ID   PMP23_PIG               Reviewed;         153 AA.
AC   P49930;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Antibacterial peptide PMAP-23;
DE   AltName: Full=Myeloid antibacterial peptide 23;
DE   Flags: Precursor;
GN   Name=PMAP23;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SYNTHESIS OF 131-153.
RC   TISSUE=Bone marrow;
RX   PubMed=8132502; DOI=10.1016/s0021-9258(17)37128-4;
RA   Zanetti M., Storici P., Tossi A., Scocchi M., Gennaro R.;
RT   "Molecular cloning and chemical synthesis of a novel antibacterial peptide
RT   derived from pig myeloid cells.";
RL   J. Biol. Chem. 269:7855-7858(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RA   Zhao C., Lehrer R.I.;
RL   Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exerts antimicrobial activity against both Gram-positive and
CC       negative bacteria at concentrations of 2-16 micro molar. Its activity
CC       appears to be mediated by its ability to damage bacterial membranes.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
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DR   EMBL; L26053; AAA31103.1; -; mRNA.
DR   EMBL; Y16624; CAA76328.1; -; Genomic_DNA.
DR   PIR; A53421; A53421.
DR   RefSeq; NP_001123448.1; NM_001129976.1.
DR   AlphaFoldDB; P49930; -.
DR   SMR; P49930; -.
DR   STRING; 9823.ENSSSCP00000025756; -.
DR   PaxDb; P49930; -.
DR   PeptideAtlas; P49930; -.
DR   PRIDE; P49930; -.
DR   GeneID; 100170138; -.
DR   KEGG; ssc:100170138; -.
DR   CTD; 100170138; -.
DR   eggNOG; ENOG502SAES; Eukaryota.
DR   InParanoid; P49930; -.
DR   OrthoDB; 1534863at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   InterPro; IPR001894; Cathelicidin-like.
DR   InterPro; IPR018216; Cathelicidin_CS.
DR   InterPro; IPR046350; Cystatin_sf.
DR   PANTHER; PTHR10206; PTHR10206; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00946; CATHELICIDINS_1; 1.
DR   PROSITE; PS00947; CATHELICIDINS_2; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Pyrrolidone carboxylic acid;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..130
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000004732"
FT   PEPTIDE         131..153
FT                   /note="Antibacterial peptide PMAP-23"
FT                   /id="PRO_0000004733"
FT   REGION          61..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         30
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P19660"
FT   DISULFID        85..96
FT                   /evidence="ECO:0000250"
FT   DISULFID        107..124
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   153 AA;  17486 MW;  7ADAA22B6C206000 CRC64;
     METQRASLCL GRWSLWLLLL GLVVPSASAQ ALSYREAVLR AVDRLNEQSS EANLYRLLEL
     DQPPKADEDP GTPKPVSFTV KETVCPRPTR QPPELCDFKE NGRVKQCVGT VTLKEIRGNF
     DITCNQLQSV RIIDLLWRVR RPQKPKFVTV WVR