AT13B_ARATH
ID AT13B_ARATH Reviewed; 625 AA.
AC F4J8V5; Q0WQ00; Q9LSA0;
DT 11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Autophagy-related protein 13b {ECO:0000303|PubMed:12114572};
DE Short=AtAPG13b {ECO:0000303|PubMed:12114572};
GN Name=ATG13B {ECO:0000303|PubMed:21984698};
GN OrderedLocusNames=At3g18770 {ECO:0000312|Araport:AT3G18770};
GN ORFNames=MVE11.13 {ECO:0000312|EMBL:BAB01803.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-625.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12114572; DOI=10.1104/pp.011024;
RA Hanaoka H., Noda T., Shirano Y., Kato T., Hayashi H., Shibata D.,
RA Tabata S., Ohsumi Y.;
RT "Leaf senescence and starvation-induced chlorosis are accelerated by the
RT disruption of an Arabidopsis autophagy gene.";
RL Plant Physiol. 129:1181-1193(2002).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21984698; DOI=10.1105/tpc.111.090993;
RA Suttangkakul A., Li F., Chung T., Vierstra R.D.;
RT "The ATG1/ATG13 protein kinase complex is both a regulator and a target of
RT autophagic recycling in Arabidopsis.";
RL Plant Cell 23:3761-3779(2011).
CC -!- FUNCTION: Involved in autophagy in a nutritional condition dependent
CC manner. The ATG1-ATG13 protein kinase complex regulates downstream
CC events required for autophagosome enclosure and/or vacuolar delivery.
CC Becomes a target of autophagy under nutrient starvation (By
CC similarity). Connects autophagy to plant nutritional status
CC (PubMed:21984698). {ECO:0000250|UniProtKB:Q9SCK0,
CC ECO:0000269|PubMed:21984698}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome
CC {ECO:0000250|UniProtKB:Q9SCK0}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions. The double mutant plants atg13a-1 and atg13b-2, or atg13a-2
CC and atg13b-2 are hypersensitive to nitrogen or carbon starvation and
CC show early senescence. {ECO:0000269|PubMed:21984698}.
CC -!- SIMILARITY: Belongs to the ATG13 family. Plant subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB01803.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB026654; BAB01803.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE76144.1; -; Genomic_DNA.
DR EMBL; AK228910; BAF00799.1; -; mRNA.
DR RefSeq; NP_188507.1; NM_112763.5.
DR AlphaFoldDB; F4J8V5; -.
DR SMR; F4J8V5; -.
DR STRING; 3702.AT3G18770.1; -.
DR iPTMnet; F4J8V5; -.
DR PaxDb; F4J8V5; -.
DR PRIDE; F4J8V5; -.
DR ProteomicsDB; 246818; -.
DR EnsemblPlants; AT3G18770.1; AT3G18770.1; AT3G18770.
DR GeneID; 821408; -.
DR Gramene; AT3G18770.1; AT3G18770.1; AT3G18770.
DR KEGG; ath:AT3G18770; -.
DR Araport; AT3G18770; -.
DR TAIR; locus:2094024; AT3G18770.
DR eggNOG; KOG4573; Eukaryota.
DR HOGENOM; CLU_030687_1_0_1; -.
DR InParanoid; F4J8V5; -.
DR OMA; GPLPCKP; -.
DR OrthoDB; 637634at2759; -.
DR PRO; PR:F4J8V5; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; F4J8V5; baseline and differential.
DR Genevisible; F4J8V5; AT.
DR GO; GO:1990316; C:Atg1/ULK1 kinase complex; IBA:GO_Central.
DR GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR GO; GO:0000423; P:mitophagy; IBA:GO_Central.
DR GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central.
DR GO; GO:0034497; P:protein localization to phagophore assembly site; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.900.10; -; 1.
DR InterPro; IPR040182; ATG13.
DR InterPro; IPR018731; Atg13_N.
DR InterPro; IPR036570; HORMA_dom_sf.
DR PANTHER; PTHR13430; PTHR13430; 1.
DR Pfam; PF10033; ATG13; 1.
PE 2: Evidence at transcript level;
KW Autophagy; Cytoplasmic vesicle; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..625
FT /note="Autophagy-related protein 13b"
FT /id="PRO_0000434627"
FT REGION 322..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..517
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 559
FT /note="C -> Y (in Ref. 3; BAF00799)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 625 AA; 69454 MW; 9179580038344851 CRC64;
MSSSHNRSNN NNSEGAKAEQ IIFEFFAKSL HIILESRTPF MSSRNFSGEQ MICSPSSSSS
SSSSVRPRDK WFNLALRECP AALESFDIGR RSSLEPLVVD VVLVVRPLVG DQSGKRELIR
NFSGKDYQSG WNSDQDELGC ETKNEQIIER WVVQYDNRKI RESVTTSSRR SSSNKLQVMY
KKATLLLRSL FVMVRLLPAY KIFRELNSSG QIFKFKLVPR VPSIVEPFTR KEEAEMQKFS
FTPVETICGR LCLSVLYRSL SDVSCEHSTP MSPTFITDYV GSPLADPLKR FPSLPLSYGS
PPLLPFQRRH SWSFDRYKAS PPSVSCSPSP TRSDSHALVS HPCSRHLPPH PSDIPTGRRK
ESYPEEYSPC QDFSPPPSPS APKHAVPRGI TRTESAPVRI PAPTFQSKEN VVAPSAHLKL
SRHASLKPVR NLGPGESGAA IDKLFLYGRD DFRRPSGVRP SSSSSPRISF SRSSSRSFQD
DFDDPDFPCP FDVEYDDITD RNSRPGSFDH RGDIHEPFDS SGSYPKKSQD AAVGALVRML
KKAPPLRQDV SESSRPEICS NNNKPAGAHE IAVASITASG IALASKTTAD ALEELRSYKE
MKNHLLLGQS TSNPSSVTIT SPFDV
