ID   PLX1_PHYSA              Reviewed;          64 AA.
AC   Q5DVA6;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Phylloxin-S1 {ECO:0000303|PubMed:18644413};
DE            Short=PLX-S1 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=Phylloxin {ECO:0000303|PubMed:15927704};
DE   Flags: Precursor;
GN   Name=PLX-S {ECO:0000303|PubMed:15927704};
OS   Phyllomedusa sauvagei (Sauvage's leaf frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phyllomedusa.
OX   NCBI_TaxID=8395;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 45-63, MASS SPECTROMETRY,
RP   AMIDATION AT GLN-63, AND SUBCELLULAR LOCATION.
RC   TISSUE=Skin secretion;
RX   PubMed=15927704; DOI=10.1016/j.regpep.2005.01.017;
RA   Chen T., Walker B., Zhou M., Shaw C.;
RT   "Dermatoxin and phylloxin from the waxy monkey frog, Phyllomedusa sauvagei:
RT   cloning of precursor cDNAs and structural characterization from lyophilized
RT   skin secretion.";
RL   Regul. Pept. 129:103-108(2005).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Antimicrobial peptide against both Gram-positive and Gram-
CC       negative bacteria. {ECO:0000250|UniProtKB:P81565}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15927704}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:15927704}.
CC   -!- MASS SPECTROMETRY: Mass=1967.56; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:15927704};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Phylloxin subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=00901";
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DR   EMBL; AJ865344; CAI26287.1; -; mRNA.
DR   AlphaFoldDB; Q5DVA6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   InterPro; IPR016322; FSAP.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
DR   PIRSF; PIRSF001822; Dermaseptin_precursor; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Cleavage on pair of basic residues; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..44
FT                   /evidence="ECO:0000305|PubMed:15927704"
FT                   /id="PRO_0000449667"
FT   PEPTIDE         45..63
FT                   /note="Phylloxin-S1"
FT                   /evidence="ECO:0000269|PubMed:15927704"
FT                   /id="PRO_5004254946"
FT   MOD_RES         63
FT                   /note="Glutamine amide"
FT                   /evidence="ECO:0000269|PubMed:15927704"
SQ   SEQUENCE   64 AA;  7153 MW;  40DE6AF603BFA606 CRC64;
     MVFLKKSLLL VLFVGLVSLS ICEENKREEH EEVEENAEKA EEKRGWMSKI ASGIGTFLSG
     VQQG