ID   PMS1_SCHPO              Reviewed;         794 AA.
AC   P54280;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=DNA mismatch repair protein pms1;
GN   Name=pms1; ORFNames=SPAC19G12.02c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=9258673; DOI=10.1093/genetics/146.4.1275;
RA   Schar P., Baur M., Schneider C., Kohli J.;
RT   "Mismatch repair in Schizosaccharomyces pombe requires the mutL homologous
RT   gene pms1: molecular cloning and functional analysis.";
RL   Genetics 146:1275-1286(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
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DR   EMBL; X96581; CAA65400.1; -; Genomic_DNA.
DR   EMBL; CU329670; CAB10113.1; -; Genomic_DNA.
DR   PIR; T37989; T37989.
DR   RefSeq; NP_594417.1; NM_001019846.2.
DR   AlphaFoldDB; P54280; -.
DR   SMR; P54280; -.
DR   BioGRID; 279037; 18.
DR   STRING; 4896.SPAC19G12.02c.1; -.
DR   MaxQB; P54280; -.
DR   PaxDb; P54280; -.
DR   EnsemblFungi; SPAC19G12.02c.1; SPAC19G12.02c.1:pep; SPAC19G12.02c.
DR   PomBase; SPAC19G12.02c; pms1.
DR   VEuPathDB; FungiDB:SPAC19G12.02c; -.
DR   eggNOG; KOG1978; Eukaryota.
DR   HOGENOM; CLU_004131_0_2_1; -.
DR   InParanoid; P54280; -.
DR   OMA; SFNNVQY; -.
DR   PhylomeDB; P54280; -.
DR   Reactome; R-SPO-5358565; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
DR   PRO; PR:P54280; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0032389; C:MutLalpha complex; IBA:GO_Central.
DR   GO; GO:0000228; C:nuclear chromosome; ISO:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005524; F:ATP binding; ISO:PomBase.
DR   GO; GO:0016887; F:ATP hydrolysis activity; ISO:PomBase.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; NAS:PomBase.
DR   GO; GO:0043570; P:maintenance of DNA repeat elements; IMP:PomBase.
DR   GO; GO:0000710; P:meiotic mismatch repair; IMP:PomBase.
DR   GO; GO:0006298; P:mismatch repair; IGI:PomBase.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..794
FT                   /note="DNA mismatch repair protein pms1"
FT                   /id="PRO_0000178010"
FT   REGION          351..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          409..442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..383
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   794 AA;  88009 MW;  A5D46FFFA077D8DC CRC64;
     MSTVKPIDAN TVHKICSGQV ITDVASAVKE LVENSLDSGA TTIEIRFKNY GINSIEVVDN
     GSGIDAGDYE SIGKKHFTSK ITDFEDLEAL QTFGFRGEAL SSLCAVGQVI ISTATQNEAP
     KGVQLNLDHE GSLKDKLTIP FQRGTSVMVN DLFCTLPVRR KLLEKNYKRE FSKAISLLQA
     YATISTNKRF MVYHQTKNSG KLLQLSTNSN KDMKLNIMNV FGTKVSSSLI PWNDGIIEGY
     ISRPHVGSTR ASNERQMLFI NRRLVNLPKI ARVIQEVFKP YSMAQSPFFA INLRITNGTI
     DINVSPDKKS VFLSEEDSII EFIKNSLQNL CESCGHAISC SRSQSIFSYS SQIPDSSGDS
     TDQELPQSIP ATESETSDDS SFSYKRSPCK RKLVEATAQP AISTSVAEGA SLAQVSKPLP
     ERLQKDSMRR SSPLNEKVTA SSERMKKKLA LFASSTDTSM QKTIDSSFPL KQPINKPSSN
     PNNLLLNDPS PASTPVAKTI NLNEIESVHN AESVSTLSSI PRTEQTSVAN RIPSKTAALQ
     KLKFFQSRPL DGLNKFSKKI NISLSGVQKD IVRSDALLKF SNKIGVVHDI SDENQEDHLN
     LTVHKADFLR MRVVGQFNRG FIVVVHGNNL FIIDQHASDE KFNYEHLKSN LVINSQDLVL
     PKRLDLAATE ETVLIDHIDL IRRKGFGVAI DLNQRVGNRC TLLSVPTSKN VIFDTSDLLE
     IISVLSEHPQ IDPFSSRLER MLASKACRSS VMIGRALTIS EMNTIVRHLA ELSKPWNCPH
     GRPTMRHLLR LKDI