PLS_STAES
ID PLS_STAES Reviewed; 1469 AA.
AC Q8CQD9;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Accumulation-associated protein;
DE Flags: Precursor;
GN OrderedLocusNames=SE_0175;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC ProRule:PRU00477}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE015929; AAO03772.1; -; Genomic_DNA.
DR RefSeq; NP_763730.1; NC_004461.1.
DR AlphaFoldDB; Q8CQD9; -.
DR SMR; Q8CQD9; -.
DR STRING; 176280.SE_0175; -.
DR EnsemblBacteria; AAO03772; AAO03772; SE_0175.
DR KEGG; sep:SE_0175; -.
DR PATRIC; fig|176280.10.peg.160; -.
DR eggNOG; COG3087; Bacteria.
DR eggNOG; COG3583; Bacteria.
DR eggNOG; COG4932; Bacteria.
DR HOGENOM; CLU_000977_4_1_9; -.
DR OMA; IWEANIS; -.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR InterPro; IPR011098; G5_dom.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR031477; SasG_E.
DR InterPro; IPR005877; YSIRK_signal_dom.
DR Pfam; PF07501; G5; 7.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF17041; SasG_E; 6.
DR Pfam; PF04650; YSIRK_signal; 1.
DR SMART; SM01208; G5; 7.
DR TIGRFAMs; TIGR01168; YSIRK_signal; 1.
DR PROSITE; PS51109; G5; 7.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE 3: Inferred from homology;
KW Cell wall; Peptidoglycan-anchor; Repeat; Secreted; Signal.
FT SIGNAL 1..52
FT /evidence="ECO:0000255"
FT CHAIN 53..1435
FT /note="Accumulation-associated protein"
FT /id="PRO_0000005641"
FT PROPEP 1436..1469
FT /note="Removed by sortase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT /id="PRO_0000005642"
FT DOMAIN 446..528
FT /note="G5 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT DOMAIN 574..656
FT /note="G5 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT DOMAIN 702..784
FT /note="G5 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT DOMAIN 830..912
FT /note="G5 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT DOMAIN 958..1040
FT /note="G5 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT DOMAIN 1086..1168
FT /note="G5 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT DOMAIN 1211..1296
FT /note="G5 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT REGION 52..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..1443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 1432..1436
FT /note="LPXTG sorting signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT COMPBIAS 59..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..798
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..883
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..926
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..984
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1052
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1125..1139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1304..1405
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1411..1443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1435
FT /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
SQ SEQUENCE 1469 AA; 157138 MW; 9D9333095E680182 CRC64;
MGKRRQGPIN KKVDFLPNKL NKYSIRKFTV GTASILLGST LIFGSSSHEA KAAEEKQVDP
ITQANQNDSS ERSLENTNQP TVNNEAPQMS STLQAEEGSN AEAPNVPTIK ANSDNDTQTQ
FSEAPTRNDL ARKEDIPAVS KNEELQSSQP NTDSKIEPTT SEPVNLNYSS PFMSLLSMPA
DSSSNNTKNT IDIPPTTVKG RDNYDFYGRV DIQSNPTDLN ATNLTRYNYG QPPGTTTAGA
VQFKNQVSFD KDFDFNIRVA NNRQSNTTGA DGWGFMFSKK DGDDFLKNGG ILREKGTPSA
AGFRIDTGYY NNDPLDKIQK QAGQGYRGYG TFVKNDSQGN TSKVGSGTPS TDFLNYADNT
TNDLDGKFHG QKLNNVNLKY NASNQTFTAT YAGKTWTATL SELGLSPTDS YNFLVTSSQY
GNGNSGTYAD GVMRADLDGA TLTYTPKAVD GDPITSTKEI PFNKKREFDP NLAPGTEKVV
QKGEPGIETT TTPTYVNPNT GEKVGEGTPT TKITKQPVDE IVHYGGEEIK PGHKDEFDPN
APKGSQTTQP GKPGVKNPDT GEVVTPPVDD VTKYGPVDGD PITSTEEIPF DKKREFNPDL
KPGEERVKQK GEPGTKTITT PTTKNPLTGE KVGEGEPTEK ITKQPVDEIT EYGGEEIKPG
HKDEFDPNAP KGSQEDVPGK PGVKNPDTGE VVTPPVDDVT KYGPVDGDPI TSTEEIPFDK
KREFDPNLAP GTEKVVQKGE PGTKTITTPT TKNPLTGEKV GEGEPTEKIT KQPVDEIVHY
GGEEIKPGHK DEFDPNAPKG SQEDVPGKPG VKNPDTGEVV TPPVDDVTKY GPVDGDPITS
TEEIPFDKKR EFNPDLKPGE ERVKQKGEPG TKTITTPTTK NPLTGEKVGE GEPTEKVTKQ
PVDEIVHYGG EEIKPGHKDE FDPNAPKGSQ EDVPGKPGVK NPDTGEVVTP PVDDVTKYGP
VDGDPITSTE EIPFDKKREF DPNLAPGTEK VVQKGEPGTK TITTPTTKNP LTGEKVGEGE
PTEKITKQPV DEIVHYGGEE IKPGHKDEFD PNAPKGSQTT QPGKPGVKNP DTGEVVTPPV
DDVTKYGPVD GDPITSTEEI PFDKKREFDP NLAPGTEKVV QKGEPGTKTI TTPTTKNPLT
GEKVGEGEPT EKITKQPVDE IVHYGGEQIP QGHKDEFDPN APVDSKTEVP GKPGVKNPDT
GEVVTPPVDD VTKYGPKVGN PITSTEEIPF DKKRVFNPDL KPGEERVKQK GEPGTKTITT
PILVNPITGE KVGEGKSTEK VTKQPVDEIV EYGPTKAEPG KPAEPGKPAE PGKPAEPGKP
AEPGTPAEPG KPAEPGKPAE PGKPAEPGKP AEPGKPAEPG TPAEPGKPAE PGKPAEPGKP
AEPGTPAEPG KPAEPGTPAE PGKPAEPGTP TQSGAPEQPN RSMHSTDNKN QLPDTGENRQ
ANEGTLVGSL LAIVGSLFIF GRRKKGNEK
