ID   PMRA_LACLA              Reviewed;         405 AA.
AC   P58120;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Multi-drug resistance efflux pump PmrA homolog;
GN   Name=pmrA; OrderedLocusNames=LL0666; ORFNames=L60571;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Efflux pump for various substrates. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
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DR   EMBL; AE005176; AAK04764.1; -; Genomic_DNA.
DR   PIR; B86708; B86708.
DR   RefSeq; NP_266822.1; NC_002662.1.
DR   RefSeq; WP_010905496.1; NC_002662.1.
DR   AlphaFoldDB; P58120; -.
DR   SMR; P58120; -.
DR   STRING; 272623.L60571; -.
DR   PaxDb; P58120; -.
DR   EnsemblBacteria; AAK04764; AAK04764; L60571.
DR   KEGG; lla:L60571; -.
DR   PATRIC; fig|272623.7.peg.713; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_001265_57_3_9; -.
DR   OMA; IVAPLWG; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR   Pfam; PF07690; MFS_1; 2.
DR   PRINTS; PR01035; TCRTETA.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..405
FT                   /note="Multi-drug resistance efflux pump PmrA homolog"
FT                   /id="PRO_0000173375"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   405 AA;  43859 MW;  59E703164FF53DA7 CRC64;
     MNRTKTVNWK RNLFITWIGC FFVGSSFSLV MPFLPLYIQG LGVSGGNVEL YSGLAFSLPA
     LASGLVAPIW GRLADEHGRK VMMVRASIVM TLTMGGIAFA PNVWWLLGLR LLMGFFSGYI
     PNSTAMIASQ APKDKSGYAL GTLATAMVSG TLIGPSLGGL LAEWFGMANV FLIVGALLAL
     ATLLTIFFVH ENFEPIAKGE MLSSKEIINK VSNKQILFGL LVTTFIIQIT SQSIEPFVTL
     YIKTLTTSTN NLMFISGLIV SAVGLSAMLS SSFLGRLGDK YGSHRLILIG LVFTFIIYLP
     MAFVQSPLQL GILRFLLGFG TGALTPSVNS LLSKITPKEG VSRIFAYAQM CSNLGMVTGP
     LVGSAIAGYI SYRAAIVGTS LFVIVNIIWS FINFRKYLRK RSIME