   -!- FUNCTION: Binds human IGF-I and IGF-II and bovine insulin.
CC   -!- TISSUE SPECIFICITY: Shell.
CC   -!- MASS SPECTROMETRY: Mass=9325.8; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:11444832};
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DR   AlphaFoldDB; P82595; -.
DR   SMR; P82595; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR000867; IGFBP-like.
DR   InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR   Pfam; PF00219; IGFBP; 1.
DR   SMART; SM00121; IB; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00222; IGFBP_N_1; 1.
DR   PROSITE; PS51323; IGFBP_N_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Growth factor binding.
FT   CHAIN           1..84
FT                   /note="Perlustrin"
FT                   /id="PRO_0000152777"
FT   DOMAIN          1..82
FT                   /note="IGFBP N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
SQ   SEQUENCE   84 AA;  9338 MW;  42B47741B9101A5B CRC64;
     LSCASCENAA CPAIGLPCKP SEYVYTPCGC CPQCPLELGQ PCGSFTQRCQ FDLWCLRRKG
     NKIEAYKYVP WHLDFKGVCA RVDV