ID   PMRA_LACLC              Reviewed;         119 AA.
AC   P27173;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 3.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Multi-drug resistance efflux pump PmrA homolog;
DE   Flags: Fragment;
GN   Name=pmrA;
OS   Lactococcus lactis subsp. cremoris (Streptococcus cremoris).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1359;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MG1614;
RX   PubMed=1398083; DOI=10.1016/0378-1119(92)90081-y;
RA   Koivula T., Hemilae H.;
RT   "Sequence encoding ribosomal protein L33 of Lactococcus lactis.";
RL   Gene 119:145-146(1992).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; X62621; CAA44488.1; -; Genomic_DNA.
DR   PIR; PC1133; PC1133.
DR   AlphaFoldDB; P27173; -.
DR   SMR; P27173; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           <1..119
FT                   /note="Multi-drug resistance efflux pump PmrA homolog"
FT                   /id="PRO_0000173376"
FT   TRANSMEM        <1..20
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   119 AA;  13041 MW;  66F9BEAF57016365 CRC64;
     ILIGLVFTFV IYLPMAFVQS PLQLGILRFL LGFGAGALMP SVNSLLSKIT PKEGVSRIFA
     YAQMCSNLGM VTGPLVGSAI AGYISYRAAI VGTSLFVIVN IIWSFINFRK YLRKRSIME