ID   PMP37_PIG               Reviewed;         167 AA.
AC   P49932;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Antibacterial peptide PMAP-37;
DE   AltName: Full=Myeloid antibacterial peptide 37;
DE   Flags: Precursor;
GN   Name=PMAP37;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SYNTHESIS OF 131-167.
RC   TISSUE=Bone marrow;
RX   PubMed=7737198; DOI=10.1111/j.1432-1033.1995.tb20344.x;
RA   Tossi A., Scocchi M., Zanetti M., Storici P., Gennaro R.;
RT   "PMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA
RT   cloning, chemical synthesis and activity.";
RL   Eur. J. Biochem. 228:941-946(1995).
CC   -!- FUNCTION: Exerts antimicrobial activity against both Gram-positive and
CC       negative bacteria with minimal inhibitory concentrations ranging over
CC       1-4 micro molar. Its activity appears to be mediated by its ability to
CC       damage bacterial membranes.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
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DR   EMBL; L39641; AAA63447.1; -; mRNA.
DR   PIR; S68967; S68967.
DR   AlphaFoldDB; P49932; -.
DR   SMR; P49932; -.
DR   STRING; 9823.ENSSSCP00000012102; -.
DR   PaxDb; P49932; -.
DR   PeptideAtlas; P49932; -.
DR   eggNOG; ENOG502SAES; Eukaryota.
DR   InParanoid; P49932; -.
DR   ChiTaRS; NPG4; pig.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR001894; Cathelicidin-like.
DR   InterPro; IPR018216; Cathelicidin_CS.
DR   InterPro; IPR046350; Cystatin_sf.
DR   PANTHER; PTHR10206; PTHR10206; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00946; CATHELICIDINS_1; 1.
DR   PROSITE; PS00947; CATHELICIDINS_2; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..130
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000004736"
FT   PEPTIDE         131..167
FT                   /note="Antibacterial peptide PMAP-37"
FT                   /id="PRO_0000004737"
FT   DISULFID        85..96
FT                   /evidence="ECO:0000250"
FT   DISULFID        107..124
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   167 AA;  18927 MW;  20F2E95966432992 CRC64;
     METQRASLCL GRWSLWLLLL ALVVPSASAQ ALSYREAVLR AVDRLNEQSS EANLYRLLEL
     DQPPKADEDP GTPKPVSFTV KETVCPRPTW RPPELCDFKE NGRVKQCVGT VTLDQIKDPL
     DITCNEIQSV GLLSRLRDFL SDRGRRLGEK IERIGQKIKD LSEFFQS