ID   PMF1_BOVIN              Reviewed;         205 AA.
AC   Q2T9N4;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Polyamine-modulated factor 1;
DE            Short=PMF-1;
GN   Name=PMF1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the MIS12 complex which is required for normal
CC       chromosome alignment and segregation and kinetochore formation during
CC       mitosis. May act as a cotranscription partner of NFE2L2 involved in
CC       regulation of polyamine-induced transcription of SSAT (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the MIS12 complex composed of MIS12, DSN1, NSL1
CC       and PMF1. Interacts with COPS7A. Interacts via its coiled-coil domain
CC       with the leucine-zipper domain of NFE2L2. The interaction with NFE2L2
CC       is required for the transcriptional regulation of SSAT (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with the kinetochore.
CC       {ECO:0000250}.
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DR   EMBL; BC111342; AAI11343.1; -; mRNA.
DR   RefSeq; NP_001033301.1; NM_001038212.2.
DR   AlphaFoldDB; Q2T9N4; -.
DR   SMR; Q2T9N4; -.
DR   STRING; 9913.ENSBTAP00000012411; -.
DR   PaxDb; Q2T9N4; -.
DR   PRIDE; Q2T9N4; -.
DR   Ensembl; ENSBTAT00000012411; ENSBTAP00000012411; ENSBTAG00000009432.
DR   GeneID; 616311; -.
DR   KEGG; bta:616311; -.
DR   CTD; 11243; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009432; -.
DR   eggNOG; ENOG502S3AR; Eukaryota.
DR   GeneTree; ENSGT00940000164230; -.
DR   HOGENOM; CLU_106985_1_1_1; -.
DR   InParanoid; Q2T9N4; -.
DR   OMA; IHLAHLM; -.
DR   OrthoDB; 1614035at2759; -.
DR   TreeFam; TF333180; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000009432; Expressed in neutrophil and 108 other tissues.
DR   GO; GO:0000444; C:MIS12/MIND type complex; ISS:UniProtKB.
DR   GO; GO:0000818; C:nuclear MIS12/MIND complex; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR   InterPro; IPR007128; PMF1/Nnf1.
DR   PANTHER; PTHR15459; PTHR15459; 1.
DR   Pfam; PF03980; Nnf1; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cell cycle; Cell division; Centromere; Chromosome;
KW   Chromosome partition; Coiled coil; Kinetochore; Mitosis; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..205
FT                   /note="Polyamine-modulated factor 1"
FT                   /id="PRO_0000283824"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          140..190
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   205 AA;  23416 MW;  D9830A6E586D5583 CRC64;
     MAEASSVNVG SGCAEKGPEE LSQEPARPGT NISRVKLFDT MVDTFLQKLV AAGSFQRFTD
     CYKRFYQLQP EMTQRIYDKF VTQLQTSIQE EISEIKAEGN LEAVLIALDA IVEESKDRKE
     QAWRPSGIPE KDLRSAMAPY LLQQRDALQR RVQRQEAENR QLADAVLAGR RQLEELQLQA
     QARQQAWQAL HREQKELLAV LKEPE