ID   PMTG_ARATH              Reviewed;         631 AA.
AC   O80844;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Probable methyltransferase PMT16;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=At2g45750; ORFNames=F4I18.27;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY.
RX   PubMed=17461780; DOI=10.1111/j.1365-313x.2007.03123.x;
RA   Krupkova E., Immerzeel P., Pauly M., Schmulling T.;
RT   "The TUMOROUS SHOOT DEVELOPMENT2 gene of Arabidopsis encoding a putative
RT   methyltransferase is required for cell adhesion and co-ordinated plant
RT   development.";
RL   Plant J. 50:735-750(2007).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Single-pass type II membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AC004665; AAC28550.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC10597.1; -; Genomic_DNA.
DR   PIR; T02472; T02472.
DR   RefSeq; NP_182099.1; NM_130138.3.
DR   AlphaFoldDB; O80844; -.
DR   iPTMnet; O80844; -.
DR   PaxDb; O80844; -.
DR   PRIDE; O80844; -.
DR   ProteomicsDB; 226283; -.
DR   EnsemblPlants; AT2G45750.1; AT2G45750.1; AT2G45750.
DR   GeneID; 819183; -.
DR   Gramene; AT2G45750.1; AT2G45750.1; AT2G45750.
DR   KEGG; ath:AT2G45750; -.
DR   Araport; AT2G45750; -.
DR   TAIR; locus:2050679; AT2G45750.
DR   eggNOG; ENOG502QQT2; Eukaryota.
DR   HOGENOM; CLU_010485_2_2_1; -.
DR   InParanoid; O80844; -.
DR   OMA; DARIADH; -.
DR   OrthoDB; 275436at2759; -.
DR   PhylomeDB; O80844; -.
DR   PRO; PR:O80844; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; O80844; baseline and differential.
DR   Genevisible; O80844; AT.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR004159; Put_SAM_MeTrfase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR10108; PTHR10108; 1.
DR   Pfam; PF03141; Methyltransf_29; 1.
DR   SUPFAM; SSF53335; SSF53335; 2.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Methyltransferase;
KW   Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..631
FT                   /note="Probable methyltransferase PMT16"
FT                   /id="PRO_0000393256"
FT   TOPO_DOM        1..14
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        15..35
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        36..631
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        61
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        230
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        626
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   631 AA;  72102 MW;  5CEB993E4AF84C29 CRC64;
     MNLFTRISSR TKKANLYYVT LVALLCIASY LLGIWQNTAV NPRAAFDDSD GTPCEGFTRP
     NSTKDLDFDA HHNIQDPPPV TETAVSFPSC AAALSEHTPC EDAKRSLKFS RERLEYRQRH
     CPEREEILKC RIPAPYGYKT PFRWPASRDV AWFANVPHTE LTVEKKNQNW VRYENDRFWF
     PGGGTMFPRG ADAYIDDIGR LIDLSDGSIR TAIDTGCGVA SFGAYLLSRN ITTMSFAPRD
     THEAQVQFAL ERGVPAMIGI MATIRLPYPS RAFDLAHCSR CLIPWGQNDG AYLMEVDRVL
     RPGGYWILSG PPINWQKRWK GWERTMDDLN AEQTQIEQVA RSLCWKKVVQ RDDLAIWQKP
     FNHIDCKKTR EVLKNPEFCR HDQDPDMAWY TKMDSCLTPL PEVDDAEDLK TVAGGKVEKW
     PARLNAIPPR VNKGALEEIT PEAFLENTKL WKQRVSYYKK LDYQLGETGR YRNLVDMNAY
     LGGFAAALAD DPVWVMNVVP VEAKLNTLGV IYERGLIGTY QNWCEAMSTY PRTYDFIHAD
     SVFTLYQGQC EPEEILLEMD RILRPGGGVI IRDDVDVLIK VKELTKGLEW EGRIADHEKG
     PHEREKIYYA VKQYWTVPAP DEDKNNTSAL S