ID   PLS_STAAW               Reviewed;        1371 AA.
AC   Q8NUV0;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Putative surface protein MW2416;
DE   Flags: Precursor;
GN   OrderedLocusNames=MW2416;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}.
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DR   EMBL; BA000033; BAB96281.1; -; Genomic_DNA.
DR   RefSeq; WP_001205102.1; NC_003923.1.
DR   AlphaFoldDB; Q8NUV0; -.
DR   SMR; Q8NUV0; -.
DR   EnsemblBacteria; BAB96281; BAB96281; BAB96281.
DR   KEGG; sam:MW2416; -.
DR   HOGENOM; CLU_000977_4_1_9; -.
DR   OMA; IWEANIS; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   InterPro; IPR011098; G5_dom.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR031477; SasG_E.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   Pfam; PF07501; G5; 7.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   Pfam; PF17041; SasG_E; 6.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   SMART; SM01208; G5; 7.
DR   TIGRFAMs; TIGR01168; YSIRK_signal; 1.
DR   PROSITE; PS51109; G5; 7.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE   3: Inferred from homology;
KW   Cell wall; Peptidoglycan-anchor; Repeat; Secreted; Signal.
FT   SIGNAL          1..50
FT                   /evidence="ECO:0000255"
FT   CHAIN           51..1342
FT                   /note="Putative surface protein MW2416"
FT                   /id="PRO_0000005637"
FT   PROPEP          1343..1371
FT                   /note="Removed by sortase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT                   /id="PRO_0000005638"
FT   DOMAIN          419..501
FT                   /note="G5 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT   DOMAIN          547..629
FT                   /note="G5 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT   DOMAIN          675..757
FT                   /note="G5 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT   DOMAIN          803..885
FT                   /note="G5 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT   DOMAIN          931..1013
FT                   /note="G5 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT   DOMAIN          1059..1141
FT                   /note="G5 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT   DOMAIN          1187..1269
FT                   /note="G5 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT   REGION          76..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          446..485
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          502..746
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          758..1002
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1014..1348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           1339..1343
FT                   /note="LPXTG sorting signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   COMPBIAS        92..121
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        457..471
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        535..550
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        560..584
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        585..599
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        617..635
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        663..678
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        688..712
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        713..727
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        791..806
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        816..840
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        841..855
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        873..891
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        919..934
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        944..968
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        969..983
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1047..1062
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1072..1096
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1097..1111
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1129..1147
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1175..1190
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1200..1224
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1225..1239
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1257..1281
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1301..1342
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1342
FT                   /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
SQ   SEQUENCE   1371 AA;  150028 MW;  F220E331DAE08E73 CRC64;
     MRDKKGPVNK RVDFLSNKLN KYSIRKFTVG TASILIGSLM YLGTQQEAEA AENNIENPTT
     LKDNVQSKEV KIEEVTNKDT APQGVEAKSE VTSNKDTIEH EPSVKAEDIS KKEDTPKEVA
     DVAEVQPKSS VTHNAETPKV RKARSVDEGS FDITRDSKNV VESTPITIQG KEHFEGYGSV
     DIQSNPEDLK VSEVTRFNNK SIGKNELTGA LQLKNKVSFK NDFEFNIRVA NNHQSVTTGA
     DGWGFLFSKG DGNEYLQKGG ILGPKGMENS AGFKIDTGYN FKDPMDKEEK QAGQGFKGYG
     TFVKTGADGT TAKVGTNIPT RGKADNSFQY ADNSIDTTDG KFHGQLLNNL KLAYNEKSGI
     MRAEYAGKIW EANISDLGLD KSEAYNFLIT SSQRQGTSQG VYANGWMRTD LNNSTFKLTP
     NLVNKTETKT VEIPFETKRE FNPKLQPGEE RVKQEGQPGS KTITTPITVN PLTGEKVGEG
     QPTEEITKQP VDKIVEFGGE KIPQGHKDIF DPNLPTDQTE KVPGKPGIKN PDTGKVIEEP
     VDDVIKHGPK TGTPETKTVE IPFETKREFN PKLQPGEERV KQEGQPGSKT ITTPITVNPL
     TGEKVGEGQP TEEITKQPVD KIVEFGGEKI PQGHKDIFDP NLPTDQTEKV PGKPGIKNPD
     TGKVIEEPVD DVIKHGPKTG TPETKTVEIP FETKREFNPK LQPGEERVKQ EGQPGSKTIT
     TPITVNPLTG EKVGEGQPTE EITKQPIDKI VEFGGEKIPQ GHKDIFDPNL PTDQTEKVPG
     KPGIKNPDTG KVIEEPVDDV IKHGPKTGTP ETKTVEIPFE TKREFNPKLQ PGEERVKQEG
     QPGSKTITTP ITVNPLTGEK VGEGQPTEEI TKQPVDKIVE FGGEKIPQGH KDIFDPNLPT
     DQTEKVPGKP GIKNPDTGKV IEEPVDDVIK HGPKTGTPET KTVEIPFETK REFNPKLQPG
     EERVKQEGQP GSKTITTPIT VNPLTGEKVG EGQPTEEITK QPIDKIVEFG GEKIPQGHKD
     IFDPNLPTDQ TEKVPGKPGI KNPDTGKVIE EPVDDVIKHG PKTGTPETKT VEIPFETKRE
     FNPKLQPGEE RVKQEGQPGS KTITTPITVN PLTGEKVGEG QPTEEITKQP VDKIVEFGGE
     KIPQGHKDIF DPNLPTDQTE KVPGKPGIKN PDTGKVIEEP VDDVIKHGPK TGTPETKTVE
     IPFETKREFN PKLQPGEERV KQEGQPGSKT ITTPITVNPL TGEKVGEGQP TEEITKQPVD
     KIVEFGGEKP KDPKGPENPE KPSRPTHPSG PVNPDNPGLS KDRAKPNEPV HSMDKNDKVK
     KSKIAKKSVA NQEKKRAELP KTGAESTQKG LIFSSIIGIA GLMLLARRRK N