PM2P5_HUMAN
ID PM2P5_HUMAN Reviewed; 134 AA.
AC A8MQ11;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Postmeiotic segregation increased 2-like protein 5;
DE AltName: Full=Postmeiotic segregation increased protein 4;
DE AltName: Full=Postmeiotic segregation increased protein 7;
DE AltName: Full=Putative postmeiotic segregation increased 2 pseudogene 5;
GN Name=PMS2P5; Synonyms=PMS2L5, PMS4, PMS7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Duodenum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP GENE FAMILY.
RX PubMed=7980603; DOI=10.1006/bbrc.1994.2598;
RA Horii A., Han H.J., Sasaki S., Shimada M., Nakamura Y.;
RT "Cloning, characterization and chromosomal assignment of the human genes
RT homologous to yeast PMS1, a member of mismatch repair genes.";
RL Biochem. Biophys. Res. Commun. 204:1257-1264(1994).
CC -!- MISCELLANEOUS: Encoded by one of the numerous copies of postmeiotic
CC segregation increased 2-like genes scattered in the q11-q22 region of
CC the chromosome 7.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC004166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027480; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; A8MQ11; -.
DR SMR; A8MQ11; -.
DR BioMuta; HGNC:9130; -.
DR jPOST; A8MQ11; -.
DR MassIVE; A8MQ11; -.
DR PeptideAtlas; A8MQ11; -.
DR PRIDE; A8MQ11; -.
DR GeneCards; PMS2P5; -.
DR HGNC; HGNC:9130; PMS2P5.
DR neXtProt; NX_A8MQ11; -.
DR PhylomeDB; A8MQ11; -.
DR PathwayCommons; A8MQ11; -.
DR SignaLink; A8MQ11; -.
DR ChiTaRS; PMS2P5; human.
DR Pharos; A8MQ11; Tdark.
DR PRO; PR:A8MQ11; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A8MQ11; protein.
DR GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR GO; GO:0032389; C:MutLalpha complex; IBA:GO_Central.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR GO; GO:0016446; P:somatic hypermutation of immunoglobulin genes; IBA:GO_Central.
DR Gene3D; 3.30.565.10; -; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR PANTHER; PTHR10073; PTHR10073; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
PE 5: Uncertain;
KW Reference proteome.
FT CHAIN 1..134
FT /note="Postmeiotic segregation increased 2-like protein 5"
FT /id="PRO_0000334619"
SQ SEQUENCE 134 AA; 15170 MW; 49EF58AE55410491 CRC64;
MWGRRRKLRR LNDVTISTCH VSAKVGTRLV FDHDGKIIQK TPYPHPRGTT VSVKQLFSTL
PVRHKEFQRN IKKKRACFPF AFCRDCQFLE GSPAMLPVQP AKLTPRSTPP HPCSLEDNVI
TVFSSVKNGP GSSR
