ID   PMIS2_HUMAN             Reviewed;         150 AA.
AC   A0A1W2PS18;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 1.
DT   03-AUG-2022, entry version 21.
DE   RecName: Full=Transmembrane protein PMIS2 {ECO:0000305};
GN   Name=PMIS2 {ECO:0000312|HGNC:HGNC:53649};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- FUNCTION: May play a role in spermatozoa mobility.
CC       {ECO:0000250|UniProtKB:Q8CES1}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
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DR   EMBL; AC002115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1W2PS18; -.
DR   BioMuta; ENSG00000283758; -.
DR   Ensembl; ENST00000640449.2; ENSP00000492557.1; ENSG00000283758.2.
DR   MANE-Select; ENST00000640449.2; ENSP00000492557.1; NM_001395412.1; NP_001382341.1.
DR   GeneCards; PMIS2; -.
DR   HGNC; HGNC:53649; PMIS2.
DR   HPA; ENSG00000283758; Tissue enhanced (brain).
DR   neXtProt; NX_A0A1W2PS18; -.
DR   VEuPathDB; HostDB:ENSG00000283758; -.
DR   GeneTree; ENSGT00950000183147; -.
DR   OMA; EDAYINS; -.
DR   ChiTaRS; PMIS2; human.
DR   Pharos; A0A1W2PS18; Tdark.
DR   PRO; PR:A0A1W2PS18; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; A0A1W2PS18; protein.
DR   Bgee; ENSG00000283758; Expressed in left testis and 9 other tissues.
DR   ExpressionAtlas; A0A1W2PS18; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   InterPro; IPR007593; CD225/Dispanin_fam.
DR   Pfam; PF04505; CD225; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..150
FT                   /note="Transmembrane protein PMIS2"
FT                   /id="PRO_0000444534"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..23
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   150 AA;  15819 MW;  D21A73D63B25A5FA CRC64;
     MALKPPSATQ PAPNAPATPD APPTTGDPGA SAAPGSPTTT GGPGAPAEVP QEPQEPTQTP
     EELAFYAPNY LCLTIFAILL FPPFGLAALY FSYEGSWTQK PTSMLPPLQT MKANQNSEWE
     EAYINSGRTG WFGAFVVMIG LGIIYGLVLY