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PMTA_CERSP
ID   PMTA_CERSP              Reviewed;         203 AA.
AC   Q05197;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Phosphatidylethanolamine N-methyltransferase;
DE            EC=2.1.1.17;
GN   Name=pmtA;
OS   Cereibacter sphaeroides (Rhodobacter sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=1063;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8340421; DOI=10.1016/s0021-9258(18)82350-x;
RA   Arondel V., Benning C., Somerville C.R.;
RT   "Isolation and functional expression in Escherichia coli of a gene encoding
RT   phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter
RT   sphaeroides.";
RL   J. Biol. Chem. 268:16002-16008(1993).
CC   -!- FUNCTION: This enzyme catalyzes three distinct methylation reactions
CC       for converting phosphatidylethanolamine to phosphatidylcholine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-
CC         methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine +
CC         H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:11164,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:64573, ChEBI:CHEBI:64612; EC=2.1.1.17;
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis.
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DR   EMBL; L07247; AAA26152.1; -; Genomic_DNA.
DR   PIR; A47149; A47149.
DR   AlphaFoldDB; Q05197; -.
DR   SMR; Q05197; -.
DR   UniPathway; UPA00753; -.
DR   GO; GO:0004608; F:phosphatidylethanolamine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   4: Predicted;
KW   Lipid biosynthesis; Lipid metabolism; Methyltransferase;
KW   Phospholipid biosynthesis; Phospholipid metabolism;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..203
FT                   /note="Phosphatidylethanolamine N-methyltransferase"
FT                   /id="PRO_0000058470"
SQ   SEQUENCE   203 AA;  22892 MW;  2641E07949C1F10B CRC64;
     MELDAVSRSY KRWAIYDFSF GKVSESPRRR TAAHVNARGG RVLEVGVGTG LSLPLYSHRV
     AVTGIDFSHE MLARAREKVE EMGLEPVKEL RQMDARELDF PDETFDTVVA MFLVSVVPEP
     ERVVSEMARV CRKGGEVVIV NHFARDKGPL AAVEKALARF ENTLGWHSDF AIERVTADPR
     LEVVEQTPMS PGGLFTFLRF QRR
 
 
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