PMRD_ECOLI
ID PMRD_ECOLI Reviewed; 88 AA.
AC P37590; P76475; P77155; Q5MN33; Q5MN36; Q5MN40; Q5MN44; Q5MN45; Q5MN54;
AC Q5MN59; Q5MN60; Q5MN62; Q5MN63; Q5MN64; Q5MN90; Q8KJP6;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Signal transduction protein PmrD;
DE AltName: Full=BasR post-transcriptional activator;
DE AltName: Full=Polymyxin resistance protein PmrD;
GN Name=pmrD; OrderedLocusNames=b2259, JW2254;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=8626063; DOI=10.1016/0378-1119(95)00721-0;
RA Sharma V., Hudspeth M.E.S., Meganathan R.;
RT "Menaquinone (vitamin K2) biosynthesis: localization and characterization
RT of the menE gene from Escherichia coli.";
RL Gene 168:43-48(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION BY PHOP.
RC STRAIN=ECOR 1, ECOR 10, ECOR 11, ECOR 12, ECOR 13, ECOR 14, ECOR 15,
RC ECOR 16, ECOR 17, ECOR 18, ECOR 19, ECOR 2, ECOR 20, ECOR 21, ECOR 22,
RC ECOR 23, ECOR 24, ECOR 25, ECOR 26, ECOR 27, ECOR 28, ECOR 29, ECOR 3,
RC ECOR 30, ECOR 31, ECOR 32, ECOR 33, ECOR 34, ECOR 35, ECOR 37, ECOR 38,
RC ECOR 39, ECOR 4, ECOR 40, ECOR 41, ECOR 42, ECOR 43, ECOR 44, ECOR 45,
RC ECOR 46, ECOR 47, ECOR 48, ECOR 49, ECOR 5, ECOR 51, ECOR 52, ECOR 53,
RC ECOR 54, ECOR 55, ECOR 56, ECOR 57, ECOR 58, ECOR 59, ECOR 6, ECOR 60,
RC ECOR 61, ECOR 62, ECOR 63, ECOR 64, ECOR 65, ECOR 66, ECOR 67, ECOR 68,
RC ECOR 69, ECOR 7, ECOR 70, ECOR 71, ECOR 72, ECOR 8, ECOR 9, and
RC O2:HN / ECOR 50 / P97 / UPEC;
RX PubMed=15569938; DOI=10.1073/pnas.0406038101;
RA Winfield M.D., Groisman E.A.;
RT "Phenotypic differences between Salmonella and Escherichia coli resulting
RT from the disparate regulation of homologous genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:17162-17167(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- FUNCTION: Interacts with phosphorylated BasR protein to mediate
CC transcriptional induction of BasR-activated genes to induce polymyxin
CC resistance in some natural isolates. {ECO:0000269|PubMed:15569938}.
CC -!- INDUCTION: By PhoP. {ECO:0000269|PubMed:15569938}.
CC -!- SIMILARITY: Belongs to the PmrD family. {ECO:0000305}.
CC -!- CAUTION: The PmrD protein from K12 strain (sequence shown) does not
CC interact with phosphorylated BasR protein, and thus does not seem to be
CC involved in polymyxin resistance. {ECO:0000305}.
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DR EMBL; L35031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY725349; AAV92796.1; -; Genomic_DNA.
DR EMBL; AY725350; AAV92797.1; -; Genomic_DNA.
DR EMBL; AY725351; AAV92798.1; -; Genomic_DNA.
DR EMBL; AY725352; AAV92799.1; -; Genomic_DNA.
DR EMBL; AY725353; AAV92800.1; -; Genomic_DNA.
DR EMBL; AY725354; AAV92801.1; -; Genomic_DNA.
DR EMBL; AY725355; AAV92802.1; -; Genomic_DNA.
DR EMBL; AY725356; AAV92803.1; -; Genomic_DNA.
DR EMBL; AY725357; AAV92804.1; -; Genomic_DNA.
DR EMBL; AY725358; AAV92805.1; -; Genomic_DNA.
DR EMBL; AY725359; AAV92806.1; -; Genomic_DNA.
DR EMBL; AY725360; AAV92807.1; -; Genomic_DNA.
DR EMBL; AY725361; AAV92808.1; -; Genomic_DNA.
DR EMBL; AY725362; AAV92809.1; -; Genomic_DNA.
DR EMBL; AY725363; AAV92810.1; -; Genomic_DNA.
DR EMBL; AY725364; AAV92811.1; -; Genomic_DNA.
DR EMBL; AY725365; AAV92812.1; -; Genomic_DNA.
DR EMBL; AY725366; AAV92813.1; -; Genomic_DNA.
DR EMBL; AY725367; AAV92814.1; -; Genomic_DNA.
DR EMBL; AY725368; AAV92815.1; -; Genomic_DNA.
DR EMBL; AY725369; AAV92816.1; -; Genomic_DNA.
DR EMBL; AY725370; AAV92817.1; -; Genomic_DNA.
DR EMBL; AY725371; AAV92818.1; -; Genomic_DNA.
DR EMBL; AY725372; AAV92819.1; -; Genomic_DNA.
DR EMBL; AY725373; AAV92820.1; -; Genomic_DNA.
DR EMBL; AY725374; AAV92821.1; -; Genomic_DNA.
DR EMBL; AY725375; AAV92822.1; -; Genomic_DNA.
DR EMBL; AY725376; AAV92823.1; -; Genomic_DNA.
DR EMBL; AY725377; AAV92824.1; -; Genomic_DNA.
DR EMBL; AY725378; AAV92825.1; -; Genomic_DNA.
DR EMBL; AY725379; AAV92826.1; -; Genomic_DNA.
DR EMBL; AY725380; AAV92827.1; -; Genomic_DNA.
DR EMBL; AY725381; AAV92828.1; -; Genomic_DNA.
DR EMBL; AY725382; AAV92829.1; -; Genomic_DNA.
DR EMBL; AY725383; AAV92830.1; -; Genomic_DNA.
DR EMBL; AY725384; AAV92831.1; -; Genomic_DNA.
DR EMBL; AY725385; AAV92832.1; -; Genomic_DNA.
DR EMBL; AY725386; AAV92833.1; -; Genomic_DNA.
DR EMBL; AY725387; AAV92834.1; -; Genomic_DNA.
DR EMBL; AY725388; AAV92835.1; -; Genomic_DNA.
DR EMBL; AY725389; AAV92836.1; -; Genomic_DNA.
DR EMBL; AY725390; AAV92837.1; -; Genomic_DNA.
DR EMBL; AY725391; AAV92838.1; -; Genomic_DNA.
DR EMBL; AY725392; AAV92839.1; -; Genomic_DNA.
DR EMBL; AY725393; AAV92840.1; -; Genomic_DNA.
DR EMBL; AY725394; AAV92841.1; -; Genomic_DNA.
DR EMBL; AY725395; AAV92842.1; -; Genomic_DNA.
DR EMBL; AY725396; AAV92843.1; -; Genomic_DNA.
DR EMBL; AY725397; AAV92844.1; -; Genomic_DNA.
DR EMBL; AY725398; AAV92845.1; -; Genomic_DNA.
DR EMBL; AY725399; AAV92846.1; -; Genomic_DNA.
DR EMBL; AY725400; AAV92847.1; -; Genomic_DNA.
DR EMBL; AY725401; AAV92848.1; -; Genomic_DNA.
DR EMBL; AY725402; AAV92849.1; -; Genomic_DNA.
DR EMBL; AY725403; AAV92850.1; -; Genomic_DNA.
DR EMBL; AY725404; AAV92851.1; -; Genomic_DNA.
DR EMBL; AY725405; AAV92852.1; -; Genomic_DNA.
DR EMBL; AY725406; AAV92853.1; -; Genomic_DNA.
DR EMBL; AY725407; AAV92854.1; -; Genomic_DNA.
DR EMBL; AY725408; AAV92855.1; -; Genomic_DNA.
DR EMBL; AY725409; AAV92856.1; -; Genomic_DNA.
DR EMBL; AY725410; AAV92857.1; -; Genomic_DNA.
DR EMBL; AY725411; AAV92858.1; -; Genomic_DNA.
DR EMBL; AY725412; AAV92859.1; -; Genomic_DNA.
DR EMBL; AY725413; AAV92860.1; -; Genomic_DNA.
DR EMBL; AY725414; AAV92861.1; -; Genomic_DNA.
DR EMBL; AY725415; AAV92862.1; -; Genomic_DNA.
DR EMBL; AY725416; AAV92863.1; -; Genomic_DNA.
DR EMBL; AY725417; AAV92864.1; -; Genomic_DNA.
DR EMBL; AY725418; AAV92865.1; -; Genomic_DNA.
DR EMBL; AY725419; AAV92866.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75319.2; -; Genomic_DNA.
DR EMBL; AP009048; BAA16079.2; -; Genomic_DNA.
DR PIR; A64997; A64997.
DR RefSeq; NP_416762.2; NC_000913.3.
DR RefSeq; WP_001295285.1; NZ_STEB01000008.1.
DR PDB; 2JSO; NMR; -; A=1-88.
DR PDB; 4HN7; X-ray; 2.35 A; A=1-88.
DR PDBsum; 2JSO; -.
DR PDBsum; 4HN7; -.
DR AlphaFoldDB; P37590; -.
DR BMRB; P37590; -.
DR SMR; P37590; -.
DR BioGRID; 4260491; 9.
DR BioGRID; 849519; 1.
DR IntAct; P37590; 8.
DR STRING; 511145.b2259; -.
DR jPOST; P37590; -.
DR PaxDb; P37590; -.
DR PRIDE; P37590; -.
DR EnsemblBacteria; AAC75319; AAC75319; b2259.
DR EnsemblBacteria; BAA16079; BAA16079; BAA16079.
DR GeneID; 945130; -.
DR KEGG; ecj:JW2254; -.
DR KEGG; eco:b2259; -.
DR PATRIC; fig|511145.12.peg.2352; -.
DR EchoBASE; EB2537; -.
DR eggNOG; ENOG50337I9; Bacteria.
DR HOGENOM; CLU_192298_0_0_6; -.
DR OMA; WWVKKVR; -.
DR BioCyc; EcoCyc:G7172-MON; -.
DR EvolutionaryTrace; P37590; -.
DR PRO; PR:P37590; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.650; -; 1.
DR InterPro; IPR044854; PmrD_dom.
DR InterPro; IPR038679; PmrD_sf.
DR Pfam; PF11183; PmrD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Antibiotic resistance; Reference proteome.
FT CHAIN 1..88
FT /note="Signal transduction protein PmrD"
FT /id="PRO_0000058468"
FT VARIANT 11
FT /note="N -> D (in strain: ECOR 46, ECOR 48, ECOR 49 and
FT O2:HN / ECOR 50 / P97 / UPEC)"
FT VARIANT 14
FT /note="D -> N (in strain: ECOR 53, ECOR 59 and ECOR 60)"
FT VARIANT 19
FT /note="L -> I (in strain: ECOR 23, ECOR 32, ECOR 38, ECOR
FT 39, ECOR 40, ECOR 41, ECOR 51, ECOR 52, ECOR 54, ECOR 55,
FT ECOR 56, ECOR 57, ECOR 61, ECOR 62, ECOR 63, ECOR 64, ECOR
FT 65 and ECOR 66)"
FT VARIANT 20
FT /note="M -> K (in strain: ECOR 46, ECOR 49 and O2:HN / ECOR
FT 50 / P97 / UPEC)"
FT VARIANT 27
FT /note="A -> T (in strain: ECOR 46, ECOR 48, ECOR 49 and
FT O2:HN / ECOR 50 / P97 / UPEC)"
FT VARIANT 71
FT /note="S -> C (in strain: ECOR 38, ECOR 39, ECOR 41, ECOR
FT 51, ECOR 52, ECOR 53, ECOR 54, ECOR 55, ECOR 56, ECOR 61,
FT ECOR 63, ECOR 64, ECOR 65 and ECOR 66)"
FT VARIANT 81
FT /note="C -> S (in strain: ECOR 53, ECOR 59 and ECOR 60)"
FT VARIANT 82
FT /note="K -> T (in strain: ECOR 26, ECOR 27, ECOR 29, ECOR
FT 30, ECOR 33, ECOR 44, ECOR 45, ECOR 47, ECOR 58, ECOR 67,
FT ECOR 68, ECOR 69 and ECOR 71)"
FT VARIANT 83
FT /note="V -> A (in strain: ECOR 27, ECOR 33, ECOR 38, ECOR
FT 39, ECOR 41, ECOR 44, ECOR 45, ECOR 47, ECOR 51, ECOR 52,
FT ECOR 53, ECOR 54, ECOR 55, ECOR 56, ECOR 57, ECOR 59, ECOR
FT 60, ECOR 61, ECOR 63, ECOR 64, ECOR 65, ECOR 66 and ECOR
FT 69)"
FT VARIANT 84
FT /note="A -> E (in strain: ECOR 28 and ECOR 30)"
FT CONFLICT 88
FT /note="Q -> QYVVLSWAGKSASTRS (in Ref. 1; L35031)"
FT /evidence="ECO:0000305"
FT STRAND 3..9
FT /evidence="ECO:0007829|PDB:4HN7"
FT STRAND 12..23
FT /evidence="ECO:0007829|PDB:4HN7"
FT STRAND 29..35
FT /evidence="ECO:0007829|PDB:4HN7"
FT STRAND 45..50
FT /evidence="ECO:0007829|PDB:4HN7"
FT STRAND 53..56
FT /evidence="ECO:0007829|PDB:4HN7"
FT STRAND 59..71
FT /evidence="ECO:0007829|PDB:4HN7"
FT HELIX 74..84
FT /evidence="ECO:0007829|PDB:4HN7"
SQ SEQUENCE 88 AA; 9871 MW; 0DE537EAEE5784EF CRC64;
MEWLVKKSCC NKQDNRHVLM LCDAGGAIKM IAEVKSDFAV KVGDLLSPLQ NALYCINREK
LHTVKVLSAS SYSPDEWERQ CKVAGKTQ
