ID   PMCH_RAT                Reviewed;          64 AA.
AC   P80250;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Palmitoyl-CoA hydrolase;
DE            EC=3.1.2.2;
DE   AltName: Full=Long-chain fatty-acyl-CoA hydrolase;
DE   Flags: Fragment;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Liver;
RX   PubMed=8100522; DOI=10.1111/j.1432-1033.1993.tb17973.x;
RA   Alexson S.E.H., Mentlein R., Wernstedt C., Hellman U.;
RT   "Isolation and characterization of microsomal acyl-CoA thioesterase. A
RT   member of the rat liver microsomal carboxylesterase multi-gene family.";
RL   Eur. J. Biochem. 214:719-727(1993).
CC   -!- FUNCTION: Hydrolysis of a variety of CoA thioesters of long-chain fatty
CC       acids.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate;
CC         Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2;
CC   -!- SUBUNIT: Monomer and homotrimer.
CC   -!- SUBCELLULAR LOCATION: Microsome. Endoplasmic reticulum.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P80250; -.
DR   SMR; P80250; -.
DR   ESTHER; ratno-q68g49; Carb_B_Chordata.
DR   BRENDA; 3.1.2.2; 5301.
DR   BRENDA; 3.1.2.20; 5301.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0102991; F:myristoyl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016290; F:palmitoyl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Endoplasmic reticulum; Fatty acid metabolism;
KW   Hydrolase; Lipid metabolism; Microsome; Reference proteome.
FT   CHAIN           1..>64
FT                   /note="Palmitoyl-CoA hydrolase"
FT                   /id="PRO_0000070294"
FT   NON_TER         64
SQ   SEQUENCE   64 AA;  6919 MW;  E9FA5D7CD7870559 CRC64;
     NPSSPPVVDT TNTTSYPPMC SQDAVGGQVL ENIPLQEDCL YNFNTVPYIV GIIPEDIIPV
     AIEK