PMTA_CERSP
ID PMTA_CERSP Reviewed; 203 AA.
AC Q05197;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Phosphatidylethanolamine N-methyltransferase;
DE EC=2.1.1.17;
GN Name=pmtA;
OS Cereibacter sphaeroides (Rhodobacter sphaeroides).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC Rhodobacteraceae; Cereibacter.
OX NCBI_TaxID=1063;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8340421; DOI=10.1016/s0021-9258(18)82350-x;
RA Arondel V., Benning C., Somerville C.R.;
RT "Isolation and functional expression in Escherichia coli of a gene encoding
RT phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter
RT sphaeroides.";
RL J. Biol. Chem. 268:16002-16008(1993).
CC -!- FUNCTION: This enzyme catalyzes three distinct methylation reactions
CC for converting phosphatidylethanolamine to phosphatidylcholine.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-
CC methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine +
CC H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:11164,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:64573, ChEBI:CHEBI:64612; EC=2.1.1.17;
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis.
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DR EMBL; L07247; AAA26152.1; -; Genomic_DNA.
DR PIR; A47149; A47149.
DR AlphaFoldDB; Q05197; -.
DR SMR; Q05197; -.
DR UniPathway; UPA00753; -.
DR GO; GO:0004608; F:phosphatidylethanolamine N-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF08241; Methyltransf_11; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 4: Predicted;
KW Lipid biosynthesis; Lipid metabolism; Methyltransferase;
KW Phospholipid biosynthesis; Phospholipid metabolism;
KW S-adenosyl-L-methionine; Transferase.
FT CHAIN 1..203
FT /note="Phosphatidylethanolamine N-methyltransferase"
FT /id="PRO_0000058470"
SQ SEQUENCE 203 AA; 22892 MW; 2641E07949C1F10B CRC64;
MELDAVSRSY KRWAIYDFSF GKVSESPRRR TAAHVNARGG RVLEVGVGTG LSLPLYSHRV
AVTGIDFSHE MLARAREKVE EMGLEPVKEL RQMDARELDF PDETFDTVVA MFLVSVVPEP
ERVVSEMARV CRKGGEVVIV NHFARDKGPL AAVEKALARF ENTLGWHSDF AIERVTADPR
LEVVEQTPMS PGGLFTFLRF QRR