PML39_YEAST
ID PML39_YEAST Reviewed; 334 AA.
AC Q03760; D6W0H7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Pre-mRNA leakage protein 39;
DE AltName: Full=39 kDa pre-mRNA leakage protein;
GN Name=PML39; OrderedLocusNames=YML107C; ORFNames=YM8339.12;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP IDENTIFICATION OF PROBABLE INITIATION SITE.
RX PubMed=12748633; DOI=10.1038/nature01644;
RA Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.;
RT "Sequencing and comparison of yeast species to identify genes and
RT regulatory elements.";
RL Nature 423:241-254(2003).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH MLP1 AND MLP2.
RX PubMed=16162818; DOI=10.1091/mbc.e05-06-0527;
RA Palancade B., Zuccolo M., Loeillet S., Nicolas A., Doye V.;
RT "Pml39, a novel protein of the nuclear periphery required for nuclear
RT retention of improper messenger ribonucleoparticles.";
RL Mol. Biol. Cell 16:5258-5268(2005).
CC -!- FUNCTION: Involved in the nuclear retention of improperly spliced pre-
CC mRNAs. {ECO:0000269|PubMed:16162818}.
CC -!- SUBUNIT: Interacts with MLP1 and MLP2. {ECO:0000269|PubMed:16162818}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:16162818}; Peripheral membrane protein
CC {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16162818}; Lumenal
CC side {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16162818}.
CC Note=Associated with a subset of nuclear pores opposite to the
CC nucleolus.
CC -!- MISCELLANEOUS: Present with 2205 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA89111.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; Z49210; CAA89111.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK006946; DAA09791.1; -; Genomic_DNA.
DR PIR; S53965; S53965.
DR RefSeq; NP_013600.2; NM_001182469.1.
DR AlphaFoldDB; Q03760; -.
DR BioGRID; 35036; 183.
DR DIP; DIP-4523N; -.
DR IntAct; Q03760; 1.
DR MINT; Q03760; -.
DR STRING; 4932.YML107C; -.
DR MaxQB; Q03760; -.
DR PaxDb; Q03760; -.
DR PRIDE; Q03760; -.
DR EnsemblFungi; YML107C_mRNA; YML107C; YML107C.
DR GeneID; 854864; -.
DR KEGG; sce:YML107C; -.
DR SGD; S000004575; PML39.
DR VEuPathDB; FungiDB:YML107C; -.
DR eggNOG; ENOG502S4N7; Eukaryota.
DR HOGENOM; CLU_831968_0_0_1; -.
DR InParanoid; Q03760; -.
DR OMA; CHAIMTI; -.
DR BioCyc; YEAST:G3O-32690-MON; -.
DR PRO; PR:Q03760; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; Q03760; protein.
DR GO; GO:0031965; C:nuclear membrane; IDA:SGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0051237; P:maintenance of RNA location; IMP:SGD.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR InterPro; IPR012935; Znf_C3HC-like.
DR Pfam; PF07967; zf-C3HC; 1.
PE 1: Evidence at protein level;
KW Membrane; mRNA transport; Nucleus; Reference proteome; Transport.
FT CHAIN 1..334
FT /note="Pre-mRNA leakage protein 39"
FT /id="PRO_0000203243"
SQ SEQUENCE 334 AA; 39207 MW; 49A05DB003EC4E6B CRC64;
MEKDALEVRL KSIRHSLDKN TKLLPGKYRN TLGERLITKW RYKKKSHNGS SMLPEKCKSH
VQLYDDLVQE SSKHFVGFRL HDLRALLKRI CSIQNYTRHV LIEWDVRWVN PLTLASKGWE
PYQSASQSQV PFKCCCCHAI MTIPLLKNGD DVADYTMKLN EKIWNSNIIG NHLQKCPWRE
NQVDLNKEYY LSSQNLIREI ERIHTEIDRI VSGSNEFSLK RNSSRIFHYL SEKEIQKLAF
FFDCKDYSLV GLLLLGYTKF QKDDLVQCTA CFHRASLKKL EYTEFNGHAL WCRYYNKELL
PTMLLELIGK EDKLITKLGV GERLNKLEAV LQTL
