PMA6E_HUMAN
ID PMA6E_HUMAN Reviewed; 647 AA.
AC A0A0J9YXQ4;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2015, sequence version 1.
DT 03-AUG-2022, entry version 35.
DE RecName: Full=Paraneoplastic antigen Ma6E {ECO:0000312|HGNC:HGNC:50767};
GN Name=PNMA6E {ECO:0000312|HGNC:HGNC:50767};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
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DR EMBL; BX469942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U82695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0J9YXQ4; -.
DR SMR; A0A0J9YXQ4; -.
DR BioMuta; PNMA6E; -.
DR MassIVE; A0A0J9YXQ4; -.
DR PeptideAtlas; A0A0J9YXQ4; -.
DR Ensembl; ENST00000445091.3; ENSP00000488500.1; ENSG00000214897.5.
DR MANE-Select; ENST00000445091.3; ENSP00000488500.1; NM_001367770.1; NP_001354699.1.
DR GeneCards; PNMA6E; -.
DR HGNC; HGNC:50767; PNMA6E.
DR HPA; ENSG00000214897; Tissue enhanced (epididymis, ovary, testis).
DR neXtProt; NX_A0A0J9YXQ4; -.
DR OpenTargets; ENSG00000214897; -.
DR VEuPathDB; HostDB:ENSG00000214897; -.
DR GeneTree; ENSGT01030000234522; -.
DR OMA; THANDML; -.
DR SignaLink; A0A0J9YXQ4; -.
DR Pharos; A0A0J9YXQ4; Tdark.
DR PRO; PR:A0A0J9YXQ4; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; A0A0J9YXQ4; protein.
DR Bgee; ENSG00000214897; Expressed in right testis and 13 other tissues.
DR ExpressionAtlas; A0A0J9YXQ4; baseline and differential.
DR InterPro; IPR026523; PNMA.
DR PANTHER; PTHR23095; PTHR23095; 2.
DR Pfam; PF14893; PNMA; 2.
PE 4: Predicted;
KW Reference proteome.
FT CHAIN 1..647
FT /note="Paraneoplastic antigen Ma6E"
FT /id="PRO_0000440654"
FT REGION 111..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 647 AA; 65155 MW; ADF7E0232F9CA1BA CRC64;
MALAMLRDWC RWMGANAERS LLILGIPDDC KEHEFQEAVR AALSPLGRYR VLTKHFRKEL
GAKAALVEFA EYLNRSLIPH QIPGNGGPWK VIFLPQVPVI EFQDMPSFPA QPQGQAVAKA
AGEGGGAGEA GGVGEVGAAG EAGGTGEAGA TGEAGAAGEA GGAGEAGGVG EAGAAGEAGG
AGEAGAAGEG GAAGEAGGAG EAGGVGEAGA AGEAGGAGEA GGVGEAGAAG EAGGAGEAGA
AGEAGGAGEG RAAGEAGAAG EAGAVGEAGA AGEAGAVGEA GAAGEAGAVG EAGGTNVTKA
WVQPWRCTLQ PVLENRAYRE LRPFSRREQP GCEEESFESW VEHAKDMLQL WCHASEREKK
RWLLESLGGP ALEVVSGLLE EDTNLSALDC LAALGQVFRN QDTRMTSRLK FLTCTQGPQE
GLFAFVVRLE GLLQRAVEKG AVCPALANYL RLQQVLSWAR PSEALQDTLR GMQLEKRPPG
FLGLLRLIRE MEAWAAFPAR SQQGVAWAAA PVESEDPAAA QASPAQGNAS EAGPGAEDAA
EAASATKEAA RGAPAAGEGE SAPAGPEGLG QARPIEVPWG SSPARMSSAV WVFPRGLSWG
PEGLIQVRGQ EARKPPLEGL QTILEEPENE DEDGAGDEGQ PKSSQGK
