ID   PMP36_PIG               Reviewed;         166 AA.
AC   P49931;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Antibacterial peptide PMAP-36;
DE   AltName: Full=Myeloid antibacterial peptide 36;
DE   Flags: Precursor;
GN   Name=PMAP36;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SYNTHESIS OF 130-166.
RC   TISSUE=Bone marrow;
RX   PubMed=8293820; DOI=10.1016/0014-5793(94)80214-9;
RA   Storici P., Scocchi M., Tossi A., Gennaro R., Zanetti M.;
RT   "Chemical synthesis and biological activity of a novel antibacterial
RT   peptide deduced from a pig myeloid cDNA.";
RL   FEBS Lett. 337:303-307(1994).
CC   -!- FUNCTION: Exerts antimicrobial activity against both Gram-positive and
CC       negative bacteria. Its activity appears to be mediated by its ability
CC       to damage bacterial membranes.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
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DR   EMBL; L29125; AAA31070.1; -; mRNA.
DR   PIR; S41731; S41731.
DR   RefSeq; NP_001123437.1; NM_001129965.1.
DR   AlphaFoldDB; P49931; -.
DR   SMR; P49931; -.
DR   PeptideAtlas; P49931; -.
DR   PRIDE; P49931; -.
DR   GeneID; 100170124; -.
DR   KEGG; ssc:100170124; -.
DR   CTD; 100170124; -.
DR   eggNOG; ENOG502SAES; Eukaryota.
DR   InParanoid; P49931; -.
DR   OrthoDB; 1534863at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   InterPro; IPR001894; Cathelicidin-like.
DR   InterPro; IPR018216; Cathelicidin_CS.
DR   InterPro; IPR046350; Cystatin_sf.
DR   PANTHER; PTHR10206; PTHR10206; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00946; CATHELICIDINS_1; 1.
DR   PROSITE; PS00947; CATHELICIDINS_2; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..129
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000004734"
FT   PEPTIDE         130..166
FT                   /note="Antibacterial peptide PMAP-36"
FT                   /id="PRO_0000004735"
FT   DISULFID        85..96
FT                   /evidence="ECO:0000250"
FT   DISULFID        107..124
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   166 AA;  18647 MW;  94B13C69709DA64B CRC64;
     METQRASLCL GRWSLWLLLL GLVVPSASAQ ALSYREAVLR AVDRLNEQSS EANLYRLLEL
     DQPPKADEDP GTPKPVSFTV KETVCPRPTW RPPELCDFKE NGRVKQCVGT VTLNPSNDPL
     DINCDEIQSV GRFRRLRKKT RKRLKKIGKV LKWIPPIVGS IPLGCG