ID   AT18G_ARATH             Reviewed;         959 AA.
AC   Q8GUL1; Q56W94; Q9LR84; Q9ZVU0;
DT   03-APR-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Autophagy-related protein 18g;
DE            Short=AtATG18g;
GN   Name=ATG18G; OrderedLocusNames=At1g03380; ORFNames=F15K9.1, F21B7.1;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 631-959.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, INDUCTION, AND TISSUE SPECIFICITY.
RX   PubMed=15860012; DOI=10.1111/j.1365-313x.2005.02397.x;
RA   Xiong Y., Contento A.L., Bassham D.C.;
RT   "AtATG18a is required for the formation of autophagosomes during nutrient
RT   stress and senescence in Arabidopsis thaliana.";
RL   Plant J. 42:535-546(2005).
CC   -!- FUNCTION: The PI(3,5)P2 regulatory complex regulates both the synthesis
CC       and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
CC       Required for autophagy (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the PI(3,5)P2 regulatory complex at least
CC       composed of ATG18, SAC/FIG4, FAB1 and VAC14. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Vacuole
CC       membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC       Note=Peripheral membrane protein of pre-autophagosomal structure (PAS)
CC       and vacuole. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in leaves. {ECO:0000269|PubMed:15860012}.
CC   -!- INDUCTION: By sucrose and nitrogen starvation.
CC       {ECO:0000269|PubMed:15860012}.
CC   -!- DOMAIN: The first protein part may form a beta-propeller domain
CC       involved in specific binding to phosphatidylinositol 3,5-bisphosphate
CC       (PIP2), leading to the association of the protein to the membrane.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat PROPPIN family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC72107.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAF86508.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC002560; AAF86508.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC005278; AAC72107.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE27566.1; -; Genomic_DNA.
DR   EMBL; BT002410; AAO00770.1; -; mRNA.
DR   EMBL; AK222152; BAD95231.1; -; mRNA.
DR   PIR; F86165; F86165.
DR   PIR; T00919; T00919.
DR   RefSeq; NP_171837.7; NM_100220.8.
DR   AlphaFoldDB; Q8GUL1; -.
DR   SMR; Q8GUL1; -.
DR   STRING; 3702.AT1G03380.1; -.
DR   iPTMnet; Q8GUL1; -.
DR   PaxDb; Q8GUL1; -.
DR   PRIDE; Q8GUL1; -.
DR   ProteomicsDB; 246603; -.
DR   EnsemblPlants; AT1G03380.1; AT1G03380.1; AT1G03380.
DR   GeneID; 838702; -.
DR   Gramene; AT1G03380.1; AT1G03380.1; AT1G03380.
DR   KEGG; ath:AT1G03380; -.
DR   Araport; AT1G03380; -.
DR   TAIR; locus:2020853; AT1G03380.
DR   eggNOG; KOG2109; Eukaryota.
DR   HOGENOM; CLU_003829_1_0_1; -.
DR   InParanoid; Q8GUL1; -.
DR   OMA; PSEHFKN; -.
DR   OrthoDB; 537714at2759; -.
DR   PhylomeDB; Q8GUL1; -.
DR   PRO; PR:Q8GUL1; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q8GUL1; baseline and differential.
DR   Genevisible; Q8GUL1; AT.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042594; P:response to starvation; IEP:TAIR.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR022175; BCAS3.
DR   InterPro; IPR045142; BCAS3-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13268; PTHR13268; 1.
DR   Pfam; PF12490; BCAS3; 1.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Membrane; Protein transport; Reference proteome; Repeat;
KW   Transport; Vacuole; WD repeat.
FT   CHAIN           1..959
FT                   /note="Autophagy-related protein 18g"
FT                   /id="PRO_0000421885"
FT   REPEAT          376..416
FT                   /note="WD 1"
FT   REPEAT          438..479
FT                   /note="WD 2"
FT   REGION          802..832
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   959 AA;  104578 MW;  EF4A3FC402F36F50 CRC64;
     MMKKGKGKNS GLLPNSFKII SSCLKTVSAN ATNVASSVRS AGASVAASIS AAEDDKDQVT
     WAGFGILELG QHVTRHVLLL GYQNGFQVFD VEDASNFNEL VSKRGGPVSF LQMQPLPARS
     GDHEGFWNSH PLLLVVAGDE TNGTGLGHSF SQNGSLARDG SSDSKAGDAI NYPTTVRFYS
     LRSHSYVYVL RFRSSVCMIR CSSRVVAVGL ANQIYCVDAL TLENKFSVLT YPVPQPVRQG
     TTRVNVGYGP MAVGPRWLAY ASKSSMTMKT GRLSPQTFTS SPSLSPSSSS GGSSFMARYA
     MESSKQLANG LINLGDMGYK TLSKYCQDML PDGSTSPASP NAIWKVGGVS GSDAENAGMV
     AVKDLVSGAL VSQFKAHTSP ISALCFDPSG TLLVTASVCG NNINVFQIMP SRSHNAPGDL
     SYEWESSHVH LFKLHRGITS AIVQDICFSQ QSQWVAIISS KGTCHIFVLN SSGSDAAFQP
     CEGEEPTRLP ASSLPWWFTQ SLSSNQQSLS PPTAVALSVV SRIKYSSFGW LNTVSNATTA
     ATGKVFVPSG AVAAVFHKSV THDLQLNSRT NALEHILVYT PSGHVVQHEL LPSVCTESPE
     NGLRVQKTSH VQVQEDDLRV KVEPIQWWDV CRRSDWLETE ERLPKSITEK QYDLETVSNH
     LTSHEDACLS LDMNSHFSED KYLKSCSEKP PERSHCYLSN FEVKVTSGML PVWQNSKISF
     HVMDSPRDSS STGGEFEIEK VPAHELEIKQ KKLLPVFDHF HSTKATLEDR FSMKCYHTSA
     TGSHQVNGKI CQDIINCHSK PGSIESAESS EEGSTKQMEN LHDSDHMSNS IKSSLPLYPT
     VNGIYKEIEK NNANGWMEKP VTAKLSTLKE TRITNGFTTP PILTDSVNEQ MLSTGKPPMG
     FGFALHEEHC KAVADPKEEH LKKKLDEVTN VHHLNVNNNN TEKLQGDKMV HGMVSFVGD