PMP22_RAT
ID PMP22_RAT Reviewed; 160 AA.
AC P25094;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Peripheral myelin protein 22;
DE Short=PMP-22;
DE AltName: Full=Protein CD25;
DE AltName: Full=SR13 myelin protein;
DE AltName: Full=Schwann cell membrane glycoprotein;
DE Short=SAG;
GN Name=Pmp22; Synonyms=Cd25, Pmp-22;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Sciatic nerve;
RX PubMed=1935894; DOI=10.1002/j.1460-2075.1991.tb04933.x;
RA Spreyer P., Kuhn G., Hanemann C.O., Gillen C., Schaal H., Kuhn R.,
RA Lemke G., Mueller H.W.;
RT "Axon-regulated expression of a Schwann cell transcript that is homologous
RT to a 'growth arrest-specific' gene.";
RL EMBO J. 10:3661-3668(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Sciatic nerve;
RX PubMed=1714591; DOI=10.1073/pnas.88.16.7195;
RA Welcher A.A., Suter U., de Leon M., Snipes G.J., Shooter E.M.;
RT "A myelin protein is encoded by the homologue of a growth arrest-specific
RT gene.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:7195-7199(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1287719; DOI=10.1016/s0079-6123(08)61748-3;
RA Welcher A.A., de Leon M., Suter U., Snipes G.J., Meakin S.O., Shooter E.M.;
RT "Isolation of transcriptionally regulated sequences associated with
RT neuronal and non-neuronal cell interactions.";
RL Prog. Brain Res. 94:163-176(1992).
RN [4]
RP PROTEIN SEQUENCE OF 1-30, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=1376775; DOI=10.1523/jneurosci.12-06-02177.1992;
RA Dieperink M.E., O'Neill A., Magnoni G., Wollmann R.L., Heinrikson R.L.,
RA Zucher-Neely H.A., Stefansson K.;
RT "SAG: a Schwann cell membrane glycoprotein.";
RL J. Neurosci. 12:2177-2185(1992).
CC -!- FUNCTION: Might be involved in growth regulation, and in myelinization
CC in the peripheral nervous system.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Found exclusively in the peripheral nervous system.
CC Present in both myelinating and nonmyelinating Schwann cells. Found in
CC the tumors of Schwann cell lineage where axons are present
CC (neurofibromas) but not where axons are absent (schwannomas).
CC {ECO:0000269|PubMed:1376775}.
CC -!- DEVELOPMENTAL STAGE: Levels increase between embryonic day 21 (E21) and
CC postnatal day 1 (P1) and then gradually increase up to P15. There is a
CC slight increase between P15 and adulthood.
CC {ECO:0000269|PubMed:1376775}.
CC -!- INDUCTION: Strongly down-regulated in the initial phase after sciatic
CC nerve injury.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
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DR EMBL; X62431; CAA44297.1; -; mRNA.
DR EMBL; M69139; AAA73063.1; -; mRNA.
DR EMBL; S55427; AAB25374.1; -; mRNA.
DR PIR; A41144; A41144.
DR RefSeq; NP_058733.1; NM_017037.1.
DR RefSeq; XP_006246646.1; XM_006246584.3.
DR AlphaFoldDB; P25094; -.
DR SMR; P25094; -.
DR STRING; 10116.ENSRNOP00000051201; -.
DR ChEMBL; CHEMBL2007624; -.
DR GlyGen; P25094; 1 site.
DR PaxDb; P25094; -.
DR Ensembl; ENSRNOT00000081415; ENSRNOP00000069909; ENSRNOG00000003338.
DR GeneID; 24660; -.
DR KEGG; rno:24660; -.
DR UCSC; RGD:3359; rat.
DR CTD; 5376; -.
DR RGD; 3359; Pmp22.
DR eggNOG; ENOG502S0F5; Eukaryota.
DR GeneTree; ENSGT00950000182696; -.
DR InParanoid; P25094; -.
DR OMA; VRHTDWH; -.
DR OrthoDB; 1513895at2759; -.
DR PhylomeDB; P25094; -.
DR TreeFam; TF330414; -.
DR PRO; PR:P25094; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000003338; Expressed in lung and 20 other tissues.
DR Genevisible; P25094; RN.
DR GO; GO:0005923; C:bicellular tight junction; IDA:RGD.
DR GO; GO:0009986; C:cell surface; ISO:RGD.
DR GO; GO:0043218; C:compact myelin; IDA:RGD.
DR GO; GO:0016021; C:integral component of membrane; IDA:RGD.
DR GO; GO:0008305; C:integrin complex; ISO:RGD.
DR GO; GO:0043256; C:laminin complex; ISO:RGD.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0003774; F:cytoskeletal motor activity; ISO:RGD.
DR GO; GO:0030036; P:actin cytoskeleton organization; ISO:RGD.
DR GO; GO:0008344; P:adult locomotory behavior; ISO:RGD.
DR GO; GO:0007628; P:adult walking behavior; ISO:RGD.
DR GO; GO:0070842; P:aggresome assembly; ISO:RGD.
DR GO; GO:0006914; P:autophagy; ISO:RGD.
DR GO; GO:0061564; P:axon development; ISO:RGD.
DR GO; GO:0071711; P:basement membrane organization; ISO:RGD.
DR GO; GO:0032060; P:bleb assembly; ISO:RGD.
DR GO; GO:0007155; P:cell adhesion; ISO:RGD.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0008219; P:cell death; ISO:RGD.
DR GO; GO:0030154; P:cell differentiation; IDA:RGD.
DR GO; GO:0044255; P:cellular lipid metabolic process; ISO:RGD.
DR GO; GO:0051641; P:cellular localization; ISO:RGD.
DR GO; GO:0034605; P:cellular response to heat; ISO:RGD.
DR GO; GO:0034620; P:cellular response to unfolded protein; ISO:RGD.
DR GO; GO:0008203; P:cholesterol metabolic process; ISO:RGD.
DR GO; GO:0010761; P:fibroblast migration; ISO:RGD.
DR GO; GO:0042063; P:gliogenesis; ISO:RGD.
DR GO; GO:0006955; P:immune response; ISO:RGD.
DR GO; GO:0030032; P:lamellipodium assembly; ISO:RGD.
DR GO; GO:0007618; P:mating; ISO:RGD.
DR GO; GO:0031579; P:membrane raft organization; ISO:RGD.
DR GO; GO:0061744; P:motor behavior; ISO:RGD.
DR GO; GO:0010259; P:multicellular organism aging; ISO:RGD.
DR GO; GO:0035264; P:multicellular organism growth; ISO:RGD.
DR GO; GO:0055001; P:muscle cell development; ISO:RGD.
DR GO; GO:0032288; P:myelin assembly; ISO:RGD.
DR GO; GO:0042552; P:myelination; IDA:RGD.
DR GO; GO:0022011; P:myelination in peripheral nervous system; ISO:RGD.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:BHF-UCL.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
DR GO; GO:0010977; P:negative regulation of neuron projection development; IDA:BHF-UCL.
DR GO; GO:0098529; P:neuromuscular junction development, skeletal muscle fiber; ISO:RGD.
DR GO; GO:0050905; P:neuromuscular process; ISO:RGD.
DR GO; GO:0019228; P:neuronal action potential; ISO:RGD.
DR GO; GO:0019227; P:neuronal action potential propagation; ISO:RGD.
DR GO; GO:0045161; P:neuronal ion channel clustering; ISO:RGD.
DR GO; GO:0030913; P:paranodal junction assembly; ISO:RGD.
DR GO; GO:0007422; P:peripheral nervous system development; ISO:RGD.
DR GO; GO:0048936; P:peripheral nervous system neuron axonogenesis; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:0010498; P:proteasomal protein catabolic process; ISO:RGD.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISO:RGD.
DR GO; GO:2001233; P:regulation of apoptotic signaling pathway; ISO:RGD.
DR GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
DR GO; GO:0034350; P:regulation of glial cell apoptotic process; ISO:RGD.
DR GO; GO:0050727; P:regulation of inflammatory response; ISO:RGD.
DR GO; GO:0071900; P:regulation of protein serine/threonine kinase activity; ISO:RGD.
DR GO; GO:0010624; P:regulation of Schwann cell proliferation; ISO:RGD.
DR GO; GO:0009617; P:response to bacterium; ISO:RGD.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; ISO:RGD.
DR GO; GO:0014044; P:Schwann cell development; ISO:RGD.
DR GO; GO:0014037; P:Schwann cell differentiation; ISO:RGD.
DR GO; GO:0036135; P:Schwann cell migration; ISO:RGD.
DR GO; GO:0051146; P:striated muscle cell differentiation; ISO:RGD.
DR GO; GO:0019226; P:transmission of nerve impulse; ISO:RGD.
DR GO; GO:0060005; P:vestibular reflex; ISO:RGD.
DR InterPro; IPR003936; PMP22.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR004032; PMP22_EMP_MP20.
DR PANTHER; PTHR10671:SF7; PTHR10671:SF7; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01453; EPMEMFAMILY.
DR PRINTS; PR01458; PMYELIN22.
DR PROSITE; PS01221; PMP22_1; 1.
DR PROSITE; PS01222; PMP22_2; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell membrane; Direct protein sequencing; Glycoprotein;
KW Growth arrest; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..160
FT /note="Peripheral myelin protein 22"
FT /id="PRO_0000164652"
FT TOPO_DOM 1
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 2..31
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 32..64
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..91
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 92..95
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..119
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 120..133
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..156
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 157..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 22
FT /note="S -> K (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 30
FT /note="V -> E (in Ref. 1; CAA44297)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 160 AA; 17946 MW; 8DB9B2F2CF6D4903 CRC64;
MLLLLLGILF LHIAVLVLLF VSTIVSQWLV GNGHRTDLWQ NCTTSALGAV QHCYSSSVSE
WLQSVQATMI LSVIFSVLSL FLFFCQLFTL TKGGRFYITG VFQILAGLCV MSAAAIYTVR
HSEWHVNNDY SYGFAYILAW VAFPLALLSG IIYVILRKRE
