ID   PMP3_CRYNJ              Reviewed;          57 AA.
AC   P0CS18; Q55V58; Q5KL24;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Plasma membrane proteolipid 3;
GN   Name=PMP3; OrderedLocusNames=CNC01010;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Plays a role in the regulation of membrane potential. Could
CC       mediate a proton leak (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0057 (PMP3) family. {ECO:0000305}.
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DR   EMBL; AE017343; AAW42114.1; -; Genomic_DNA.
DR   RefSeq; XP_569421.1; XM_569421.1.
DR   AlphaFoldDB; P0CS18; -.
DR   STRING; 214684.P0CS18; -.
DR   PaxDb; P0CS18; -.
DR   EnsemblFungi; AAW42114; AAW42114; CNC01010.
DR   VEuPathDB; FungiDB:CNC01010; -.
DR   eggNOG; KOG1773; Eukaryota.
DR   HOGENOM; CLU_107649_6_2_1; -.
DR   InParanoid; P0CS18; -.
DR   OMA; VHAIWVI; -.
DR   OrthoDB; 1623763at2759; -.
DR   Proteomes; UP000002149; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000612; PMP3.
DR   PANTHER; PTHR21659; PTHR21659; 1.
DR   Pfam; PF01679; Pmp3; 1.
DR   PROSITE; PS01309; UPF0057; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..57
FT                   /note="Plasma membrane proteolipid 3"
FT                   /id="PRO_0000247910"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   57 AA;  6275 MW;  1ABFE94FFDC8CA2D CRC64;
     MAFTCSDIFK IILAIILPPL GVFLERGCGA DLLINILLTI LGYIPGIIHA LYIILKY