ID   PMRD_SALTY              Reviewed;          85 AA.
AC   P37589; Q5MJT5; Q7BUV6;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Signal transduction protein PmrD;
DE   AltName: Full=BasR post-transcriptional activator;
DE   AltName: Full=Polymyxin resistance protein PmrD;
GN   Name=pmrD; Synonyms=pbgE2; OrderedLocusNames=STM2304;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=8206837; DOI=10.1128/jb.176.12.3589-3597.1994;
RA   Roland K.L., Esther C.R., Spitznagel J.K.;
RT   "Isolation and characterization of a gene, pmrD, from Salmonella
RT   typhimurium that confers resistance to polymyxin when expressed in multiple
RT   copies.";
RL   J. Bacteriol. 176:3589-3597(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION BY PHOP.
RC   STRAIN=S4194;
RX   PubMed=15569938; DOI=10.1073/pnas.0406038101;
RA   Winfield M.D., Groisman E.A.;
RT   "Phenotypic differences between Salmonella and Escherichia coli resulting
RT   from the disparate regulation of homologous genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:17162-17167(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-85.
RC   STRAIN=ATCC 14028s / SGSG 2262;
RX   PubMed=9570402; DOI=10.1046/j.1365-2958.1998.00757.x;
RA   Gunn J.S., Lim K.B., Krueger J., Kim K., Guo L., Hackett M., Miller S.I.;
RT   "PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A
RT   modification and polymyxin resistance.";
RL   Mol. Microbiol. 27:1171-1182(1998).
RN   [5]
RP   FUNCTION, AND INDUCTION BY PHOP.
RC   STRAIN=ATCC 14028s / SGSG 2262;
RX   PubMed=10775270; DOI=10.1093/emboj/19.8.1861;
RA   Kox L.F.F., Woesten M.M.S.M., Groisman E.A.;
RT   "A small protein that mediates the activation of a two-component system by
RT   another two-component system.";
RL   EMBO J. 19:1861-1872(2000).
RN   [6]
RP   FUNCTION, AND REPRESSION BY BASR.
RC   STRAIN=ATCC 14028s / SGSG 2262;
RX   PubMed=12676988; DOI=10.1073/pnas.0836837100;
RA   Kato A., Latifi T., Groisman E.A.;
RT   "Closing the loop: the PmrA/PmrB two-component system negatively controls
RT   expression of its posttranscriptional activator PmrD.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:4706-4711(2003).
RN   [7]
RP   FUNCTION, AND INDUCTION BY PHOP.
RC   STRAIN=ATCC 14028s / SGSG 2262;
RX   PubMed=15371344; DOI=10.1101/gad.1230804;
RA   Kato A., Groisman E.A.;
RT   "Connecting two-component regulatory systems by a protein that protects a
RT   response regulator from dephosphorylation by its cognate sensor.";
RL   Genes Dev. 18:2302-2313(2004).
CC   -!- FUNCTION: Interacts with phosphorylated BasR protein to mediate
CC       transcriptional induction of BasR-activated genes to induce polymyxin
CC       resistance. {ECO:0000269|PubMed:10775270, ECO:0000269|PubMed:12676988,
CC       ECO:0000269|PubMed:15371344}.
CC   -!- INDUCTION: By PhoP. Repressed by BasR. {ECO:0000269|PubMed:10775270,
CC       ECO:0000269|PubMed:12676988, ECO:0000269|PubMed:15371344,
CC       ECO:0000269|PubMed:15569938}.
CC   -!- SIMILARITY: Belongs to the PmrD family. {ECO:0000305}.
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DR   EMBL; U02281; AAA21322.1; -; Genomic_DNA.
DR   EMBL; AY775359; AAV92881.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL21205.1; -; Genomic_DNA.
DR   EMBL; AF036677; AAC04777.1; -; Genomic_DNA.
DR   RefSeq; NP_461246.1; NC_003197.2.
DR   RefSeq; WP_000455132.1; NC_003197.2.
DR   AlphaFoldDB; P37589; -.
DR   SMR; P37589; -.
DR   STRING; 99287.STM2304; -.
DR   PaxDb; P37589; -.
DR   EnsemblBacteria; AAL21205; AAL21205; STM2304.
DR   GeneID; 1253826; -.
DR   KEGG; stm:STM2304; -.
DR   PATRIC; fig|99287.12.peg.2439; -.
DR   HOGENOM; CLU_192298_0_0_6; -.
DR   OMA; WWVKKVR; -.
DR   BioCyc; SENT99287:STM2304-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.650; -; 1.
DR   InterPro; IPR044854; PmrD_dom.
DR   InterPro; IPR038679; PmrD_sf.
DR   Pfam; PF11183; PmrD; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic resistance; Reference proteome.
FT   CHAIN           1..85
FT                   /note="Signal transduction protein PmrD"
FT                   /id="PRO_0000058469"
SQ   SEQUENCE   85 AA;  9749 MW;  1E1922419EA50CCA CRC64;
     MEWLVKKSHY VKKRACHVLV LCDSGGSLKM IAEANSMILL SPGDILSPLQ DAQYCINREK
     HQTLKIVDAR CYSCDEWQRL TRKPS