ID   PMP22_PONAB             Reviewed;         160 AA.
AC   Q5RAZ3;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Peripheral myelin protein 22;
DE            Short=PMP-22;
GN   Name=PMP22;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Might be involved in growth regulation, and in myelinization
CC       in the peripheral nervous system. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
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DR   EMBL; CR858868; CAH91067.1; -; mRNA.
DR   RefSeq; NP_001125617.1; NM_001132145.1.
DR   RefSeq; XP_009249591.1; XM_009251316.1.
DR   AlphaFoldDB; Q5RAZ3; -.
DR   SMR; Q5RAZ3; -.
DR   GeneID; 100172535; -.
DR   KEGG; pon:100172535; -.
DR   CTD; 5376; -.
DR   InParanoid; Q5RAZ3; -.
DR   OrthoDB; 1513895at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR003936; PMP22.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR004032; PMP22_EMP_MP20.
DR   PANTHER; PTHR10671:SF7; PTHR10671:SF7; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01453; EPMEMFAMILY.
DR   PRINTS; PR01458; PMYELIN22.
DR   PROSITE; PS01221; PMP22_1; 1.
DR   PROSITE; PS01222; PMP22_2; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell membrane; Glycoprotein; Growth arrest; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..160
FT                   /note="Peripheral myelin protein 22"
FT                   /id="PRO_0000256844"
FT   TOPO_DOM        1
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        32..64
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        92..95
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        120..133
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        157..160
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   160 AA;  17891 MW;  7ECF7F91BED0CF9D CRC64;
     MLLLLLSIIV LHVAVLVLLF VSTIVSQWIV GNGHATDLWQ NCSTSSSGNV HHCFSSSPNE
     WLQSVQATMI LSIIFSILSL FLFFCQLFTL TKGGRFYITG IFQILAGLCV MSAAAIYTVR
     HPEWHLNSDY SYGFAYILAW VAFPLALLSG VIYVILRKRE