ID   PMRA_PECPM              Reviewed;         222 AA.
AC   Q70FH0; K4FN56;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Transcriptional regulatory protein PmrA;
GN   Name=pmrA; OrderedLocusNames=W5S_4173;
OS   Pectobacterium parmentieri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=1905730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=SCC3193;
RX   PubMed=14617142; DOI=10.1046/j.1365-2958.2003.03729.x;
RA   Hyytiaeinen H., Sjoeblom S., Palomaeki T., Tuikkala A., Palva E.T.;
RT   "The PmrA-PmrB two-component system responding to acidic pH and iron
RT   controls virulence in the plant pathogen Erwinia carotovora ssp.
RT   carotovora.";
RL   Mol. Microbiol. 50:795-807(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCC3193;
RX   PubMed=23045508; DOI=10.1128/jb.00681-12;
RA   Koskinen J.P., Laine P., Niemi O., Nykyri J., Harjunpaa H., Auvinen P.,
RA   Paulin L., Pirhonen M., Palva T., Holm L.;
RT   "Genome sequence of Pectobacterium sp. strain SCC3193.";
RL   J. Bacteriol. 194:6004-6004(2012).
CC   -!- FUNCTION: Member of the two-component regulatory system PmrB/PmrA
CC       involved in regulation of virulence. Unphosphorylated PmrA represses
CC       extracellular enzyme genes. Phosphorylation of PmrA by PmrB relieves
CC       such repression, which leads to activation of extracellular enzyme
CC       genes. Phosphorylated PmrA seems to repress expression of the pmrCAB
CC       operon. {ECO:0000269|PubMed:14617142}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by PmrB. {ECO:0000305}.
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DR   EMBL; AJ583007; CAE47079.1; -; Genomic_DNA.
DR   EMBL; CP003415; AFI92229.1; -; Genomic_DNA.
DR   RefSeq; WP_014701628.1; NC_017845.1.
DR   AlphaFoldDB; Q70FH0; -.
DR   SMR; Q70FH0; -.
DR   STRING; 1905730.W5S_4173; -.
DR   EnsemblBacteria; AFI92229; AFI92229; W5S_4173.
DR   KEGG; pec:W5S_4173; -.
DR   PATRIC; fig|1166016.3.peg.4250; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_1_6; -.
DR   OrthoDB; 1020672at2; -.
DR   Proteomes; UP000008044; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Repressor; Transcription;
KW   Transcription regulation; Two-component regulatory system; Virulence.
FT   CHAIN           1..222
FT                   /note="Transcriptional regulatory protein PmrA"
FT                   /id="PRO_0000232703"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        124..218
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   222 AA;  24868 MW;  A27A6DB780A1099B CRC64;
     MKLLIVEDDK LLQEGLLLAL SHEGYACDCA GTAKEADALI GSAHYSLVIL DLGLPDDDGL
     ALLSRWRKNN YQHPVLILTA RDKVDDRVSG LDVGADDYLA KPFALTELQA RVRALIRRNQ
     GSSNSKIQVD NITLDLNNQQ VLLDEKPVVL TPKEFAILSR LVLKAGYQVH RELLHQDIYA
     WNDDPSSNSL EVHIHNLRQK IGKDRIRTLR GFGYLLTKGE QP