ID   PMP2_YEAST              Reviewed;          43 AA.
AC   P40975; D3DLN2;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Plasma membrane ATPase proteolipid 2;
DE   Flags: Precursor;
GN   Name=PMP2; OrderedLocusNames=YEL017C-A; ORFNames=YEL017BC;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 6-43.
RC   STRAIN=ATCC 201238 / W303-1B;
RX   PubMed=8063750; DOI=10.1016/s0021-9258(17)31958-0;
RA   Navarre C., Catty P., Leterme S., Dietrich F.S., Goffeau A.;
RT   "Two distinct genes encode small isoproteolipids affecting plasma membrane
RT   H(+)-ATPase activity of Saccharomyces cerevisiae.";
RL   J. Biol. Chem. 269:21262-21268(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA   Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA   Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA   Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- SUBUNIT: Monomer and homodimer. Associated with the 100 kDa subunit of
CC       the plasma membrane H(+)-ATPase.
CC   -!- SUBCELLULAR LOCATION: Cell membrane.
CC   -!- MISCELLANEOUS: Present with 74700 molecules/cell in log phase SD
CC       medium. {ECO:0000269|PubMed:14562106}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-3 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; X79370; CAA55915.1; -; Genomic_DNA.
DR   EMBL; U18530; AAB64509.1; -; Genomic_DNA.
DR   EMBL; AY692935; AAT92954.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07636.1; -; Genomic_DNA.
DR   PIR; A53927; A53927.
DR   RefSeq; NP_010898.1; NM_001180029.1.
DR   AlphaFoldDB; P40975; -.
DR   SMR; P40975; -.
DR   BioGRID; 36713; 51.
DR   DIP; DIP-7629N; -.
DR   IntAct; P40975; 18.
DR   MINT; P40975; -.
DR   STRING; 4932.YEL017C-A; -.
DR   PaxDb; P40975; -.
DR   TopDownProteomics; P40975; -.
DR   EnsemblFungi; YEL017C-A_mRNA; YEL017C-A; YEL017C-A.
DR   GeneID; 856697; -.
DR   KEGG; sce:YEL017C-A; -.
DR   SGD; S000002103; PMP2.
DR   VEuPathDB; FungiDB:YEL017C-A; -.
DR   eggNOG; ENOG502SFZ7; Eukaryota.
DR   GeneTree; ENSGT00940000176551; -.
DR   HOGENOM; CLU_219858_0_0_1; -.
DR   InParanoid; P40975; -.
DR   BioCyc; YEAST:G3O-30347-MON; -.
DR   PRO; PR:P40975; -.
DR   Proteomes; UP000002311; Chromosome V.
DR   GO; GO:0071944; C:cell periphery; HDA:SGD.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; HDA:SGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IDA:SGD.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030234; F:enzyme regulator activity; IGI:SGD.
DR   GO; GO:0032781; P:positive regulation of ATP-dependent activity; IGI:SGD.
DR   InterPro; IPR012589; Pmp1/Pmp2.
DR   Pfam; PF08114; PMP1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   PROPEP          1..5
FT                   /evidence="ECO:0000269|PubMed:8063750"
FT                   /id="PRO_0000022073"
FT   CHAIN           6..43
FT                   /note="Plasma membrane ATPase proteolipid 2"
FT                   /id="PRO_0000022074"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..43
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   43 AA;  4848 MW;  F02403E502225434 CRC64;
     MLMSTLPGGV ILVFILVGLA CIAIISTIIY RKWQARQRGL QRF