ID   PMP3_SCHPO              Reviewed;          57 AA.
AC   Q9C1W4;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2012, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Plasma membrane proteolipid 3;
GN   Name=pmp3; ORFNames=SPBC713.11c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   REVISION OF GENE MODEL.
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
RN   [3]
RP   FUNCTION.
RX   PubMed=16603158; DOI=10.1016/j.febslet.2006.03.065;
RA   Wang L.-Y., Shiozaki K.;
RT   "The fission yeast stress MAPK cascade regulates the pmp3+ gene that
RT   encodes a highly conserved plasma membrane protein.";
RL   FEBS Lett. 580:2409-2413(2006).
CC   -!- FUNCTION: Plays a role in the regulation of membrane potential. Could
CC       mediate a proton leak. Regulated by the spc1-atf1 pathway and so
CC       expression is stress-induced. {ECO:0000269|PubMed:16603158}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0057 (PMP3) family. {ECO:0000305}.
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DR   EMBL; CU329671; CAC22612.2; -; Genomic_DNA.
DR   RefSeq; NP_595350.2; NM_001021258.2.
DR   AlphaFoldDB; Q9C1W4; -.
DR   BioGRID; 277644; 13.
DR   STRING; 4896.SPBC713.11c.1; -.
DR   PaxDb; Q9C1W4; -.
DR   EnsemblFungi; SPBC713.11c.1; SPBC713.11c.1:pep; SPBC713.11c.
DR   GeneID; 2541129; -.
DR   KEGG; spo:SPBC713.11c; -.
DR   PomBase; SPBC713.11c; pmp3.
DR   VEuPathDB; FungiDB:SPBC713.11c; -.
DR   eggNOG; KOG1773; Eukaryota.
DR   HOGENOM; CLU_107649_6_2_1; -.
DR   InParanoid; Q9C1W4; -.
DR   OMA; VHAIWVI; -.
DR   PRO; PR:Q9C1W4; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISO:PomBase.
DR   InterPro; IPR000612; PMP3.
DR   PANTHER; PTHR21659; PTHR21659; 1.
DR   Pfam; PF01679; Pmp3; 1.
DR   PROSITE; PS01309; UPF0057; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..57
FT                   /note="Plasma membrane proteolipid 3"
FT                   /id="PRO_0000247914"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   57 AA;  6179 MW;  1652B222A2E3B28D CRC64;
     MALTGSDIFK VIFAIILPPL GVFLERGCGA DVIINILLCC LGYVPGIIHA LYIILKY