PMD2_ARATH
ID PMD2_ARATH Reviewed; 323 AA.
AC Q9SHJ6; A6XH03;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Peroxisomal and mitochondrial division factor 2 {ECO:0000303|PubMed:22147290};
DE AltName: Full=Ubiquitin-interacting factor 7 {ECO:0000303|Ref.3};
GN Name=PMD2 {ECO:0000303|PubMed:22147290}; Synonyms=UBI7 {ECO:0000303|Ref.3};
GN OrderedLocusNames=At1g06530 {ECO:0000312|Araport:AT1G06530};
GN ORFNames=F12K11.14 {ECO:0000312|EMBL:AAF24824.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 75-200.
RA Fu H.;
RT "Functional differentiation of ubiquitin-interacting factors from
RT Arabidopsis.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [5]
RP FUNCTION, SUBUNIT, INTERACTION WITH PMD1, AND SUBCELLULAR LOCATION.
RX PubMed=22147290; DOI=10.1105/tpc.111.090142;
RA Aung K., Hu J.;
RT "The Arabidopsis tail-anchored protein PEROXISOMAL AND MITOCHONDRIAL
RT DIVISION FACTOR1 is involved in the morphogenesis and proliferation of
RT peroxisomes and mitochondria.";
RL Plant Cell 23:4446-4461(2011).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=21896887; DOI=10.1104/pp.111.183160;
RA Duncan O., Taylor N.L., Carrie C., Eubel H., Kubiszewski-Jakubiak S.,
RA Zhang B., Narsai R., Millar A.H., Whelan J.;
RT "Multiple lines of evidence localize signaling, morphology, and lipid
RT biosynthesis machinery to the mitochondrial outer membrane of
RT Arabidopsis.";
RL Plant Physiol. 157:1093-1113(2011).
CC -!- FUNCTION: Involved in morphogenesis and proliferation of mitochondria.
CC Does not act redundantly with PMD1. Is not involved in peroxisomal
CC proliferation. {ECO:0000269|PubMed:22147290}.
CC -!- SUBUNIT: Homodimer. Interacts with PMD1. {ECO:0000269|PubMed:22147290}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000269|PubMed:21896887, ECO:0000269|PubMed:22147290}; Single-pass
CC membrane protein {ECO:0000255}.
CC -!- MISCELLANEOUS: Plant cells silencing PMD2 show enlarged mitochondria.
CC {ECO:0000269|PubMed:22147290}.
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DR EMBL; AC007592; AAF24824.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28002.1; -; Genomic_DNA.
DR EMBL; DQ785480; ABH03547.1; -; mRNA.
DR RefSeq; NP_172140.1; NM_100532.3.
DR AlphaFoldDB; Q9SHJ6; -.
DR SMR; Q9SHJ6; -.
DR STRING; 3702.AT1G06530.1; -.
DR iPTMnet; Q9SHJ6; -.
DR PaxDb; Q9SHJ6; -.
DR PRIDE; Q9SHJ6; -.
DR ProteomicsDB; 234688; -.
DR EnsemblPlants; AT1G06530.1; AT1G06530.1; AT1G06530.
DR GeneID; 837164; -.
DR Gramene; AT1G06530.1; AT1G06530.1; AT1G06530.
DR KEGG; ath:AT1G06530; -.
DR Araport; AT1G06530; -.
DR TAIR; locus:2009215; AT1G06530.
DR eggNOG; ENOG502RY0Y; Eukaryota.
DR HOGENOM; CLU_074678_0_0_1; -.
DR InParanoid; Q9SHJ6; -.
DR OMA; FYDADQT; -.
DR OrthoDB; 1532887at2759; -.
DR PhylomeDB; Q9SHJ6; -.
DR PRO; PR:Q9SHJ6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SHJ6; differential.
DR Genevisible; Q9SHJ6; AT.
DR GO; GO:0005576; C:extracellular region; HDA:TAIR.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; IDA:TAIR.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0007005; P:mitochondrion organization; IMP:TAIR.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..323
FT /note="Peroxisomal and mitochondrial division factor 2"
FT /id="PRO_0000432896"
FT TOPO_DOM 1..297
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9LXR8"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..323
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:Q9LXR8"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 73..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 28..278
FT /evidence="ECO:0000255"
SQ SEQUENCE 323 AA; 36119 MW; 8E956C7B9985E077 CRC64;
MAEERSLNGE ATGQDDESFF DSDQQGDDGK STELNQKIGD LESQNQELAR DNDAINRKIE
SLTAEIEELR GAESKAKRKM GEMEREIDKS DEERKVLEAI ASRASELETE VARLQHELIT
ARTEGEEATA EAEKLRSEIS QKGGGIEELE KEVAGLRTVK EENEKRMKEL ESKLGALEVK
ELDEKNKKFR AEEEMREKID NKEKEVHDLK EKIKSLESDV AKGKTELQKW ITEKMVVEDS
LKDSEKKVVA LESEIVELQK QLDDAEKMIN GLKNVVEEPL NGIEFKSWSP NVTAVGSGGA
VAAVAVAVAG AAVVCYIYHS RRV
