ID   PMP22_HORSE             Reviewed;         159 AA.
AC   Q6WL85;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Peripheral myelin protein 22;
DE            Short=PMP-22;
GN   Name=PMP22;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Blechynden L.M., Akkari P.A., Hilbert B.J., Laing N.G.;
RT   "Characterization of the equine MPZ, PMP22 and GJB1 genes and their
RT   evaluation as candidate genes for equine idiopathic laryngeal hemiplegia.";
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Might be involved in growth regulation, and in myelinization
CC       in the peripheral nervous system. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY280708; AAQ17534.1; -; mRNA.
DR   RefSeq; NP_001075405.1; NM_001081936.1.
DR   RefSeq; XP_005597077.1; XM_005597020.2.
DR   RefSeq; XP_005597078.1; XM_005597021.2.
DR   AlphaFoldDB; Q6WL85; -.
DR   SMR; Q6WL85; -.
DR   STRING; 9796.ENSECAP00000022747; -.
DR   PaxDb; Q6WL85; -.
DR   Ensembl; ENSECAT00000027190; ENSECAP00000022747; ENSECAG00000025178.
DR   GeneID; 100034146; -.
DR   KEGG; ecb:100034146; -.
DR   CTD; 5376; -.
DR   VGNC; VGNC:21615; PMP22.
DR   GeneTree; ENSGT00950000182696; -.
DR   HOGENOM; CLU_138632_1_0_1; -.
DR   InParanoid; Q6WL85; -.
DR   OMA; VRHTDWH; -.
DR   OrthoDB; 1513895at2759; -.
DR   TreeFam; TF330414; -.
DR   Proteomes; UP000002281; Chromosome 11.
DR   Bgee; ENSECAG00000025178; Expressed in articular cartilage of joint and 23 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0032060; P:bleb assembly; IEA:Ensembl.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0008219; P:cell death; IEA:Ensembl.
DR   GO; GO:0032288; P:myelin assembly; IBA:GO_Central.
DR   InterPro; IPR003936; PMP22.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR004032; PMP22_EMP_MP20.
DR   PANTHER; PTHR10671:SF7; PTHR10671:SF7; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01453; EPMEMFAMILY.
DR   PRINTS; PR01458; PMYELIN22.
DR   PROSITE; PS01221; PMP22_1; 1.
DR   PROSITE; PS01222; PMP22_2; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell membrane; Glycoprotein; Growth arrest; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..159
FT                   /note="Peripheral myelin protein 22"
FT                   /id="PRO_0000164649"
FT   TOPO_DOM        1
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        32..64
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        92..95
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        120..133
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        157..159
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   159 AA;  17648 MW;  E4AFA30B12457406 CRC64;
     MLLLLLGIIV LHVAVLVLLF VATIVSQWIV GNGHATDLWQ NCSTTSGNVQ HCLSSSANEW
     LQSVQATMIL SIIFSVLSLF LFFCQLFTLT KGGRFYITGI FQILAGLCVM SAASIYTVRH
     PEWHLDSAYS YGFAYILAWV AFPLALLSGV VYVILRKRE